Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sonia Gandhi"'
Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation
Autor:
Plamena R. Angelova, Mikhail S. Shchepinov, Andrey Y. Abramov, David Klenerman, Sergiy Sylantyev, Karamjit Singh Dolt, Sonia Gandhi, Paul Gissen, Evgeny Pavlov, Margarida Rodrigues, Mathew H. Horrocks, A. V. Berezhnov, Suman De, Ratsuda Yapom, Craig D. Hughes, Tilo Kunath, Daniel Little, Minee L. Choi, Michael J. Devine
Publikováno v:
Angelova, P R, Choi, M L, Berezhnov, A V, Horrocks, M, Hughes, C D, De, S, Rodrigues, M, Yapom, R, Little, D, Dolt, K, Kunath, T, Devine, M J, Gissen, P, Shchepinov, M S, Sylantyev, S, Pavlov, E V, Klenerman, D, Abramov, A Y & Gandhi, S 2020, ' Alpha synuclein aggregation drives ferroptosis : An interplay of iron, calcium and lipid peroxidation ', Cell Death and Differentiation . https://doi.org/10.1038/s41418-020-0542-z
Protein aggregation and abnormal lipid homeostasis are both implicated in neurodegeneration through unknown mechanisms. Here we demonstrate that aggregate-membrane interaction is critical to induce a form of cell death called ferroptosis. Importantly
Autor:
Charles Swanton, James I. MacRae, Nnennaya Kanu, Steve Hindmarsh, Karen Ambrose, Andrew Levett, Judith Heaney, Maria Greco, Christopher Earl, Stuart Kirk, Rachel Instrell, Simon Caidan, Peter Cherepanov, Vicky Dearing, Wei-Ting Lu, Laura E. McCoy, George Kassiotis, Mary Wu, Amelia Edwards, Andrew Rowan, Michael Howell, Jessica Olsen, Venizelos Papayannopoulos, Amar Pabari, Caetano Reis e Sousa, Wai Keong Wong, Nicola O’Reilly, Marc Pollitt, Jerome Nicod, Philip A. Walker, Ming Jiang, Marg Crawford, Ganka Bineva-Todd, Alessandra Gaiba, Melanie Turner, Jacki Goldman, James M. A. Turner, Chloe Roustan, Sonia Gandhi, Catherine Moore, Nigel Peat, Rachel Rosenthal, John N. S. Matthews, Amy Strange, Chris Ekin, Marcel Levi, Richard D. Byrne, Laura Churchward, Steve Gamblin, Graham Clark, Jim Aitken, Deb Jackson, Mark Johnson, Svend Kjaer, Joshua Wright, Annachiara Rosa, Andreas Wack, Ok-Ryul Song, Laura Cubitt, Mariam Jamal-Hanjani, David Moore, Leigh Jones, Debbie Hughes, Paul Grant, Sophie Ward, Efthymios Fidanis, Namita Patel, Eleni Nastouli, Dhruva Biswas, Gee Yen Shin, Daniel M Snell, Mike Hubank, Lisa Levett, Moria Spyer, Peter J. Ratcliffe, Luke Nightingale, Sam Barrell, Rupert Beale, Robert L. Goldstone, Catherine F Houlihan
The emergence of the novel coronavirus SARS-CoV-2 has led to a pandemic infecting more than two million people worldwide in less than four months, posing a major threat to healthcare systems. This is compounded by the shortage of available tests caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6706544deaba13268147d688fa1ec9d0
https://doi.org/10.1101/2020.04.19.20071373
https://doi.org/10.1101/2020.04.19.20071373
Autor:
Bictash M, AB Singleton, Helene Plun-Favreau, Nicholas W. Wood, David Zhang, Monaghan Ae, Paul Whiting, Claudia Manzoni, Alan M. Pittman, Welsh Nj, Ryten M, Guelfi S, Mark R. Cookson, John Hardy, Benjamin O’Callaghan, Annuario E, Danyah Trabzuni, Patrick A. Lewis, Alexander J. Whitworth, Marc P.M. Soutar, Cornelis Blauwendraat, Sonia Gandhi, Demis A. Kia, Daniela Melandri, Pan Ks, Henry Houlden, D’Sa K
Parkinson’s disease (PD) is a common incurable neurodegenerative disease. The identification of genetic variants via genome-wide association studies (GWAS) has considerably advanced our understanding of the PD genetic risk. Understanding the functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a586a41c3816d5f348ac92485873c54
Autor:
Juan A. Varela, Margarida Rodrigues, Suman De, Patrick Flagmeier, Sonia Gandhi, Christopher M. Dobson, David Klenerman, Steven F. Lee
Publikováno v:
Angewandte Chemie International Edition
This study is supported by the Michael J. Fox Foundation (10200); The Royal Society with a University Research Fellowship (UF120277) (S.F.L.); a Marie‐Curie Individual Fellowship (S.D.); the Boehringer Ingelheim Fonds (P.F.), the Studienstiftung de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::313567ec46b5f24a6e40d60f3a33c3f2
Publikováno v:
Biophysical Journal. 110(3)
Presence of α-synuclein aggregates in the brain is one of the major pathological hallmarks of Parkinson's disease (PD) and a point mutation in the gene encoding a-synuclein has been reported in familial PD cases. Previously, we have shown that for w
Autor:
Helene Plun-Favreau, Nicholas W. Wood, Alexander J. Whitworth, Robert J. Harvey, Sonia Gandhi, Samantha H. Y. Loh, Andrey Y. Abramov, L. Miguel Martins, Emma Deas, Howard Desmond, Alan E. Renton, Svend Kjaer
Publikováno v:
Human Molecular Genetics
Mutations in PTEN-induced kinase 1 (PINK1) cause early onset autosomal recessive Parkinson's disease (PD). PINK1 is a 63 kDa protein kinase, which exerts a neuroprotective function and is known to localize to mitochondria. Upon entry into the organel
Autor:
Nicholas W. Wood, Helene Plun-Favreau, Sonia Gandhi, Alison Wood-Kaczmar, Julian Downward, Sarah J. Tabrizi, Michael R. Duchen, David S. Latchman, Kristina Klupsch, Zhi Yao, Andrey Y. Abramov, Emma Deas
Publikováno v:
Molecular Cell
Summary Mutations in PINK1 cause autosomal recessive Parkinson's disease. PINK1 is a mitochondrial kinase of unknown function. We investigated calcium homeostasis and mitochondrial function in PINK1-deficient mammalian neurons. We demonstrate physiol
Autor:
Andrey Y. Abramov, Nicholas W. Wood, Marthe H.R. Ludtmann, Plamena R. Stroh, Sonia Gandhi, David Klenerman
Publikováno v:
Biophysical Journal. 106(2)
Alpha-synuclein is a protein expressed abundantly in the brain that has been proposed to have multiple physiological functions as signal transduction, vesicular trafficking, synaptic behaviour, regulation of oxidative stress and mitochondrial functio
Autor:
Plamena R. Angelova, Marthe H. R. Ludtmann, Mathew H. Horrocks, Alexander Negoda, Nunilo Cremades, David Klenerman, Christopher M. Dobson, Nicholas W. Wood, Evgeny V. Pavlov, Sonia Gandhi, Andrey Y. Abramov
Publikováno v:
Development. 143:e1.1-e1.1
Autor:
Marthe H.R. Ludtmann, Andrey Y. Abramov, Plamena R. Angelova, Vladimir L. Buchman, Natalia Ninkina, Sonia Gandhi
Publikováno v:
Biophysical Journal. 110:471a
Despite a wealth of publications about the role of alpha-synuclein in Parkinson's disease, very little has been reported about this protein's physiological function in health. This current study established an important function for native α-synucle