Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Leonardo Guasti"'
Autor:
Tansit Saengkaew, Gerard Ruiz-Babot, Alessia David, Alessandra Mancini, Katia Mariniello, Claudia P. Cabrera, Michael R. Barnes, Leo Dunkel, Leonardo Guasti, Sasha R. Howard
Publikováno v:
NPJ Genomic Medicine
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-11 (2021)
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-11 (2021)
Developmental abnormalities of the gonadotropin-releasing hormone (GnRH) neuronal network result in a range of conditions from idiopathic hypogonadotropic hypogonadism to self-limited delayed puberty. We aimed to discover important underlying regulat
Autor:
Leonardo Guasti, Karoliina Wehkalampi, Ojeda, Howard, Alessia David, Claudia P. Cabrera, Alejandro Lomniczi, Leo Dunkel, Michael R. Barnes, Sabine Heger, Alessandra Mancini
Publikováno v:
Human Molecular Genetics
The initiation of puberty is orchestrated by an augmentation of gonadotropin-releasing hormone (GnRH) secretion from a few thousand hypothalamic neurons. Recent findings have indicated that the neuroendocrine control of puberty may be regulated by a
Publikováno v:
Frontiers in Endocrinology, Vol 6 (2015)
Frontiers in Endocrinology
Frontiers in Endocrinology
Adrenal disease, whether primary, caused by defects in the hypothalamic–pituitary–adrenal (HPA) axis, or secondary, caused by defects outside the HPA axis, usually results in adrenal insufficiency, which requires lifelong daily replacement of cor
Publikováno v:
Molecular and Cellular Endocrinology
Highlights ► The adrenal glands from fgfr2IIIb knock-out mice are hypoplastic. ► Steroidogenic enzymes are reduced in fgfr2IIIb knock-out mice. ► Dlk1, rather than Shh, signalling is affected in the adrenal cortex of fgfr2IIIb knock-out mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af3c8e3be293657c2e8ddec34b670f9d
https://openaccess.sgul.ac.uk/id/eprint/102367/1/1-s2.0-S0303720713000373-main.pdf
https://openaccess.sgul.ac.uk/id/eprint/102367/1/1-s2.0-S0303720713000373-main.pdf
Publikováno v:
Journal of Molecular Endocrinology
The melanocortin-2-receptor (MC2R)/MC2R accessory protein (MRAP) complex is critical to the production of glucocorticoids from the adrenal cortex. Inactivating mutations in either MC2R or MRAP result in the clinical condition familial glucocorticoid
Autor:
Khalil Eldeeb, Stephen P.H. Alexander, David A. Kendall, Leonardo Guasti, Victoria Chapman, Maulik D. Jhaveri, Gregory J. Michael, Maurice R. Elphick, Denise Richardson, David A. Barrett
Publikováno v:
Molecular Pain, Vol 5, Iss 1, p 35 (2009)
Molecular Pain
Molecular Pain
Activation of spinal microglia contributes to aberrant pain responses associated with neuropathic pain states. Endocannabinoids (ECs) are present in the spinal cord, and inhibit nociceptive processing; levels of ECs may be altered by microglia which
Autor:
Leonardo Guasti, Yuliya V. Korolkova, Rita Restano-Cassulini, Enzo Wanke, Annarosa Arcangeli, Michel Lazdunski, Sylvie Diochot, Eugene V. Grishin, Lourival D. Possani, Georgina B. Gurrola
Publikováno v:
Molecular Pharmacology
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2006, 69, pp.1673-1683
Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2006, 69, pp.1673-1683
The ether-a-go-go-related gene (erg) K+ channels are known to be crucial for life in Caenorhabditis elegans (mating), Drosophila melanogaster (seizure), and humans (LQT syndrome). The erg genes known to date (erg1, erg2, and erg3) are highly expresse