Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Dipanjan Chowdhury"'
Autor:
Connor Clairmont, Alan D. D'Andrea, Guillaume Adelmant, Dipanjan Chowdhury, Jarrod A. Marto, Karthikeyan Ponnienselvan, Lucas D. Galli, Prabha Sarangi, Lisa A. Moreau, Isabelle Csete
Publikováno v:
Proc Natl Acad Sci U S A
Nat Cell Biol
Nat Cell Biol
DNA double-strand breaks (DSBs) are repaired through homology-directed repair (HDR) or non-homologous end joining (NHEJ). BRCA1/2-deficient cancer cells cannot perform HDR, conferring sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPi). How
Autor:
Madeline Polak, Joyce F. Liu, Andrea E. Wahner Hendrickson, Elise C. Kohn, Ursula A. Matulonis, Geoffrey I. Shapiro, Panagiotis A. Konstantinopoulos, Nabihah Tayob, Bose Kochupurakkal, Alan D. D'Andrea, Elizabeth K. Lee, Su Chun Cheng, Doga Gulhan, David L. Kolin, Anniina Färkkilä, Dipanjan Chowdhury, Elizabeth H. Stover, Jennifer Curtis, Alexandre André B.A. da Costa
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
In a trial of patients with high grade serous ovarian cancer (HGSOC), addition of the ATR inhibitor berzosertib to gemcitabine improved progression free survival (PFS) compared to gemcitabine alone but biomarkers predictive of treatment are lacking.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fc5f0b6a3806ed3027197865ef213b
http://hdl.handle.net/10138/336193
http://hdl.handle.net/10138/336193
Autor:
Mason Tarpley, Suravi Pramanik, Hannah L. Harris, David Klinkebiel, Dipanjan Chowdhury, Aniruddha Sarkar, Paul L. Sorgen, Gaelle Spagnol, Shrabasti Roychoudhury, Kishor K. Bhakat, Vimla Band
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance G-quadruplex (G4) structures in functionally important genomic regions regulate multiple biological processes in cells. This study demonstrates a genome-wide correlation between the occurrence of endogenous oxidative base damage, activat
Autor:
Gaofeng Cui, Veronica Rendo, Huy V. Nguyen, Nishita Parnandi, Dipanjan Chowdhury, Rameen Beroukhim, Pascal Drané, Georges Mer, Matthias Altmeyer, Maria Victoria Botuyan, Michaela Remisova
Publikováno v:
Mol Cell
53BP1 influences genome stability via two independent mechanisms: (1) regulating DNA double-strand break (DSB) repair and (2) enhancing p53 activity. We discovered a protein, Tudor-interacting repair regulator (TIRR), that associates with the 53BP1 T
Autor:
Urszula Smyczynska, Dipanjan Chowdhury, Szymon Grabia, Wojciech Fendler, Konrad Pagacz, Przemysław Kucharski
Publikováno v:
BMC Genomics
BMC Genomics, Vol 21, Iss 1, Pp 1-15 (2020)
BMC Genomics, Vol 21, Iss 1, Pp 1-15 (2020)
BackgroundThe consensus on how to choose a reference gene for serum or plasma miRNA expression qPCR studies has not been reached and none of the potential candidates have yet been convincingly validated. We proposed a new in silico approach of findin
Autor:
Pol Margalef, Anthony J. Cesare, Valerie Borel, Panagiotis Kotsantis, Dipanjan Chowdhury, Ambrosius P. Snijders, Grzegorz Sarek, Helen R. Flynn, David Van Ly, Phil Ruis, Simon J. Boulton, Xiaofeng Zheng
Publikováno v:
Nature
The protection of telomere ends by the shelterin complex prevents DNA damage signalling and promiscuous repair at chromosome ends. Evidence suggests that the 3′ single-stranded telomere end can assemble into a lasso-like t-loop configuration1,2, wh
Autor:
Peter Deraska, Kalindi Parmar, Geoffrey I. Shapiro, Huy V. Nguyen, Alan D. D'Andrea, Dipanjan Chowdhury, Xiaofeng Zheng, Connor E. Dunn, Timothy Branigan, Feng Li, David Kozono, James A. DeCaprio
Publikováno v:
Molecular Cell. 80:410-422.e6
While effective anti-cancer drugs targeting the CHK1 kinase are advancing in the clinic, drug resistance is rapidly emerging. Here, we demonstrate that CRISPR-mediated knockout of the little-known gene FAM122A/PABIR1 confers cellular resistance to CH
Autor:
Luigi Nezi, David Pellman, Karen Crasta, Regina Dagher, Elena Ivanova, Yunfeng Pan, Neil J. Ganem, Dipanjan Chowdhury, Alexei Protopopov, Alexandra B. Lantermann
Publikováno v:
Nature
The involvement of whole-chromosome aneuploidy in tumorigenesis is the subject of debate, in large part because of the lack of insight into underlying mechanisms. Here we identify a mechanism by which errors in mitotic chromosome segregation generate
Autor:
Ranjan Sen, Dipanjan Chowdhury
Publikováno v:
Immunity. 18:229-241
Production of immunoglobulin heavy chain (IgH) protein feeds back to terminate further V H gene recombination, a phenomenon also referred to as allelic exclusion. Here we provide evidence to support the proposition that allelic exclusion is the conse
Autor:
Panagiotis A. Konstantinopoulos, Yunfeng Pan, Dipanjan Chowdhury, Alan D. D'Andrea, Young Eun Choi, Subhajyoti De, Eunmi Park
Publikováno v:
eLife
eLife, Vol 3 (2014)
eLife, Vol 3 (2014)
Homologous recombination (HR)-mediated repair of DNA double-strand break (DSB)s is restricted to the post-replicative phases of the cell cycle. Initiation of HR in the G1 phase blocks non-homologous end joining (NHEJ) impairing DSB repair. Completion