Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dajiang. J. Liu"'
Autor:
Scott I. Vrieze, Gretchen R.B. Saunders, Seon-Kyeong Jang, Yu Jiang, Mengzhen Liu, Dajiang J. Liu
Publikováno v:
Psychol Med
BackgroundSubstance use occurs at a high rate in persons with a psychiatric disorder. Genetically informative studies have the potential to elucidate the etiology of these phenomena. Recent developments in genome-wide association studies (GWAS) allow
Autor:
Shuang Jiang, Jiwoong Kim, Dajiang J. Liu, Xiaowei Zhan, Yiqing Wang, Yang Xie, Qiwei Li, Andrew Y. Koh, Guanghua Xiao
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 11, Iss 4 (2021)
G3: Genes, Genomes, Genetics, Vol 11, Iss 4 (2021)
In microbiome research, metagenomic sequencing generates enormous amounts of data. These data are typically classified into taxa for taxonomy analysis, or into genes for functional analysis. However, a joint analysis where the reads are classified in
Autor:
Marju Orho-Melander, Humberto García-Ortiz, Xueling Sim, Amp-T D-Genes, Cheol Joo Park, Gina M. Peloso, Jason Flannick, Brian Tomlinson, Hyun Min Kang, Emilio J. Cordova, Stephen S. Rich, Richard A. Gibbs, Angélica Martínez-Hernández, Lorena Orozco, Harsha Doddapaneni, Lisa R. Yanek, Jiwon Lee, Namrata Gupta, Valeriya Lyssenko, Sohee Han, James B. Meigs, Bong-Jo Kim, Bruce M. Psaty, Leslie S. Emery, Kerrin S. Small, Pradeep Natarajan, May E. Montasser, Christian Gieger, Sharon L.R. Kardia, Sarah C. Nelson, Craig L. Hanis, Heikki A. Koistinen, María Elena González-Villalpando, Edmund Chan, Michael Y. Tsai, Benjamin Glaser, Thomas Meitinger, Matthew J. Bown, Mariaelisa Graff, John Danesh, Sekar Kathiresan, Tiinamaija Tuomi, Ramachandran S. Vasan, Gil Atzmon, Alyna T. Khan, Diego Ardissino, Yii-Der Ida Chen, David Zhang, Rob M. van Dam, Wendy S. Post, Barry I. Freedman, D. C. Rao, Michael Preuss, Donna M. Lehman, L. Adrienne Cupples, Colin N. A. Palmer, Claudia H. T. Tam, Hortensia Moreno-Macías, Markku Laakso, Peter Dornbos, Teresa Tusié-Luna, Stella Aslibekyan, Marguerite R. Irvin, Daniel J. Rader, Jee-Young Moon, Eimear E. Kenny, Lisa W. Martin, Jennifer A. Brody, Amit Khera, Erwin P. Bottinger, Sarah E. Graham, Myriam Fornage, Ruth McPherson, Nancy L. Heard-Costa, Michael Boehnke, Clicerio Gonzalez, Ryan W. Kim, Yi-Cheng Chang, Peter M. Nilsson, Yik Ying Teo, Robert Sladek, Cristen J. Willer, Fei Fei Wang, Donna K. Arnett, Mark Chaffin, Karine A. Viaud Martinez, Alanna C. Morrison, Leslie A. Lange, Ravindranath Duggirala, Donna M. Muzny, Kent D. Taylor, Niels Grarup, Soren Germer, Patricia A. Peyser, Brian E. Cade, Lewis C. Becker, Steven A. Lubitz, Nicholette D. Palmer, Susan K. Dutcher, Ronald C.W. Ma, Xuenan Mi, Xiuqing Guo, Hugh Watkins, Eric Boerwinkle, Qibin Qi, Johanna Kuusisto, Christie M. Ballantyne, Tanika N. Kelly, Rajiv Chowdhury, Elvia Mendoza-Caamal, Wing-Yee So, Tien Yin Wong, Torben Hansen, Cecilia Contreras-Cubas, Jeong-Sun Seo, Mi Yeong Hwang, Daekwan Seo, Dajiang J. Liu, Cristina Revilla-Monsalve, Paul S. de Vries, Daniel R. Witte, Yi-Jen Hung, Olle Melander, Karen L. Mohlke, Lucinda Antonacci-Fulton, Francisco Barajas-Olmos, Soo Heon Kwak, Daniel E. Weeks, Claudia Schurmann, Ginger A. Metcalf, Young-Jin Kim, Adrienne M. Stilp, Lori L. Bonnycastle, John Blangero, Ralph A. DeFronzo, Donald W. Bowden, Rasika A. Mathias, Oluf Pedersen, Rozenn N. Lemaitre, Stephen T. McGarvey, Heribert Schunkert, Jaakko Tuomilehto, Farook Thameem, Valentin Fuster, Joshua C. Bis, George Hindy, Allan Linneberg, James G. Wilson, Kyong Soo Park, Sergio A. Islas-Andrade, Ching-Yu Cheng, Won Jung Choi, Minxian X. Wang, Xuzhi Wang, Adolfo Correa, Jai G. Broome, Gail P. Jarvik, Alexander P. Reiner, E. Shyong Tai, Juyoung Lee, Mark I. McCarthy, Nilesh J. Samani, Susan Redline, Carlos A. Aguilar-Salinas, Jerome I. Rotter, Ma. Eugenia Garay-Sevilla, Jiang He, Patrick T. Ellinor, Joseph Park, Joanne E. Curran, Nir Barzilai, Federico Centeno-Cruz, Seonwook Lee, Lawrence F. Bielak, Jianjun Liu, Charles Kooperberg, Juan M. Peralta, Jose C. Florez, Leif Groop, Noël P. Burtt, Margaret Sunitha Selvaraj, Jeffrey R. O'Connell, Ruth J. F. Loos
Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele frequency170,000 individuals f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08cffcbe73ed87d1953f10593c831399
https://doi.org/10.1101/2020.12.22.423783
https://doi.org/10.1101/2020.12.22.423783
Autor:
Yu Jiang, Sai Chen, Xingyan Wang, Mengzhen Liu, William G. Iacono, John K. Hewitt, John E. Hokanson, Kenneth Krauter, Markku Laakso, Kevin W. Li, Sharon M. Lutz, Matthew McGue, Anita Pandit, Gregory J.M. Zajac, Michael Boehnke, Goncalo R. Abecasis, Scott I. Vrieze, Bibo Jiang, Xiaowei Zhan, Dajiang J. Liu
Publikováno v:
Genes, Vol 11, Iss 586, p 586 (2020)
Genes
Volume 11
Issue 5
Genes
Volume 11
Issue 5
There is great interest in understanding the impact of rare variants in human diseases using large sequence datasets. In deep sequence datasets of >
10,000 samples, ~10% of the variant sites are observed to be multi-allelic. Many of the multi-
10,000 samples, ~10% of the variant sites are observed to be multi-allelic. Many of the multi-
Autor:
Yaqun Wang, Xiang Zhan, Songshan Yang, Jiawei Wen, Dajiang J. Liu, Rongling Wu, Runze Li, Scott Eckert
Publikováno v:
Bioinformatics
Motivation Large scale genome-wide association studies (GWAS) have resulted in the identification of a wide range of genetic variants related to a host of complex traits and disorders. Despite their success, the individual single-nucleotide polymorph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f8c104125723ae8538e3be2842b2df
https://europepmc.org/articles/PMC7320616/
https://europepmc.org/articles/PMC7320616/
Publikováno v:
Bioinformatics
Summary Here, we present a highly efficient R-package seqminer2 for querying and retrieving sequence variants from biobank scale datasets of millions of individuals and hundreds of millions of genetic variants. Seqminer2 implements a novel variant-ba
Autor:
Jonggul Kim, Guan-Yu Xiao, Shuang Jiang, Yang Xie, Qiwei Li, Dajiang J. Liu, Andrew Y. Koh, Xiaoming Zhan
BackgroundIn microbiome research, metagenomic sequencing generates enormous amounts of data. These data are typically classified into taxa for taxonomy analysis, or into genes for functional analysis. However, a joint analysis where the reads are cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e8c734c8b00c2cdc35c1383db22b79
https://doi.org/10.21203/rs.2.22868/v1
https://doi.org/10.21203/rs.2.22868/v1
Autor:
Ching-Ti Liu, Michael Boehnke, George Dedoussis, Sophie V. Eastwood, Ruth J. F. Loos, Keng-Hung Lin, Denis Rybin, Fredrik Karpe, Martina Müller-Nurasyid, Michael A. Province, Alison D. Murray, Bo Isomaa, Eirini Marouli, Konstantin Strauch, Michael Preuss, Paul M. Ridker, Jette Bork-Jensen, Albert V. Smith, Hugoline G. de Haan, Wayne Huey-Herng Sheu, Barbara Thorand, Wolfgang Rathmann, Lawrence F. Bielak, Peter Kovacs, Marit E. Jørgensen, Jennifer Wessel, Danish Saleheen, Jung-Jin Lee, James B. Meigs, Veikko Salomaa, Alena Stančáková, Tibor V. Varga, Hidetoshi Kitajima, Inês Barroso, Kent D. Taylor, Claudia Langenberg, Yoon Shin Cho, Joanna M. M. Howson, Andrew T. Hattersley, Marie-France Hivert, Markku Laakso, Kai-Uwe Eckardt, Bram P. Prins, Matthias B. Schulze, Andrew D. Morris, Susanne Jäger, Francis S. Collins, Kristi Läll, Xu Lin, Anette Varbo, Benjamin Lehne, Girish N. Nadkarni, Jonathan Marchini, Daniel I. Chasman, Michael Stumvoll, Mark O. Goodarzi, Cécile Lecoeur, Philippe M. Frossard, Noël P. Burtt, Frank Kee, Jasmina Kravic, Alain G. Bertoni, Ivan Brandslund, Najaf Amin, Lenore J. Launer, Oluf Pedersen, Johanna Kuusisto, Line Rode, Eleftheria Zeggini, Yingchang Lu, Markus Perola, Helen R. Warren, André G. Uitterlinden, Hanieh Yaghootkar, Torben Hansen, Harald Grallert, Annemari Käräjämäki, Abbas Dehghan, Gina M. Peloso, Yii-Der Ida Chen, Man Li, Shaofeng Huo, Lars Lind, Karen L. Mohlke, Adrienne Tin, Yang Hai, Renée de Mutsert, Gudmar Thorleifsson, Marie Moitry, Sune F. Nielsen, Sara M. Willems, Matthias Wuttke, Weihua Zhang, Young-Jin Kim, Giovanni Malerba, Richard A. Jensen, Loic Yengo, Mickaël Canouil, Kurt Lohman, Robert A. Scott, Tamara B. Harris, Ruifang Li-Gao, Florian Kronenberg, Anke Tönjes, Bok-Ghee Han, Krista Fischer, Thomas Meitinger, James S. Pankow, Jaakko Tuomilehto, Adam S. Butterworth, Jerome I. Rotter, Olov Rolandsson, Xiuqing Guo, Cramer Christensen, Marie Loh, Elizabeth Selvin, Bong-Jo Kim, Audrey Y. Chu, Reedik Mägi, Josée Dupuis, Anna Köttgen, Jean Ferrières, Jin Li, Robert Sladek, Leslie A. Lange, Niels Grarup, Roberta McKean-Cowdin, Cristen J. Willer, Jose C. Florez, Valgerdur Steinthorsdottir, Karina Meidtner, Annette Peters, Børge G. Nordestgaard, Rajiv Chowdhury, Ioanna Ntalla, Emma Ahlqvist, Leif Groop, Nicholas J. Wareham, Kerrin S. Small, Tiinamaija Tuomi, Cecilia M. Lindgren, Katharine R. Owen, Giovanni Gambaro, Cornelia M. van Duijn, Dennis O. Mook-Kanamori, Kenneth Rice, Erik Ingelsson, Colin N. A. Palmer, Sharon L.R. Kardia, Neil R. Robertson, Dajiang J. Liu, Sebastian Schönherr, Daniel Taliun, Sekar Kathiresan, James G. Wilson, Ping An, Patricia A. Peyser, Matthias Blüher, Frits R. Rosendaal, John C. Chambers, Caroline Hayward, Shoaib Afzal, Fernando Rivadineira, Marielisa Graff, Pranav Yajnik, Vasiliki Mamakou, Juan Fernandez Tajes, Stefan Gustafsson, Heather M. Highland, Vilmantas Giedraitis, Andrew R. Wood, Saima Afaq, Jaspal S. Kooner, Megan L. Grove, Jennifer A. Brody, Andrew P. Morris, James P. Cook, Praveen Surendran, Jennifer Kriebel, Heikki A. Koistinen, Kari Stefansson, Anders Rosengren, Rainer Rauramaa, Satu Männistö, Oscar H. Franco, Yongmei Liu, N. William Rayner, Blair H. Smith, Erwin P. Bottinger, Ayse Demirkan, Allan Linneberg, Jonathan Marten, Huaixing Li, Sung Soo Kim, Sophie Hackinger, Cristina Bombieri, Lia B. Bang, Jun Liu, Asif Rasheed, Tim D. Spector, Paul W. Franks, Mark I. McCarthy, Heiner Boeing, Anne E. Justice, Vilmundur Gudnason, Sohee Han, Unnur Thorsteinsdottir, Panos Deloukas, Naveed Sattar, Eric Boerwinkle, Martin Ingelsson, John Danesh, Vassily Trubetskoy, Marco M Ferrario, Marju Orho-Melander, Wei Gan, Philippe Froguel, Symen Ligthart, Susan R. Heckbert, Jie Yao, Anne Tybjærg-Hansen, Robin Young, Daniel R. Witte, Anubha Mahajan, Peter Almgren, Timothy M. Frayling, Tanya M. Teslovich, Matt Neville, Philippe Amouyel, Wei Zhao, Andres Metspalu, Yao Hu, Olle Melander, Kari Kuulasmaa, Jason Flannick, Torben Jørgensen, Stephen S. Rich, Nicole Soranzo, Bruce M. Psaty, Rohit Varma
Publikováno v:
Grarup, N, Jørgensen, M E, Witte, D R, Hansen, T, Pedersen, O, ExomeBP Consortium, MAGIC Consortium & GIANT Consortium 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
Mahajan, A, Wessel, J, Willems, S M, Zhao, W, Robertson, N R, Chu, A Y, Gan, W, Kitajima, H, Taliun, D, Rayner, N W, Guo, X, Lu, Y, Li, M, Jensen, R A, Hu, Y, Huo, S, Lohman, K K, Zhang, W, Cook, J P, Prins, B P, Flannick, J, Grarup, N, Trubetskoy, V V, Kravic, J, Kim, Y J, Rybin, D V, Yaghootkar, H, Müller-Nurasyid, M, Meidtner, K, Li-Gao, R, Varga, T V, Marten, J, Li, J, Smith, A V, An, P, Ligthart, S, Gustafsson, S, Malerba, G, Demirkan, A, Tajes, J F, Steinthorsdottir, V, Wuttke, M, Lecoeur, C, Preuss, M, Bielak, L F, Graff, M, Highland, H M, Morris, A & Hayward, C & Morris, A P 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
Mahajan, A, Wessel, J, Willems, S M, Zhao, W, Robertson, N R, Chu, A Y, Gan, W, Kitajima, H, Taliun, D, Rayner, N W, Guo, X, Lu, Y, Li, M, Jensen, R A, Hu, Y, Huo, S, Lohman, K K, Zhang, W, Cook, J P, Prins, B P, Flannick, J, Grarup, N, Trubetskoy, V V, Kravic, J, Kim, Y J, Rybin, D V, Yaghootkar, H, Müller-Nurasyid, M, Meidtner, K, Li-Gao, R, Varga, T V, Marten, J, Li, J, Smith, A V, An, P, Ligthart, S, Gustafsson, S, Malerba, G, Demirkan, A, Tajes, J F, Steinthorsdottir, V, Wuttke, M, Lecoeur, C, Preuss, M, Bielak, L F, Graff, M, Highland, H M, Justice, A E, Liu, D J, Marouli, E, Peloso, G M, Warren, H R, ExomeBP Consortium, MAGIC Consortium, GIANT Consortium, Afaq, S, Afzal, S, Ahlqvist, E, Almgren, P, Amin, N, Bang, L B, Bertoni, A G, Bombieri, C, Bork-Jensen, J, Brandslund, I, Brody, J A, Burtt, N P, Canouil, M, Chen, Y-D I, Cho, Y S, Christensen, C, Eastwood, S V, Eckardt, K-U, Fischer, K, Gambaro, G, Giedraitis, V, Grove, M L, de Haan, H G, Hackinger, S, Hai, Y, Han, S, Tybjærg-Hansen, A, Hivert, M-F, Isomaa, B, Jäger, S, Jørgensen, M E, Jørgensen, T, Käräjämäki, A, Kim, B-J, Kim, S S, Koistinen, H A, Kovacs, P, Kriebel, J, Kronenberg, F, Läll, K, Lange, L A, Lee, J-J, Lehne, B, Li, H, Lin, K-H, Linneberg, A, Liu, C-T, Liu, J, Loh, M, Mägi, R, Mamakou, V, McKean-Cowdin, R, Nadkarni, G, Neville, M, Nielsen, S F, Ntalla, I, Peyser, P A, Rathmann, W, Rice, K, Rich, S S, Rode, L, Rolandsson, O, Schönherr, S, Selvin, E, Small, K S, Stančáková, A, Surendran, P, Taylor, K D, Teslovich, T M, Thorand, B, Thorleifsson, G, Tin, A, Tönjes, A, Varbo, A, Witte, D R, Wood, A R, Yajnik, P, Yao, J, Yengo, L, Young, R, Amouyel, P, Boeing, H, Boerwinkle, E, Bottinger, E P, Chowdhury, R, Collins, F S, Dedoussis, G, Dehghan, A, Deloukas, P, Ferrario, M M, Ferrieres, J, Florez, J C, Frossard, P, Gudnason, V, Harris, T B, Heckbert, S R, Howson, J M M, Ingelsson, M, Kathiresan, S, Kee, F, Kuusisto, J, Langenberg, C, Launer, L J, Lindgren, C M, Männistö, S, Meitinger, T, Melander, O, Mohlke, K L, Moitry, M, Morris, A P, Murray, A D, de Mutsert, R, Orho-Melander, M, Owen, K R, Perola, M, Peters, A, Province, M A, Rasheed, A, Ridker, P M, Rivadineira, F, Rosendaal, F R, Rosengren, A H, Salomaa, V, Sheu, W H-H, Sladek, R, Willer, C J, Blüher, M, Butterworth, A S, Chambers, J C, Chasman, D I, Danesh, J, van Duijn, C M, Dupuis, J, Franco, O H, Franks, P W, Froguel, P, Grallert, H, Groop, L, Kardia, S L R, Karpe, F, Kooner, J S, Köttgen, A, Kuulasmaa, K, Laakso, M, Lin, X, Lind, L, Liu, Y, Loos, R J F, Marchini, J, Metspalu, A, Mook-Kanamori, D O, Nordestgaard, B G, Palmer, C N A, Pankow, J S, Pedersen, O, Psaty, B M, Rauramaa, R, Sattar, N, Schulze, M B, Soranzo, N, Spector, T D, Stefansson, K, Stumvoll, M, Thorsteinsdottir, U, Tuomi, T, Tuomilehto, J, Wareham, N J, Wilson, J G, Zeggini, E, Scott, R A, Barroso, I, Frayling, T M, Goodarzi, M O, Meigs, J B, Boehnke, M, Saleheen, D, Morris, A P, Rotter, J I & McCarthy, M I 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
ExomeBP Consortium 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
Nature Genetics
Nat. Genet. 50, 559-571 (2018)
NATURE GENETICS
ExomeBP Consortium, MAGIC Consortium, GIANT Consortium, Witte, D R & Hansen, T 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
Nature genetics
Nature Genetics, 50(4), 559-+. Nature Publishing Group
Nature Genetics, 50(4), 559
Mahajan, A, Wessel, J, Willems, S M, Zhao, W, Robertson, N R, Chu, A Y, Gan, W, Kitajima, H, Taliun, D, Rayner, N W, Guo, X, Lu, Y, Li, M, Jensen, R A, Hu, Y, Huo, S, Lohman, K K, Zhang, W, Cook, J P, Prins, B P, Flannick, J, Grarup, N, Trubetskoy, V V, Kravic, J, Kim, Y J, Rybin, D V, Yaghootkar, H, Müller-Nurasyid, M, Meidtner, K, Li-Gao, R, Varga, T V, Marten, J, Li, J, Smith, A V, An, P, Ligthart, S, Gustafsson, S, Malerba, G, Demirkan, A, Tajes, J F, Steinthorsdottir, V, Wuttke, M, Lecoeur, C, Preuss, M, Bielak, L F, Graff, M, Highland, H M, Morris, A & Hayward, C & Morris, A P 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
Mahajan, A, Wessel, J, Willems, S M, Zhao, W, Robertson, N R, Chu, A Y, Gan, W, Kitajima, H, Taliun, D, Rayner, N W, Guo, X, Lu, Y, Li, M, Jensen, R A, Hu, Y, Huo, S, Lohman, K K, Zhang, W, Cook, J P, Prins, B P, Flannick, J, Grarup, N, Trubetskoy, V V, Kravic, J, Kim, Y J, Rybin, D V, Yaghootkar, H, Müller-Nurasyid, M, Meidtner, K, Li-Gao, R, Varga, T V, Marten, J, Li, J, Smith, A V, An, P, Ligthart, S, Gustafsson, S, Malerba, G, Demirkan, A, Tajes, J F, Steinthorsdottir, V, Wuttke, M, Lecoeur, C, Preuss, M, Bielak, L F, Graff, M, Highland, H M, Justice, A E, Liu, D J, Marouli, E, Peloso, G M, Warren, H R, ExomeBP Consortium, MAGIC Consortium, GIANT Consortium, Afaq, S, Afzal, S, Ahlqvist, E, Almgren, P, Amin, N, Bang, L B, Bertoni, A G, Bombieri, C, Bork-Jensen, J, Brandslund, I, Brody, J A, Burtt, N P, Canouil, M, Chen, Y-D I, Cho, Y S, Christensen, C, Eastwood, S V, Eckardt, K-U, Fischer, K, Gambaro, G, Giedraitis, V, Grove, M L, de Haan, H G, Hackinger, S, Hai, Y, Han, S, Tybjærg-Hansen, A, Hivert, M-F, Isomaa, B, Jäger, S, Jørgensen, M E, Jørgensen, T, Käräjämäki, A, Kim, B-J, Kim, S S, Koistinen, H A, Kovacs, P, Kriebel, J, Kronenberg, F, Läll, K, Lange, L A, Lee, J-J, Lehne, B, Li, H, Lin, K-H, Linneberg, A, Liu, C-T, Liu, J, Loh, M, Mägi, R, Mamakou, V, McKean-Cowdin, R, Nadkarni, G, Neville, M, Nielsen, S F, Ntalla, I, Peyser, P A, Rathmann, W, Rice, K, Rich, S S, Rode, L, Rolandsson, O, Schönherr, S, Selvin, E, Small, K S, Stančáková, A, Surendran, P, Taylor, K D, Teslovich, T M, Thorand, B, Thorleifsson, G, Tin, A, Tönjes, A, Varbo, A, Witte, D R, Wood, A R, Yajnik, P, Yao, J, Yengo, L, Young, R, Amouyel, P, Boeing, H, Boerwinkle, E, Bottinger, E P, Chowdhury, R, Collins, F S, Dedoussis, G, Dehghan, A, Deloukas, P, Ferrario, M M, Ferrieres, J, Florez, J C, Frossard, P, Gudnason, V, Harris, T B, Heckbert, S R, Howson, J M M, Ingelsson, M, Kathiresan, S, Kee, F, Kuusisto, J, Langenberg, C, Launer, L J, Lindgren, C M, Männistö, S, Meitinger, T, Melander, O, Mohlke, K L, Moitry, M, Morris, A P, Murray, A D, de Mutsert, R, Orho-Melander, M, Owen, K R, Perola, M, Peters, A, Province, M A, Rasheed, A, Ridker, P M, Rivadineira, F, Rosendaal, F R, Rosengren, A H, Salomaa, V, Sheu, W H-H, Sladek, R, Willer, C J, Blüher, M, Butterworth, A S, Chambers, J C, Chasman, D I, Danesh, J, van Duijn, C M, Dupuis, J, Franco, O H, Franks, P W, Froguel, P, Grallert, H, Groop, L, Kardia, S L R, Karpe, F, Kooner, J S, Köttgen, A, Kuulasmaa, K, Laakso, M, Lin, X, Lind, L, Liu, Y, Loos, R J F, Marchini, J, Metspalu, A, Mook-Kanamori, D O, Nordestgaard, B G, Palmer, C N A, Pankow, J S, Pedersen, O, Psaty, B M, Rauramaa, R, Sattar, N, Schulze, M B, Soranzo, N, Spector, T D, Stefansson, K, Stumvoll, M, Thorsteinsdottir, U, Tuomi, T, Tuomilehto, J, Wareham, N J, Wilson, J G, Zeggini, E, Scott, R A, Barroso, I, Frayling, T M, Goodarzi, M O, Meigs, J B, Boehnke, M, Saleheen, D, Morris, A P, Rotter, J I & McCarthy, M I 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
ExomeBP Consortium 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
Nature Genetics
Nat. Genet. 50, 559-571 (2018)
NATURE GENETICS
ExomeBP Consortium, MAGIC Consortium, GIANT Consortium, Witte, D R & Hansen, T 2018, ' Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes ', Nature Genetics, vol. 50, no. 4, pp. 559-571 . https://doi.org/10.1038/s41588-018-0084-1
Nature genetics
Nature Genetics, 50(4), 559-+. Nature Publishing Group
Nature Genetics, 50(4), 559
Identification of coding variant associations for complex diseases offers a direct route to biological insight, but is dependent on appropriate inference concerning the causal impact of those variants on disease risk. We aggregated coding variant dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ef38d341d4079e9196cb70cb035e2c
https://pure.au.dk/portal/da/publications/refining-the-accuracy-of-validated-target-identification-through-coding-variant-finemapping-in-type-2-diabetes(c1213cf4-47ab-49e6-b8e6-e3a85d879ef4).html
https://pure.au.dk/portal/da/publications/refining-the-accuracy-of-validated-target-identification-through-coding-variant-finemapping-in-type-2-diabetes(c1213cf4-47ab-49e6-b8e6-e3a85d879ef4).html
Autor:
Gonçalo R. Abecasis, Matt McGue, Michael Boehnke, Bibo Jiang, Yu Jiang, Anita Pandit, Markku Laakso, Mengzhen Liu, Gregory J.M. Zajac, Dajiang J. Liu, Sai Chen, Sharon M. Lutz, Kevin Li, John E. Hokanson, Daniel McGuire, Scott I. Vrieze, John K. Hewitt, William G. Iacono, Xiaowei Zhan, Kenneth Krauter
Meta-analysis of genetic association studies increases sample size and the power for mapping complex traits. Existing methods are mostly developed for datasets without missing values. In practice, genotype imputation is not always effective, e.g. whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a83ce0051b16ab63bf51af7c4535809
https://doi.org/10.1101/222695
https://doi.org/10.1101/222695
Autor:
Jean-Claude Tardif, Andries R. van der Leij, Hilary A. Tindle, Nicholas G. Martin, Rebecca Rohde, Charles Kooperberg, Francesco Cucca, Jian Gong, Jenny Chang-Claude, Tatiana Foroud, Dajiang J. Liu, Sarah Bertelsen, Gonçalo R. Abecasis, Christopher A. Haiman, Massimo Mangino, Daniel O. Stram, Jaakko Kaprio, Guillaume Lettre, Leah Wetherill, Daniel R. Barnes, Yaming Shao, David M. Brazel, Heather M. Stringham, Tinca J. C. Polderman, Wei Zhao, Andrew C. Heath, Matt McGue, Christiaan de Leeuw, Alison Goate, Danielle Posthuma, Xiaowei Zhan, Sean P. David, Laura J. Bierut, Yi Ling Chou, Pamela A. F. Madden, Manav Kapoor, Jessica D. Faul, Anu Loukola, John P. Rice, H. Steven Scholte, Arpana Agrawal, Jeff Haessler, William G. Iacono, Giorgio Pistis, Michael Boehnke, Tim D. Spector, Anke R. Hammerschlag, Charles B. Eaton, Sharon L.R. Kardia, David Schlessinger, David R. Weir, Dongbing Lai, Scott I. Vrieze, Markku Laakso, Chu Chen, Turcot, Nhung Le, Alex P. Reiner, Beenish Qaiser, Chris Hsu, A. Mesut Erzurumluoglu, Kari E. North, Carl A. Melbourne, Jennifer A. Smith
BackgroundSmoking and alcohol use behaviors in humans have been associated with common genetic variants within multiple genomic loci. Investigation of rare variation within these loci holds promise for identifying causal variants impacting biological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6747e50674a767c37219f979da37626