Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Youyou Hu"'
Autor:
Claudio Zanna, Cinta Hierro, A. John Iafrate, Josep Tabernero, Rebecca S. Heist, Nobuya Ishii, Funda Meric-Bernstam, Valerie Nicolas-Metral, James M. Cleary, Anna Pokorska-Bocci, Keith T. Flaherty, Martin H. Voss, Yulia Kirpicheva, Anne Vaslin Chessex, Leena Gandhi, José Baselga, Youyou Hu, Filip Janku, Darrell R. Borger
Publikováno v:
Clinical Cancer Research. 25:2699-2707
Purpose: To investigate tolerability, efficacy, and pharmacokinetics/pharmacodynamics of Debio 1347, a selective FGFR inhibitor. Patients and Methods: This was a first-in-human, multicenter, open-label study in patients with advanced solid tumors har
Autor:
David M. Hyman, Anne Vaslin, Funda Meric-Bernstam, Tsu Yi Chao, Matthew C.H. Ng, James M. Cleary, Nobuya Ishii, Keith T. Flaherty, Anna Pokorska-Bocci, Claudio Zanna, Lipika Goyal, Rebecca S. Heist, Youyou Hu, Do-Youn Oh, Yung-Jue Bang, Gopa Iyer, Martin H. Voss, Yulia Kirpicheva
BACKGROUND: Cholangiocarcinoma (CCA), an aggressive epithelial neoplasm of biliary tract, presents limited treatment options and poor overall survival. Aberrant fibroblast growth factor receptor (FGFR) signaling has been implicated in CCA carcinogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237326b2909e287b71144fd296991277
https://europepmc.org/articles/PMC6421195/
https://europepmc.org/articles/PMC6421195/
Autor:
Funda Meric-Bernstam, Valerie Nicolas-Metral, Lipika Goyal, Youyou Hu, David M. Hyman, Keith T. Flaherty, Petros Grivas, Yulia Kirpicheva, Anne Vaslin, Anna Pokorska-Bocci, Josep Tabernero, Claudio Zanna
Publikováno v:
Journal of Clinical Oncology. 37:TPS3157-TPS3157
TPS3157 Background: Dysregulation of fibroblast growth factor receptor (FGFR) signaling by FGFR fusions is implicated in many cancers. Debio 1347 is a selective oral inhibitor of FGFR 1-3 tyrosine kinases. It exhibited high antitumor activity in in v