Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Xin-Hua Feng"'
Autor:
Li Shen, Jian Zou, Qingzhe Wu, Shengduo Liu, Shiying Wu, Jun Qin, Songying Ouyang, Fansen Meng, Xin-Hua Feng, Fei Zhang, Xinran Li, Ruyuan Zhou, Jun Huang, Pinglong Xu, Zongping Xia, Hai Song, Qian Zhang
Publikováno v:
Nature Cell Biology. 21:1027-1040
Sensing cytosolic DNA through the cGAS–STING pathway constitutes a widespread innate immune mechanism to monitor cellular damage and microbial invasion. Evading this surveillance is crucial in tumorigenesis, but the process remains largely unexplor
Autor:
Tao Huang, Jin Jin, Xin-tao Mao, Rong-bei Liu, Yu Zhang, Jiang-yan Zhong, Xin-Hua Feng, Zhengjun Gao, Ling-jie Huang, Jian-shuai Yu, Ke-qi Fan, Yuan Zhao, Qian Cao, Fei Wang, Peng Xiao, Yiyuan Li
Publikováno v:
Journal of Clinical Investigation. 129:2856-2871
Calcineurin acts as a calcium-activated phosphatase that dephosphorylates various substrates, including members of the nuclear factor of activated T cells (NFAT) family, to trigger their nuclear translocation and transcriptional activity. However, th
Autor:
Tingbo Liang, Yulong Wang, Youli Zu, Ting Liu, Zhe Chen, Yongxian Xu, Bin Zhao, Junfang Ji, Jun Qin, Yi Li, Xia Lin, Xin-Hua Feng, Stephen P. Malkoski, Qianting Zhang, Yi Yu, Hongxing Wu, Mu Xiao, Lan Qin, Shuchen Gu, Hao Li, Hongbin Ji, Fenfang Chen, Chen Ding, Pinglong Xu, Li Shen, Yezhang Zhu
Publikováno v:
Nature Cell Biology. 21:179-189
Loss of TGF-β tumour suppressive response is a hallmark of human cancers. As a central player in TGF-β signal transduction, SMAD4 (also known as DPC4) is frequently mutated or deleted in gastrointestinal and pancreatic cancer. However, such genetic
Autor:
Xin-Hua Feng, Xinran Li
Publikováno v:
Biochemical pharmacology. 180
The Transforming Growth Factor-β (TGF-β) signaling pathway plays a versatile role in diverse physiological and disease conditions. Outcomes of TGF-β signaling are divergent, sometimes even opposite, on cellular functions and disease progression th
Autor:
Vivekananda Shetty, Sung Yun Jung, Brett H. Graham, William E. Mitch, Yanlin Wang, Xin-Hua Feng, Tanqi Lou, Hui Peng, Jun Qin, Qianqian Wang, Zhaoyong Hu, Feng Li
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications
Nature Communications
Kidney injury initiates metabolic reprogramming in tubule cells that contributes to the development of chronic kidney disease (CKD). Exercise has been associated with beneficial effects in patients with CKD. Here we show that the induction of a myoki
Autor:
Jian Zhang, Wei Chen, Tao Wei, Qi Zhang, Xueli Bai, Qi Yang, Tingbo Liang, Xin-Hua Feng, Hao Liu, Jiaqi Yang, Liang Wen, Yue Zhou, Bryan Wei Chen
Publikováno v:
Cancer Letters. 382:195-202
G protein-coupled estrogen receptor (GPER) is a novel estrogen-binding receptor involved in many pathological conditions, including cancer. In this study, we investigated the effect of GPER on hepatocellular carcinoma (HCC). Our data show GPER knocko
Autor:
Qi Chen, Lin Wang, Tao Wei, Chengxuan Yu, Jie Feng, Ce Ma, Jiaqi Yang, Junqing Wu, Guoji Guo, Junli Wang, Jianing Wang, Xiaozhen Zhang, Yali Zhao, Xing Huang, Qi Zhang, Tingbo Liang, Yu Lou, Qihan Fu, Hongbin Ge, Jiangchao Wu, Yanyu Xiao, Mao Ye, Xueli Bai, Xin-Hua Feng, Yiwen Chen
Publikováno v:
Gut. 68(11)
ObjectiveHepatocellular carcinoma (HCC) is heterogeneous, especially in multifocal tumours, which decreases the efficacy of clinical treatments. Understanding tumour heterogeneity is critical when developing novel treatment strategies. However, a com
Autor:
Ting Liu, Jun Huang, Ye Zhang, Jinquan Liu, Meiling Zhao, Zhou He, Xin-Hua Feng, Xia Lin, Han You
Publikováno v:
Oncogene
Smad proteins are central mediators in the canonical transforming growth factor-β (TGF-β) signaling pathway in mammalian cells. We report here that bromodomain-containing protein 7 (BRD7) functions as a novel transcription coactivator for Smads in
Publikováno v:
Journal of Biological Chemistry. 291:11518-11528
Twist1 is a basic helix-loop-helix transcription factor that strongly promotes epithelial-to-mesenchymal transition, migration, invasion, and metastasis of cancer cells. The MAPK-phosphorylated Twist1 on its serine 68 (Ser(P)(68)-Twist1) has a signif
Autor:
Ling Jin, Yulin Sun, Qi-Min Zhan, Hongjun Gao, Karolina Peplowska, Zhao-You Tang, Xin Zheng, Xiyang Wei, Brenda Y. Hernandez, Linda L. Wong, Junfang Ji, Xiaohang Zhao, Niya Liu, Xin-Hua Feng, Yuanzhuo Gu
Publikováno v:
Cancer research. 79(5)
Various cancer stem cell (CSC) biomarkers have been identified for hepatocellular carcinoma (HCC), but little is known about the implications of heterogeneity and shared molecular networks within the CSC population. Through miRNA profile analysis in