Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Tomi P. Mäkelä"'
Autor:
Emmy W. Verschuren, Pekka Paivinen, Sushil Tripathi, Ashwini S. Nagaraj, Eva Domenech-Moreno, Tomi P. Mäkelä, Kari Vaahtomeri, Iris P. L. Wong, Sarang S. Talwelkar, Marc Foretz, Benoit Viollet, Yan Yan, Yajing Gao
Publikováno v:
Clinical Cancer Research
Clinical Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Purpose: Mutations in STK11 (LKB1) occur in 17% of lung adenocarcinoma (LUAD) and drive a suppressive (cold) tumor immune microenvironment (TIME) and resistance to immunotherapy. The mechanisms underpinning the establishment and maintenance of a cold
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0196986 (2018)
PLoS ONE, Vol 13, Iss 5, p e0196986 (2018)
The controlled formation and stabilization of E-cadherin-based adhesions is vital for epithelial integrity. This requires co-operation between the E-cadherin-based adhesions and the associated actin cytoskeleton. In cancer, this co-operation often fa
Publikováno v:
EMBO reports. 14:741-747
Loss of primary cilia is frequently observed in tumour cells, including glioblastoma cells, and proposed to benefit tumour growth, but a causal link has not been established. Here, we show that CCRK (cell cycle-related kinase) and its substrate ICK (
Autor:
Yan Yan, Tea Vallenius, Tomi P. Mäkelä, Iris P. L. Wong, Jorma J. Palvimo, Kari Vaahtomeri, Saara Ollila
Publikováno v:
Nature Communications
Article
AMP-activated protein kinase (AMPK) inhibits several anabolic pathways such as fatty acid and protein synthesis, and identification of AMPK substrate specificity would be useful to understand its role in particular cellular processes and
AMP-activated protein kinase (AMPK) inhibits several anabolic pathways such as fatty acid and protein synthesis, and identification of AMPK substrate specificity would be useful to understand its role in particular cellular processes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66609806e6560b215a785df5efc6527b
http://hdl.handle.net/10138/165272
http://hdl.handle.net/10138/165272
Autor:
Tomi P. Mäkelä, Mira Heinonen, Alexandra Thiel, Marie-Christine Rio, Ari Ristimäki, Annabrita Hemmes, Kirsi Narko, Caj Haglund, Catherine Tomasetto
Publikováno v:
International Journal of Cancer. 131:1032-1041
Cyclooxygenase-2 (Cox-2) expression is a marker of reduced survival in gastric cancer patients, and inhibition of Cox-2 suppresses gastrointestinal carcinogenesis in experimental animal models. To investigate the role of Cox-2 in gastric carcinogenes
Publikováno v:
Molecular and Cellular Biology. 29:315-323
Mammalian Cdk7, cyclin H, and Mat1 form the kinase submodule of transcription factor IIH (TFIIH) and have been considered ubiquitously expressed elements of the transcriptional machinery. Here we found that Mat1 and Cdk7 levels are undetectable in ad
Autor:
Niklas Ekman, Marianne Tiainen, Tea Vallenius, Pekka Katajisto, Tomi P. Mäkelä, Kari Vaahtomeri, Anou Londesborough
Publikováno v:
Development. 135:2331-2338
Inactivation of the tumor suppressor kinase Lkb1 in mice leads to vascular defects and midgestational lethality at embryonic day 9-11 (E9-E11). Here, we have used conditional targeting to investigate the defects underlying the Lkb1(-/-) phenotype. En
Publikováno v:
Molecular and Cellular Biology. 27:6177-6182
The Cdk8 kinase and associated proteins form a nonessential transcriptional repressor module of the Mediator in the budding yeast Saccharomyces cerevisiae. Genetic analyses of this module have demonstrated functions ranging from environmental respons
Autor:
Tea Vallenius, Lina Udd, Kari Vaahtomeri, Tomi P. Mäkelä, Marianne Tiainen, Pekka Katajisto, Niklas Ekman
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1775:63-75
Inactivating germline mutations in the LKB1 gene underlie Peutz-Jeghers syndrome characterized by hamartomatous polyps and an elevated risk for cancer. Recent studies suggest the involvement of LKB1 also in more common human disorders including diabe
Autor:
Lauri A. Aaltonen, Virpi Launonen, Keijo Luukko, Nina Korsisaari, Tomi P. Mäkelä, Ari Ristimäki, Antti Ylikorkala, Mark Henkemeyer, Derrick J. Rossi, Reijo Salovaara
Publikováno v:
Proceedings of the National Academy of Sciences. 99:12327-12332
Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe gastrointestinal polyposis. In all cases, the polyps ar