Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sunkyu Kim"'
Autor:
Jaesang Kim, Byungwook Lee, Ye Eun Jang, Daehan Kim, Insu Jang, Jaewoo Kang, Subin Cho, Keonwoo Kim, Sanghyuk Lee, Sangok Kim, Sunkyu Kim, Jaewon Kim, Jimin Hwang
Publikováno v:
Nucleic Acids Research
Fusion genes represent an important class of biomarkers and therapeutic targets in cancer. ChimerDB is a comprehensive database of fusion genes encompassing analysis of deep sequencing data (ChimerSeq) and text mining of publications (ChimerPub) with
Autor:
Malte Gersch, Thomas M. Charlton, Michael J. Clague, Linxiang Lan, Hannah C. Scott, Sylvie Urbé, George Vere, Min Wu, Sunkyu Kim, Stephanos Ioannidis, Claire Heride, Jeffrey D Kearns, Jonathan O'Connell, David Komander, Adan Pinto-Fernandez, E. Josue Ruiz, Emma Nye, Axel Behrens, Benedikt M. Kessler, Andrew P. Turnbull, Marie Katz, Natalia Moncaut, Andreas Damianou, Wojciech W. Krajewski, Neil P. Jones, Christopher J. Dinsmore, Ian Rosewell, Tim Hammonds, David Joseph Guerin, Eva M. Riising, Crystal McKinnon, Clive Da Costa
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient’s 5-year survival rate is less than 5%. The ubiquitin-specific protease 28 (USP
Autor:
Giordano Caponigro, Emmanuelle di Tomaso, William R. Sellers, Iain Mulford, Sunkyu Kim, Alice Loo, Scott Delach, Michael G. Acker, Maria Pinzon-Ortiz, Barbara Schacher Engstler, Ralph Tiedt, Christopher Thomas Brain, Thomas Horn, Rajiv Chopra, Kristy Haas, Steven Kovats, Alexander Cao
Publikováno v:
Oncotarget
Inhibition of cyclin-dependent kinases 4 and 6 (CDK4/6) is associated with robust antitumor activity. Ribociclib (LEE011) is an orally bioavailable CDK4/6 inhibitor that is approved for the treatment of hormone receptor-positive, human epidermal grow
Publikováno v:
Bioinformatics
Motivation Recent advances in deep learning have offered solutions to many biomedical tasks. However, there remains a challenge in applying deep learning to survival analysis using human cancer transcriptome data. As the number of genes, the input va
Autor:
Yuji Mishina, Jianling Wang, Choi-Lai Tiong-Yip, He Guo, Noel Marie-France Thomsen, Jill Nunez, Franco Lombardo, Clayton Springer, Jason Baird, L. Alex Gaither, John D. Norris, Sunkyu Kim, Brant Firestone, Stefan Peukert, Kaitlin J. Macchi, Donald P. McDonnell, Tinya Abrams, Chunrong Wang, Bing Yu, Lawrence G. Hamann, Yingchuan Sun, Burks Heather Elizabeth, Christina A. Kirby, George Scott Tria
Publikováno v:
Journal of Medicinal Chemistry. 61:2837-2864
In breast cancer, estrogen receptor alpha (ERα) positive cancer accounts for approximately 74% of all diagnoses, and in these settings, it is a primary driver of cell proliferation. Treatment of ERα positive breast cancer has long relied on endocri
Autor:
Yael P. Mosse, You Qun He, Hannah T. Ryles, Renata Sano, Lori S. Hart, Nicole R. Infarinato, Theodore D. Hansel, Kateryna Krytska, Giordano Caponigro, Timothy R. Smith, Kathryn B. Grandinetti, Frederick J. King, Edward K. Ainscow, Sunkyu Kim, Shiva Krupa, Tove Tuntland, Andrew C. Wood, Jennifer L. Harris, Nanxin Li
Publikováno v:
Clinical Cancer Research. 23:2856-2868
Purpose: Anaplastic lymphoma kinase (ALK) is the most frequently mutated oncogene in the pediatric cancer neuroblastoma. We performed an in vitro screen for synergistic drug combinations that target neuroblastomas with mutations in ALK to determine w
Autor:
Shiva Krupa, Lucy Chen, Lori S. Hart, John M. Maris, Scott Delach, Yimei Li, Giordano Caponigro, Vandana Batra, Sudha Parasuraman, Sunkyu Kim, Markus Boehm, Mike R. Russell, Kristina A. Cole, Pichai Raman, Daniel Martinez, Andrew Wood, JulieAnn Rader, Malte Peters, Matthew Tsang, Maria Gagliardi
Publikováno v:
Clinical Cancer Research. 23:1785-1796
Purpose: Neuroblastoma is treated with aggressive multimodal therapy, yet more than 50% of patients experience relapse. We recently showed that relapsed neuroblastomas frequently harbor mutations leading to hyperactivated ERK signaling and sensitivit
Autor:
Donghyeon Park, Hwisang Jeon, Yonghwa Choi, Miyoung Ko, Minji Jeon, Jinhyuk Lee, Sunkyu Kim, Aik Choon Tan, Jaewoo Kang
Publikováno v:
Bioinformatics (Oxford, England). 35(24)
Motivation Traditional drug discovery approaches identify a target for a disease and find a compound that binds to the target. In this approach, structures of compounds are considered as the most important features because it is assumed that similar
Publikováno v:
BMC Medical Genomics
BMC Medical Genomics, Vol 11, Iss S2, Pp 57-69 (2018)
BMC Medical Genomics, Vol 11, Iss S2, Pp 57-69 (2018)
Background Embedding techniques for converting high-dimensional sparse data into low-dimensional distributed representations have been gaining popularity in various fields of research. In deep learning models, embedding is commonly used and proven to
Autor:
Sungjoon Park, Sunkyu Kim, Kyubum Lee, Byounggun Kim, Sunwon Lee, Wonho Shin, Aik Choon Tan, Yonghwa Choi, Jaewoo Kang, Seongsoon Kim
Publikováno v:
BMC Bioinformatics
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-13 (2018)
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-13 (2018)
Background Molecular biomarkers that can predict drug efficacy in cancer patients are crucial components for the advancement of precision medicine. However, identifying these molecular biomarkers remains a laborious and challenging task. Next-generat