Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Ronald Herbst"'
Autor:
Kristen Arnold, Chris Morehouse, Eleanor Clancy-Thompson, Katharina Deschler, Susannah Hewitt, Russell Karp, Ameya Apte, Chris Bagnall, Faith Musenge, Darren Potz, David A. Leinster, Kathy Mulgrew, Ankita Mishra, Gordon Moody, Maja Sedic, Joshua Frederick, John Zielinski, Fabien Garcon, Sushma Gurumurthy, Nadia Luheshi, Michal Sulikowski, Steve Novick, Han Si, Philip Martin, Grace Adjei, James Moynihan, Jean-Martin Lapointe, Amanda Watkins, Shannon Burke, Ronald Herbst, Dyane Bailey, Robert W. Wilkinson
Publikováno v:
Clinical Cancer Research. 26:6284-6298
Purpose: While immune checkpoint inhibitors such as anti–PD-L1 are rapidly becoming the standard of care in the treatment of many cancers, only a subset of treated patients have long-term responses. IL12 promotes antitumor immunity in mouse models;
Publikováno v:
Clinical Cancer Research. 26:332-339
Tumors evolve in close interaction with their microenvironment, which encompasses a continual tension between the developing tumor and the host immune system. Clinical trials have shown that appropriate enhancement of a tumor immune response can lead
Autor:
Jay Harper, Ravinder Tammali, David A. Tice, Brandon W. Higgs, Nicholas Holoweckyj, Christine Fazenbaker, Jing Zhang, James Conway, Cui Chen, Shannon Breen, Haihong Zhong, Maureen Kennedy, Andrew J. Pierce, Ronald Herbst, Rajiv Raja
Publikováno v:
Molecular Cancer Therapeutics. 18:89-99
Pyrrolobenzodiazepine dimers (PBD) form cross-links within the minor groove of DNA causing double-strand breaks (DSB). DNA repair genes such as BRCA1 and BRCA2 play important roles in homologous recombination repair of DSB. We hypothesized that PBD-b
Autor:
Philip Howard, Cui Tracy Chen, Haihong Zhong, Nazzareno Dimasi, John Meekin, Paul Hynes, David A. Tice, Kenneth C. Anderson, Elaine M. Hurt, Xiaodong Xiao, Krista Kinneer, Reena Varkey, Yu-Tzu Tai, Ronald Herbst, Ryan Fleming, Shannon Breen, Suneetha Thomas, Binyam Bezabeh, Leslie Wetzel, Ruoyan Chen, Matt Flynn
Publikováno v:
Leukemia. 33:766-771
Autor:
Luke A. Masterson, Sonja Hess, Howard Philip Wilson, Andrew Garcia, Kimberly M Cook, Kathryn M. Pugh, Wen Yu, Hong Chen, Allison M. Barrett, Ronald Herbst, Shenlan Mao, Changshou Gao, David A. Tice, Mark Cobbold, Herren Wu, Jens-Oliver Koopmann, Ryan Fleming, Jay Harper, Susan Wilson, Raghothama Chaerkady, Gina DAngelo, Sandrina Phipps, Nazzareno Dimasi
Publikováno v:
Molecular cancer therapeutics. 20(3)
Resistance to antibody–drug conjugates (ADCs) has been observed in both preclinical models and clinical studies. However, mechanisms of resistance to pyrrolobenzodiazepine (PBD)-conjugated ADCs have not been well characterized and thus, this study
Autor:
Ashenafi Y. Tilahun, Andrew Leishman, Richard J. A. Goodwin, John P. Vasilakos, Robert W. Wilkinson, John G. Swales, Nadia Luheshi, Elina Timosenko, Ronald Herbst, James Elvecrog, Stefanie R. Mullins, Simon J. Dovedi, Pete Gillis, Zachary A. Cooper, Iwen Grigsby, Katharina Deschler, Julius John, Matthew J. Elder, Mark A. Tomai
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-18 (2019)
Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-18 (2019)
Background Immune checkpoint blockade (ICB) promotes adaptive immunity and tumor regression in some cancer patients. However, in patients with immunologically “cold” tumors, tumor-resident innate immune cell activation may be required to prime an
Autor:
John Meekin, Haihong Zhong, Maureen Kennedy, Rosa A. Carrasco, Ronald Herbst, Sandrina Phipps, Binyam Bezabeh, R. James Christie, Karma Dacosta, David A. Tice, Emily E. Bosco, Jiping Zha, Rakesh Dixit, Partha S. Chowdhury, Joanne Ayriss, Qun Du, Zhan Xiao, Darrin Sabol, MaryJane Hinrichs, Cui Chen, Shannon Breen, Lee Brown, Molly Reed
Publikováno v:
Oncotarget
Despite recent advances in treatment, breast cancer remains the second-most common cause of cancer death among American women. A greater understanding of the molecular characteristics of breast tumors could ultimately lead to improved tumor-targeted
Autor:
Theodore H. Welling, Kathryn E. Luker, Robert E. Hollingsworth, Ronald Herbst, Judith S. Sebolt-Leopold, Jonathan Rios-Doria, Eric R. Fearon, Elizabeth Ziemke, Matt Flynn, Joseph Dosch, Suneetha Thomas, Elaine M. Hurt, Karin M. Hardiman, Shanshan Wan
Publikováno v:
Oncotarget
// Joseph Dosch 1, * , Elizabeth Ziemke 1, * , Shanshan Wan 2 , Kathryn Luker 1 , Theodore Welling 2 , Karin Hardiman 2 , Eric Fearon 3 , Suneetha Thomas 4 , Matthew Flynn 4 , Jonathan Rios-Doria 4 , Robert Hollingsworth 4 , Ronald Herbst 4 , Elaine
Autor:
Marco Alifano, Bastien Rance, Audrey Mansuet-Lupo, Hélène Blons, M. Wislez, Jérôme Biton, Pierre Laurent-Puig, Jean-François Regnard, Ronald Herbst, Y. Velut, Makmoud Zarmaev, Marc Barritault, Aurélie Janet-Vendroux, Isabelle Cremer, Ludovic Fournel, Christine Le Hay, Diane Damotte
Publikováno v:
Journal of Thoracic Oncology
Journal of Thoracic Oncology, Lippincott, Williams & Wilkins, 2019, 14, pp.844-856. ⟨10.1016/j.jtho.2019.01.017⟩
Journal of Thoracic Oncology, Lippincott, Williams & Wilkins, 2019, 14, pp.844-856. ⟨10.1016/j.jtho.2019.01.017⟩
Introduction Multiple nodules in the lung are being diagnosed with an increasing frequency thanks to high-quality computed tomography imaging. In patients with lung cancer, this situation represents up to 10% of patients who have an operation. For cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f64f0e5b5077fa6511fbf1b058399b
https://hal.archives-ouvertes.fr/hal-03486393/file/S1556086419300930.pdf
https://hal.archives-ouvertes.fr/hal-03486393/file/S1556086419300930.pdf
Autor:
Isharat Yusuf, Stacey Drabic, Albulescu Marius, Melissa de los Reyes, Rachel Ettinger, Manuel Baca, Jodi L. Karnell, Li Yan, Ximing Xiong, Thomas Thisted, L. Wang, Ulf Müller-Ladner, David Howe, Jing Li, Jorn Drappa, Steven Eck, Rachel Moate, Ronald Herbst, Michele Gunsior, Katie Streicher, Vaheh Oganesyan
Publikováno v:
Science Translational Medicine. 11
The CD40/CD40L axis plays a central role in the generation of humoral immune responses and is an attractive target for treating autoimmune diseases in the clinic. Here, we report the generation and clinical results of a CD40L binding protein, VIB4920