Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Robert Somerville"'
Autor:
Scott Kivitz, Gal Cafri, Drew C. Deniger, Steven A. Rosenberg, Parisa Malekzadeh, Paul F. Robbins, Biman C. Paria, Rami Yossef, Mark Raffeld, Nicholas P. Restifo, Amy R. Copeland, Satyajit Ray, Maria R. Parkhurst, Robert Somerville, Sang-hyun Kim, Meghan L. Good, Zhiya Yu, Abraham Sachs, Liqiang Xi, Frank J. Lowery, Mohammad S. Jafferji
Publikováno v:
Clin Cancer Res
Purpose: The purpose of this study was to evaluate antigen experienced T cells in peripheral blood lymphocytes (PBL) for responses to p53 neoantigens. Experimental Design: PBLs from patients with a mutated TP53 tumor were sorted for antigen-experienc
Autor:
Harshini Chinnasamy, Todd D. Prickett, Li Jia, Paul F. Robbins, Isaac R. Kriley, Yasmine Assadipour, Steven A. Rosenberg, Steven A. Feldman, Stephanie L. Goff, Jared J. Gartner, Nikolaos Zacharakis, Jessica S. Crystal, John R. Wunderlich, Yong-Chen Lu, Robert Somerville, Mary A. Black, Lily Lu, Hui Xu, Zhili Zheng
Publikováno v:
Clinical Cancer Research. 23:4347-4353
Purpose: The administration of autologous tumor-infiltrating lymphocytes (TILs) can mediate durable tumor regressions in patients with melanoma likely based on the recognition of immunogenic somatic mutations expressed by the cancer. There are limite
Autor:
Steven A. Rosenberg, Arvind Sabesan, John R. Wunderlich, David N. Danforth, Christopher A. Klebanoff, Stephanie L. Goff, Mary Ann Toomey, Liqiang Xi, Daniel Zlott, Robert Somerville, James Chih-Hsin Yang, Mark Raffeld, Donald E. White, Trinh Hoc Tran Pham, Smita S. Chandran, Richard M. Sherry, Abhishek K. Srivastava, Udai S. Kammula, Biman C. Paria
Publikováno v:
The Lancet Oncology. 18:792-802
Summary Background Uveal melanoma is a rare tumour with no established treatments once metastases develop. Although a variety of immune-based therapies have shown efficacy in metastatic cutaneous melanoma, their use in ocular variants has been disapp
Autor:
John R. Wunderlich, Paul F. Robbins, Anna Pasetto, Li Jia, Mona El-Gamil, Gal Cafri, Maria R. Parkhurst, Eric Tran, Yong F. Li, Lien T. Ngo, Winifred Lo, Robert Somerville, Mojgan Ahmadzadeh, Jessica S. Crystal, Todd D. Prickett, Gabriel Ivey, Satyajit Ray, Frank J. Lowery, Rami Yossef, Abraham Sachs, Steven A. Rosenberg, Almin Lalani, Scott Kivitz, Eric M. Groh, Drew C. Deniger, Parisa Malekzadeh, Stephanie L. Goff, Jared J. Gartner
Publikováno v:
Cancer discovery. 9(8)
Immunotherapies can mediate regression of human tumors with high mutation rates, but responses are rarely observed in patients with common epithelial cancers. This raises the question of whether patients with these common cancers harbor T lymphocytes
Autor:
John R. Wunderlich, Robert Somerville, Udai S. Kammula, James Chih-Hsin Yang, Richard M. Sherry, Steven A. Rosenberg, Sarah R. Helman, Mei Li M. Kwong, Michelle M. Langhan, Christopher A. Klebanoff, Stacey L. Doran, Christian S. Hinrichs, Sanja Stevanović
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(5)
Purpose: Cellular therapy is an emerging cancer treatment modality, but its application to epithelial cancers has been limited. This clinical trial evaluated tumor-infiltrating lymphocyte (TIL) therapy for the treatment of patients with metastatic hu
Autor:
John R. Wunderlich, Daniel J. Stephens, Liqiang Xi, Biman C. Paria, Smita S. Chandran, Arvind Sabesan, Mark Raffeld, Parthav Jailwala, Manjula Kasoji, Robert Somerville, Chyi-Chia Richard Lee, Trinh Hoc Tran Pham, Luke D. Rothermel, Abhishek K. Srivastava, Udai S. Kammula
Publikováno v:
Clinical Cancer Research. 22:2237-2249
Purpose: Uveal melanoma is a rare melanoma variant with no effective therapies once metastases develop. Although durable cancer regression can be achieved in metastatic cutaneous melanoma with immunotherapies that augment naturally existing antitumor
Autor:
Y Assadipour, Steven A. Feldman, Todd D. Prickett, Mary A. Black, John R. Wunderlich, Harshini Chinnasamy, M Statler, Paul F. Robbins, Stephanie L. Goff, Hui Xu, I Kriley, Lily Lu, Nikolaos Zacharakis, Robert Somerville, Steven A. Rosenberg, Jared J. Gartner
Publikováno v:
Cancer Research. 77:P2-04
Background & Translational Relevance: Adoptive transfer of tumor infiltrating lymphocytes (TIL) can effect long-term durable regression in patients with metastatic melanoma but has not been widely tested in common epithelial cancers. When examining t
Autor:
Anna Pasetto, Zhili Zheng, Paul F. Robbins, Jared J. Gartner, Steven A. Feldman, Harshini Chinnasamy, Michelle M. Langhan, Stephanie L. Goff, Nikolaos Zacharakis, Li Jia, Yong-Chen Lu, Steven A. Rosenberg, Katarzyna Trebska-McGowan, Todd D. Prickett, Hui Xu, Robert Somerville, Mary A. Black, Thomas E. Shelton
Immunotherapy using either checkpoint blockade or the adoptive transfer of antitumor lymphocytes has shown effectiveness in treating cancers with high levels of somatic mutations—such as melanoma, smoking-induced lung cancers and bladder cancer—w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbc31464c573e58f95d626fcf15186b8
https://europepmc.org/articles/PMC6348479/
https://europepmc.org/articles/PMC6348479/
Autor:
Norris Lam, Steven A. Rosenberg, John J. Rossi, James N. Kochenderfer, Adrian Bot, Robert Somerville, James Chih-Hsin Yang, Richard M. Sherry, Steven A. Feldman, Lori McIntyre, Tangying Lu
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 25(10)
T cells expressing anti-CD19 chimeric antigen receptors (CARs) can induce complete remissions (CRs) of diffuse large B cell lymphoma (DLBCL). The long-term durability of these remissions is unknown. We administered anti-CD19 CAR T cells preceded by c
Autor:
Lori McIntyre, Jonathan W. Friedberg, Mark Roschewski, Udai S. Kammula, Stephanie L. Goff, Christopher A. Klebanoff, Richard M. Sherry, Robert Somerville, James N. Kochenderfer, Adrian Bot, Steven A. Feldman, Marika Sherman, Tatyana Feldman, Victoria Shi, Steven A. Rosenberg, Tangying Lu, Arianne Perez, John J. Rossi, Mary Ann Toomey, James Chih-Hsin Yang, Constance M. Yuan, Allen Xue
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 35(16)
Purpose T cells genetically modified to express chimeric antigen receptors (CARs) targeting CD19 (CAR-19) have potent activity against acute lymphoblastic leukemia, but fewer results supporting treatment of lymphoma with CAR-19 T cells have been publ