Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Manal F. Abdelmalek"'
Autor:
Anna Mae Diehl, Ning-Ping Zhang, Ying Wang, Chen Yang, Xiuping Liu, Xue-Jing Liu, Wen‐Yue Dong, Chang Liu, Li Xie, Manal F. Abdelmalek, Jian Wu, Chenjian Gu, Kuo Du, Chen Niu
Publikováno v:
Liver Int
Background and aims Treatment of non-alcoholic steatohepatitis (NASH) is challenging, because suppressing fibrotic progression has not been achieved consistently by drug candidates currently in clinical trials. The aim of this study was to investigat
Autor:
Jun Zhang, Roger J. Davis, Meng Li, Christopher Q. Chen, Anna Mae Diehl, Mariam Aghajan, Ying Wang, Robert Win Maw Min, Tin Aung Than, Sanda Win, Neil Kaplowitz, Yibu Chen, Manal F. Abdelmalek, Filbert W.M. Aung, Ayako Suzuki
Publikováno v:
Journal of Clinical Investigation. 129:5278-5293
SH3 domain–binding protein that preferentially associates with Btk (SAB) is an outer-membrane docking protein for JNK-mediated impairment of mitochondrial function. Deletion of Sab in hepatocytes inhibits sustained JNK activation and cell death. Th
Autor:
Manal F. Abdelmalek, Keri A. Seymour
Publikováno v:
Current opinion in gastroenterology. 37(3)
Purpose of review Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in the United States and increasing globally. The progressive form of NAFLD, nonalcoholic steatohepatitis (NASH), can lead to cirrhosis and compl
Autor:
Rajanshu Verma, Naga Swetha Samji, Mary E. Rinella, Ashwani K. Singal, Aijaz Ahmed, Krishna C. Keri, David I. Bernstein, Manal F. Abdelmalek, Sanjaya K. Satapathy
Publikováno v:
Digestive Diseases and Sciences. 64:3413-3430
Nonalcoholic steatohepatitis is the fastest-growing indication for the liver transplant and a leading cause of hepatocellular carcinoma among patients listed for liver transplantation in the USA. Post-transplant nonalcoholic hepatic steatosis and ste
Autor:
Anna Mae Diehl, Nezam H. Afdhal, Andrew J. Muir, Jaime Bosch, G. Mani Subramanian, Zachary Goodman, Raul Aguilar Schall, Arun J. Sanyal, Stephen A. Harrison, Stephen H. Caldwell, B. Mccolgan, Maria Stepanova, Manal F. Abdelmalek, Robert P. Myers, Vlad Ratziu, Zobair M. Younossi, Mitchell L. Shiffman
Publikováno v:
Journal of Hepatology. 69:1365-1370
Although patients with cryptogenic cirrhosis have historically been considered as having "burnt-out" non-alcoholic steatohepatitis (NASH), some controversy remains. The aim of this study was to compare outcomes of patients with cryptogenic cirrhosis
Autor:
Wing-Kin Syn, Keyur Patel, Cynthia D. Guy, Anna Mae Diehl, Robert D. Streilein, Ricardo Henao, Oliver Glass, Hans J Gruss, Manal F. Abdelmalek, Cynthia A. Moylan, Russell P. Hall
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 2, Iss 11, Pp 1344-1355 (2018)
Hepatology Communications, Vol 2, Iss 11, Pp 1344-1355 (2018)
The severity of hepatic fibrosis is the primary predictor of liver‐related morbidity and mortality in patients with nonalcoholic fatty liver disease (NAFLD). Unfortunately, noninvasive serum biomarkers for NAFLD‐associated fibrosis are limited. W
Autor:
Paul Y. Kwo, David I. Bernstein, Zobair M. Younossi, Ziad Younes, Mazen Noureddin, Manal F. Abdelmalek, Mark W. Russo, Mitchell L. Shiffman
Publikováno v:
The American journal of gastroenterology. 116(2)
Nonalcoholic fatty liver disease (NAFLD) is generally considered a silent and potentially reversible condition. The subtype of NAFLD that can be classified as nonalcoholic steatohepatitis (NASH) can progress to advanced fibrosis and cirrhosis. Becaus
Autor:
Laura A. Wilson, James Tonascia, Jeanne M. Clark, Srinivasan Dasarathy, Brent A. Neuschwander-Tetri, David E. Kleiner, Manal F. Abdelmalek, Bilal Hameed, Oscar W. Cummings, Arun J. Sanyal, Rohit Loomba, Kris V. Kowdley, Samer Gawrieh, Edward Doo, Naga Chalasani
Publikováno v:
Am J Gastroenterol
OBJECTIVES Patients with nonalcoholic fatty liver disease (NAFLD) and normal aminotransferase levels may have advanced liver histology. We conducted a study to characterize the prevalence of and factors associated with advanced liver histology in pat
Autor:
Kris V. Kowdley, Mark L. Van Natta, Arun J. Sanyal, James Tonascia, Edward Doo, Raj Vuppalanchi, Mohammad S. Siddiqui, David E. Kleiner, Manal F. Abdelmalek, Rohit Loomba, Danielle Brandman, Erin Hallinan, Brent A. Neuschwander-Tetri, Srinivas Dasarathy, Naga Chalasani
Publikováno v:
Hepatology. 67:134-144
Vibration-controlled transient elastography estimates liver stiffness measurement (LSM) and controlled attenuation parameter (CAP), which are noninvasive assessments of hepatic fibrosis and steatosis, respectively. However, prior vibration-controlled
Autor:
Laura A. Wilson, Nathan M. Bass, Ayako Suzuki, Ryan M. Gill, Norah A. Terrault, Marcelle I. Cedars, Manal F. Abdelmalek, Monika Sarkar, Katherine P. Yates
Publikováno v:
Clin Gastroenterol Hepatol
BACKGROUND: Higher testosterone contributes to imaging-confirmed nonalcoholic fatty liver disease (NAFLD) in women, but whether testosterone influences their disease severity is unknown. METHODS: The association of free testosterone (free T) with non