Zobrazeno 1 - 10
of 34
pro vyhledávání: '"M. Solis"'
Autor:
Guangchun Han, Warapen Treekitkarnmongkol, Ansam Sinjab, Tina Cascone, Jichao Chen, Humam Kadara, Ignacio I. Wistuba, Christopher S. Stevenson, Paul Scheet, Edwin R. Parra, Patrick M. Brennan, Luisa M. Solis, Carmen Behrens, Daniel G. Rosen, Jianjun Zhang, Danielle R. Little, Dapeng Hao, Beatriz Sanchez-Espiridion, Ruiping Wang, Linh M. Tran, Kostyantyn Krysan, Junya Fujimoto, John V. Heymach, Seyed Javad Moghaddam, Kieko Hara, Samer Bazzi, Minghao Dang, Avrum Spira, Kyle Chang, Dzifa Y. Duose, Don L. Gibbons, Boris Sepesi, Steven M. Dubinett, Linghua Wang, Elena Bogatenkova, Edwin J. Ostrin, Maria Gabriela Raso, Lauren Averett Byers, Jiexin Zhang, Hitoshi Dejima, Enyu Dai, Junya Fukuoka
Publikováno v:
Cancer Discov
Little is known of the geospatial architecture of individual cell populations in lung adenocarcinoma (LUAD) evolution. Here, we perform single-cell RNA sequencing of 186,916 cells from five early-stage LUADs and 14 multiregion normal lung tissues of
Autor:
John V. Heymach, Barbara Mino, J. Jack Lee, Pedro Rocha, Cesar A. Moran, David C. Rice, Edwin R. Parra, Humam Kadara, Boris Sepesi, Lei Feng, Luisa M. Solis, Carmen Behrens, Ignacio I. Wistuba, Don L. Gibbons, Jianjun Zhang, Chad J. Creighton, Jaime Rodriguez-Canales
Publikováno v:
Clinical Lung Cancer. 22:e415-e424
Introduction Immune infiltration in lung adenocarcinomas (LUADs) has been associated with response to immune checkpoint inhibitors. Clinical features underlying differential responses of patients with LUADs to immunotherapy are not well understood. H
Autor:
Runzhe Chen, Boris Sepesi, Jie Ye, J. Jack Lee, John V. Heymach, Junya Fujimoto, Baili Zhang, Nicholas McGranahan, Jianhua Zhang, Latasha Little, Junya Fukuoka, Harvey I. Pass, Dzifa Y. Duose, Chi Wan Chow, Hitoshi Dejima, Kazuhiro Tabata, Humam Kadara, Alexandre Reuben, Marcos R. Estecio, Jiexin Zhang, Xin Hu, Ara A. Vaporciyan, Jia Wu, Lisha Ying, Curtis Gumbs, Hoa H.N. Pham, Paul Scheet, Myrna C.B. Godoy, Carmen Behrens, Cara Haymaker, P. Andrew Futreal, Dan Su, Jianjun Zhang, Luisa M. Solis, Shawna M Hubert, Edwin R. Parra, Ignacio I. Wistuba, Mara B. Antonoff
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The mechanism by which anti-cancer immunity shapes early carcinogenesis of lung adenocarcinoma (ADC) is unknown. In this study, we characterize the immune contexture of invasive lung ADC and its precursors by transcriptomic immune profiling, T cell r
Autor:
Lixia Diao, Esra A. Akbay, Linghua Wang, Won-Chul Lee, Kwok-Kin Wong, Don L. Gibbons, Luisa M. Solis Soto, Ruiping Wang, Stephen G. Swisher, Jing Wang, Runzhe Chen, Roohussaba Khairullah, You Hong Fan, Alexandre Reuben, Mingrui Zhu, Jack A. Roth, Boris Sepesi, Irene Guijarro Munoz, John V. Heymach, Carmen Behrens, Jianhua Zhang, Jacqulyne P. Robichaux, Marcelo V. Negrao, Humam Kadara, Edwin R. Parra, Monique B. Nilsson, Lorenzo Federico, Tatiana Karpinets, Ignacio I. Wistuba, Chantale Bernatchez, Jianjun Zhang, Daniel J. McGrail, S. Patel, Xiuning Le, Ara A. Vaporciyan, Yasir Elamin, Cara Haymaker, Jun Li, Lauren Averett Byers
Publikováno v:
Journal of Thoracic Oncology. 16:583-600
Introduction Lung adenocarcinomas harboring EGFR mutations do not respond to immune checkpoint blockade therapy and their EGFR wildtype counterpart. The mechanisms underlying this lack of clinical response have been investigated but remain incomplete
Autor:
Tieling Zhou, Lin Tian, Melisa Martinez-Paniagua, Rama Soundararajan, Jeffrey T. Chang, Luisa M. Solis, Barbara Mino, Sevinj Isgandarova, Ignacio I. Wistuba, Don L. Gibbons, Kendra Allton, Robiya Joseph, Xiang Zhang, Jaime Rodriguez-Canales, Michelle Craig Barton, Anil K. Sood, Crystal S. Shin, Fei Yang, Aysegul A. Sahin, Monika Haemmerle, Juri G. Gelovani, Petra den Hollander, Ghanashyam Acharya, Sendurai A. Mani, Jeffrey M. Rosen, Suhas Vasaikar, Navin Varadarajan
Publikováno v:
British Journal of Cancer
Background The mechanism by which immune cells regulate metastasis is unclear. Understanding the role of immune cells in metastasis will guide the development of treatments improving patient survival. Methods We used syngeneic orthotopic mouse tumour
Autor:
Cheuk Hong Leung, Wayne L. Hofstetter, John V. Heymach, Alexandre Reuben, Myrna C.B. Godoy, Ara A. Vaporciyan, Padmanee Sharma, Yasir Elamin, Neda Kalhor, Robert R. Jenq, Junya Fujimoto, Tina Cascone, Anne S. Tsao, William N. William, Charles Lu, Frank E. Mott, Nadim J. Ajami, Don L. Gibbons, Jack A. Roth, David C. Rice, Luisa M. Solis, Hai T. Tran, Brett W. Carter, Lauren Averett Byers, Andrew Futreal, Lorenzo Federico, Annikka Weissferdt, Garrett L. Walsh, Reza J. Mehran, Chantale Bernatchez, George R. Blumenschein, Jennifer A. Wargo, Heather Lin, Cara Haymaker, Xiuning Le, Jonathan M. Kurie, Mehmet Altan, James P. Allison, Stephen G. Swisher, Edwin R. Parra, Boris Sepesi, Hitoshi Dejima, Frank V. Fossella, Jianjun Zhang, Bonnie S. Glisson, Mara B. Antonoff, Abdul Wadud Khan, Apar Pataer, Alejandro Francisco-Cruz, Ignacio I. Wistuba, Humam Kadara, J. Jack Lee, Ferdinandos Skoulidis
Publikováno v:
Nat Med
Ipilimumab improves clinical outcomes when combined with nivolumab in metastatic non-small cell lung cancer (NSCLC), but its efficacy and impact on the immune microenvironment in operable NSCLC remain unclear. We report the results of the phase 2 ran
Autor:
Pedro Rocha, Dzifa Y. Douse, Lixia Diao, Humam Kadara, Jianjun Zhang, Debora A. Ledesma, Jose Luis Solorzano, John V. Heymach, Ruth Salazar, Luisa M. Solis, Neda Kalhor, Barbara Mino, J. Jack Lee, Don L. Gibbons, Cesar A. Moran, David C. Rice, Carmen Behrens, Pamela Villalobos, Ara A. Vaporciyan, Jiexin Zhang, Hitoshi Dejima, Annikka Weissferdt, Kyle G. Mitchell, Tina Cascone, Edwin Parra-Cuentas, Boris Sepesi, Xiuning Le, Ignacio I. Wistuba
Publikováno v:
Cancer Immunology, Immunotherapy
Introduction CD73 is a membrane-bound enzyme crucial in adenosine generation. The adenosinergic pathway plays a critical role in immunosuppression and in anti-tumor effects of immune checkpoint inhibitors (ICI). Here, we interrogated CD73 expression
Autor:
Robert Tyler Hillman, Gloria Salvo, Preetha Ramalingam, Lauren Averett Byers, Junya Fujimoto, Robert J. Cardnell, Natacha Phoolcharoen, Luisa M. Solis Soto, Matthew Carroll, Michael Frumovitz
Publikováno v:
Int J Gynecol Cancer
ObjectivesWomen with recurrent high-grade neuroendocrine cervical cancer have few effective treatment options. The aim of this study was to identify potential therapeutic targets for women with this disease.MethodsSpecimens from patients with high-gr
Publikováno v:
Virchows Archiv. 477:437-444
Hodgkin lymphoma is a B cell neoplasm characterized by Hodgkin and Reed-Sternberg (HRS) cells in an inflammatory background. Classic Hodgkin lymphoma (CHL) accounts for approximately 90% of all cases of HL and four types are recognized in the World H
Autor:
Wei Lu, Ignacio I. Wistuba, David W. Cescon, Lin Zheng, Tak W. Mak, Pamela Villalobos, Jennifer Silvester, Lisa Maria Mustachio, Barbara Mino, Ethan Dmitrovsky, Luisa M. Solis, Zibo Chen, Masanori Kawakami, Kelsie L. Thu, Xi Liu, Carmen Behrens, Jonathan M. Kurie, Yulong Chen, Jaime Rodriguez-Canales, Jason Roszik
Publikováno v:
Molecular Cancer Therapeutics. 18:1775-1786
The spindle assembly checkpoint maintains genomic integrity. A key component is tyrosine threonine kinase (TTK, also known as Mps1). TTK antagonism is hypothesized to cause genomic instability and cell death. Interrogating The Cancer Genome Atlas rev