Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Lucia Knopfová"'
Autor:
Sára Lenárt, Peter Lenárt, Lucia Knopfová, Hana Kotasová, Vendula Pelková, Veronika Sedláková, Vladimír Čan, Jan Šmarda, Karel Souček, Aleš Hampl, Petr Beneš
TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody-drug conjugate targeting Trop2 were recently approved cancer therapy, the physiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7f1ccc011d8be1bda0430a0a7ec71ed
https://doi.org/10.1101/2021.06.29.450320
https://doi.org/10.1101/2021.06.29.450320
Autor:
Petr Beneš, Jiří Jarkovský, Jana Katolická, Ivan Čapov, Jan Šmarda, Petr Vlček, Tichý M, Markéta Hermanová, Lucia Knopfová
Publikováno v:
Journal of Cancer
Colorectal cancer (CRC) represents a serious challenge for oncologists due to high incidence and large heterogeneity. Prognostic factors are needed to stratify patients according to risk of disease progression. In this study, we report that high expr
Overexpression of c-Myb is associated with suppression of distant metastases in colorectal carcinoma
Autor:
Lenka Veverková, Jiří Jarkovský, Ivan Čapov, Petr Beneš, Jana Katolická, Jan Šmarda, Markéta Hermanová, Lucie Pekarčíková, Petr Vlček, Tichý M, Lucia Knopfová
Publikováno v:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
The MYB gene codes for the c-Myb transcription factor maintaining proliferation of colon epithelial progenitors, thus controlling colon development and homeostasis. This gene is overexpressed in early phases of colorectal cancer (CRC) tumorigenesis.
Publikováno v:
Cellular signalling
The c-Myb transcription factor is important for maintenance of immature cells of many tissues including colon epithelium. Overexpression of c-Myb occurring in colorectal carcinomas (CRC) as well as in other cancers often marks poor prognosis. However
Autor:
Lubor Borsig, Cristina Stefanescu, Lucia Knopfová, Jesus Francisco Glaus Garzon, Darya Protsyuk, Christian Gorzelanny, Bruno Luckow, Marko Roblek, Stefan W. Schneider, Mathias Heikenwalder, Paul F. Becker
Publikováno v:
Mol. Cancer Res. 17, 783-793 (2019)
Increased levels of the chemokine CCL2 in cancer patients are associated with poor prognosis. Experimental evidence suggests that CCL2 correlates with inflammatory monocyte recruitment and induction of vascular activation, but the functionality remai
Autor:
Pavel Kopel, Lukas Nejdl, Lucia Knopfová, Markéta Sztalmachová, Martina Raudenská, Marie Stiborová, Michal Masarik, Jana Vlachova, René Kizek, Michaela Fojtu, Vojtech Adam, Petr Babula, Anna Skotakova, Sylvie Skalickova, Jaromír Gumulec
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 12, Pp 22960-22977 (2014)
International Journal of Molecular Sciences. 2014, vol. 15, issue 12, p. 22960-22977.
International Journal of Molecular Sciences
Volume 15
Issue 12
Pages 22960-22977
International Journal of Molecular Sciences. 2014, vol. 15, issue 12, p. 22960-22977.
International Journal of Molecular Sciences
Volume 15
Issue 12
Pages 22960-22977
Doxorubicin is an effective chemotherapeutic drug, however, its toxicity is a significant limitation in therapy. Encapsulation of doxorubicin inside liposomes or ferritin cages decreases cardiotoxicity while maintaining anticancer potency. We synthes
Autor:
Michal Masarik, Veronika Dvorakova, Martina Raudenská, Hana Polanska, René Kizek, Vojtech Adam, Jaromír Gumulec, Kristyna Hudcova, Lucia Knopfová, Jan Balvan, Petr Babula, Branislav Ruttkay-Nedecky, Marie Stiborová, Markéta Sztalmachová
Publikováno v:
International Journal of Oncology. 44:923-933
Differences in the antioxidant system, apoptotic mechanism and in cell cycle between prostatic cell lines could partially elucidate the development of cisplatin resistance. The aim of this study was to identify the most characteristic parameter for a
Publikováno v:
Cellular Signalling. 25:1546-1555
Nuclear factors of activated T-cells (NFATs) are important regulators of the cytokine gene expression in activated T-cells. In the last decade, NFATs have been shown to regulate cell cycle, differentiation and apoptosis in cells of various origins re
Autor:
Lucia Knopfová, Vlasta Lungová, Eva Matalová, Jan Šmarda, Marcela Buchtová, Eva Janečková, Abigail S. Tucker
Publikováno v:
European Journal of Oral Sciences. 120:495-504
The MYB family of transcription activators has been associated with a high proliferation rate and an undifferentiated state of cells in a number of tissues. Recently emerging data suggest that these molecules may also play a role in differentiation.
Publikováno v:
Environmental and Molecular Mutagenesis. 53:515-524
Wedelolactone is one of the active plant polyphenolic compounds. Anti-tumor effects of this drug have been demonstrated recently. We have described that wedelolactone acts as catalytic inhibitor of DNA topoisomerase IIα. The aim of this study was to