Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Karel Souček"'
Autor:
Sára Lenárt, Peter Lenárt, Lucia Knopfová, Hana Kotasová, Vendula Pelková, Veronika Sedláková, Vladimír Čan, Jan Šmarda, Karel Souček, Aleš Hampl, Petr Beneš
TACSTD2 encodes a transmembrane glycoprotein Trop2 commonly overexpressed in carcinomas. While the Trop2 protein was discovered already in 1981 and first antibody-drug conjugate targeting Trop2 were recently approved cancer therapy, the physiological
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7f1ccc011d8be1bda0430a0a7ec71ed
https://doi.org/10.1101/2021.06.29.450320
https://doi.org/10.1101/2021.06.29.450320
Publikováno v:
Cancers
Cancers, Vol 13, Iss 2188, p 2188 (2021)
Cancers, Vol 13, Iss 2188, p 2188 (2021)
Simple Summary Epithelial–mesenchymal transition (EMT) and its reverse process mesenchymal–epithelial transition (MET) are considered critical events in the cancer progression. These programs are tightly connected with the development of metastas
Autor:
Daniela Kurfürstová, Milan Král, Alena Mickova, Jan Bouchal, Barbora Pokryvkova, Mariam Gachechiladze, Ondrej Vacek, Karel Souček, Martin Mistrik, Gvantsa Kharaishvili
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 2844, p 2844 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 6
International Journal of Molecular Sciences
Volume 22
Issue 6
Prostate cancer (PCa) is the second leading cause of cancer-related deaths in men in Western countries, and there is still an urgent need for a better understanding of PCa progression to inspire new treatment strategies. Skp2 is a substrate-recruitin
Autor:
Vondálová Blanářová O, Karel Souček, Michaela Nosková, Víchová R, Kristína Gömöryová, Gybel’ T, Zbynek Zdrahal, Karol Kaiser, Lucia Kucerova, Lucia Demkova, Bryja, David Potěšil, Katarzyna Anna Radaszkiewicz, Markéta Pícková, Tomasz Witold Radaszkiewicz
RNF43 is a E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also regulator of noncanonical WNT5A-induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunopreci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::259dd6982413886159ca97f70622272a
https://doi.org/10.1101/2021.02.08.430210
https://doi.org/10.1101/2021.02.08.430210
Autor:
Lucie Jurečková, Veronika Pospíšilová, Petr Vaňhara, Aleš Hampl, Zuzana Holubcová, Vendula Pelková, Daniela Mináriková, Tomáš Bárta, Karel Souček, Dáša Bohačiaková, Volodymyr Porokh
Publikováno v:
Stem Cells and Development. 27:1077-1084
Chromosomal instability evoked by abnormalities in centrosome numbers has been traditionally considered as a hallmark of aberrant, typically cancerous or senescent cells. We have reported previously that pristine human embryonic stem cells (hESC) suf
Autor:
Jan Bouchal, Wytske M. van Weerden, Vladimír Študent, Zoran Culig, Martin Morong, Stanislav Drápela, Daniela Kurfürstová, Barbora Kvokackova, Radek Fedr, Martin Puhr, Karel Souček
BackgroundDocetaxel resistance represents a leading obstacle in the therapy of prostate cancer (PCa), resulting in lethal disease. Intratumoral heterogeneity, which is frequently driven by epithelial-mesenchymal plasticity significantly contributes t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c06e0a02611c88c6759b3e22b9c27403
https://doi.org/10.1101/2021.01.28.428577
https://doi.org/10.1101/2021.01.28.428577
Autor:
Zbyněk Zdráhal, Olga Vondálová Blanářová, Tomáš Gybeľ, Markéta Pícková, Lucia Kucerova, Ráchel Víchová, Kristína Gömöryová, Tomasz Witold Radaszkiewicz, Karol Kaiser, Vítězslav Bryja, David Potěšil, Tomáš Bárta, Michaela Nosková, Karel Souček, Lucia Demkova, Katarzyna Anna Radaszkiewicz
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
RNF43 is an E3 ubiquitin ligase and known negative regulator of WNT/β-catenin signaling. We demonstrate that RNF43 is also a regulator of noncanonical WNT5A-induced signaling in human cells. Analysis of the RNF43 interactome using BioID and immunopr
Publikováno v:
Cancers
Cancers, Vol 12, Iss 3227, p 3227 (2020)
Cancers, Vol 12, Iss 3227, p 3227 (2020)
Simple Summary Toll-like receptor 3 (TLR3) is a member of the TLR family, which has been extensively studied for the antiviral function and, therefore, its role in the innate and adaptive immune responses. It is highly expressed in the endosomes of a
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences
The predominant way in which conventional chemotherapy kills rapidly proliferating cancer cells is the induction of DNA damage. However, chemoresistance remains the main obstacle to therapy effectivity. An increasing number of studies suggest that ep
Autor:
Petr Dzubak, Zuzana Kahounová, Jiri Navratil, Dana Simkova, Gabriela Korinkova, Adéla Galandáková, Tereza Suchankova-Kleplova, Karel Souček, Tomáš Soukup, Jan Bouchal, Tomas Ozdian, Gvantsa Kharaishvili, Maria Janikova, Michal Krupka
Publikováno v:
Oncotarget
Asporin has been reported as a tumor suppressor in breast cancer, while asporin-activated invasion has been described in gastric cancer. According to our in silico search, high asporin expresion associates with significantly better relapse free survi