Zobrazeno 61 - 70
of 141
pro vyhledávání: '"Afd Pharmacoepi & Clinical Pharmacology"'
Autor:
Vranken, Marjolein J.M., Linge-Dahl, Lisa, Mantel-Teeuwisse, Aukje K., Radbruch, Lukas, Schutjens, Marie Hélène DB, Scholten, Willem, Payne, Sheila, Jünger, Saskia, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Palliative Medicine, 34(4), 493. SAGE Publications Ltd
Background: In many countries, the consumption of opioid medicines is too low to meet population needs. Discussions within the Access To Opioid Medication in Europe project indicated that there may be significant differences in the perception of barr
Autor:
de Wilde, Sofieke, Coppens, Delphi G M, Hoekman, Jarno, de Bruin, Marie L, Leufkens, Hubert G M, Guchelaar, Henk-Jan, Meij, Pauline, Afd Pharmacoepi & Clinical Pharmacology, Innovation and Sustainability, Innovation Studies, Pharmacoepidemiology and Clinical Pharmacology, Chemical Biology and Drug Discovery
Publikováno v:
Drug Discovery Today, 23(7), 1328-1333
Drug Discovery Today, 23(7), 1328. Elsevier Ltd
Drug Discovery Today, 23(7), 1328. Elsevier Ltd
A comparative analysis of assessment procedures for authorization of all European Union (EU) applications for advanced therapy medicinal products (ATMPs) shows that negative opinions were associated with a lack of clinical efficacy and identified sev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ad504290ad4ddc54c929fc9b4db54c
https://hdl.handle.net/1887/75485
https://hdl.handle.net/1887/75485
Autor:
van Andel, Lotte, Rosing, Hilde, Schellens, Jan Hm, Beijnen, Jos H, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Marine Drugs
Marine Drugs, 16(7). Multidisciplinary Digital Publishing Institute (MDPI)
Marine Drugs, Vol 16, Iss 7, p 246 (2018)
Marine Drugs, 16(7). Multidisciplinary Digital Publishing Institute (MDPI)
Marine Drugs, Vol 16, Iss 7, p 246 (2018)
The discovery of marine-derived compounds for the treatment of cancer has seen a vast increase over the last few decades. Bioanalytical assays are pivotal for the quantification of drug levels in various matrices to construct pharmacokinetic profiles
Autor:
Gholizadeh, Shima, Dolman, Emmy M., Wieriks, Rebecca, Sparidans, Rolf W., Hennink, Wim E., Kok, Robbert J., Afd Pharmacoepi & Clinical Pharmacology, Afd Chemical Biology and Drug Discovery, Afd Pharmaceutics, Pharmacoepidemiology and Clinical Pharmacology, Pharmaceutics, Chemical Biology and Drug Discovery
Publikováno v:
Pharmaceutical Research, 35(4). Springer New York LLC
Pharmaceutical Research
Pharmaceutical Research
Purpose Sepantronium bromide (YM155) is a hydrophilic quaternary compound that cannot be administered orally due to its low oral bioavailability; it is furthermore rapidly eliminated via the kidneys. The current study aims at improving the pharmacoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebad93b68c0f15d59c10ac0bd77aa241
https://dspace.library.uu.nl/handle/1874/369779
https://dspace.library.uu.nl/handle/1874/369779
Autor:
Amstutz, Ursula, Henricks, Linda M, Offer, Steven M, Barbarino, Julia, Schellens, Jan H M, Swen, Jesse J., Klein, Teri E, McLeod, Howard L, Caudle, Kelly E, Diasio, Robert B, Schwab, Matthias, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Clinical Pharmacology and Therapeutics, 103(2), 210. Nature Publishing Group
Clinical Pharmacology and Therapeutics, 103(2), 210-216
Clinical Pharmacology and Therapeutics, 103(2), 210-216
Fluoropyrimidines (5-fluorouracil, capecitabine) are the mainstay chemotherapeutic agents for the treatment of many types of cancer. Metabolism of fluoropyrimidines requires dihydropyrimidine dehydrogenase (DPD encoded by the DPYD gene) and reduced o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2082150ddaf9a34a99367b5c46759968
https://hdl.handle.net/1887/74788
https://hdl.handle.net/1887/74788
Autor:
Subbiah, Vivek, Kreitman, Robert J, Wainberg, Zev A, Cho, Jae Yong, Schellens, Jan H M, Soria, Jean Charles, Wen, Patrick Y, Zielinski, Christoph, Cabanillas, Maria E, Urbanowitz, Gladys, Mookerjee, Bijoyesh, Wang, Dazhe, Rangwala, Fatima, Keam, Bhumsuk, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Journal of Clinical Oncology, 36(1), 7. American Society of Clinical Oncology
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol 36, iss 1
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, vol 36, iss 1
Purpose We report the efficacy and safety of dabrafenib (BRAF inhibitor) and trametinib (MEK inhibitor) combination therapy in BRAF V600E–mutated anaplastic thyroid cancer, a rare, aggressive, and highly lethal malignancy with poor patient outcomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e8886e5edaccc4d92f7b61a5b0ff37
https://dspace.library.uu.nl/handle/1874/362469
https://dspace.library.uu.nl/handle/1874/362469
Autor:
Keusters, W R, de Weger, Vincent A, Hövels, A, Schellens, J H M, Frederix, G W J, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Lung Cancer, 114, 56. Elsevier Ireland Ltd
Lung Cancer, 114, 56. Elsevier Ireland Ltd.
Lung Cancer, 114, 56. Elsevier Ireland Ltd.
Objectives The primary objective of this study was to identify the total intramural cost of illness of metastatic non-small cell lung cancer (NSCLC) in the Netherlands between 2006–2012. Secondary objective was to identify whether changes in cost p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e2e946ffb580512e8c094cf1672c3e
https://dspace.library.uu.nl/handle/1874/358424
https://dspace.library.uu.nl/handle/1874/358424
Autor:
Krul, Inge M, Opstal-van Winden, Annemieke W J, Aleman, Berthe M P, Janus, Cécile P M, van Eggermond, Anna M, De Bruin, Marie L, Hauptmann, Michael, Krol, Augustinus D G, Schaapveld, Michael, Broeks, Annegien, Kooijman, Karen R, Fase, Sandra, Lybeert, Marnix L, Zijlstra, Josée M, van der Maazen, Richard W M, Kesminiene, Ausrele, Diallo, Ibrahima, de Vathaire, Florent, Russell, Nicola S, van Leeuwen, Flora E, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
International Journal of Radiation Oncology-Biology-Physics, 99(4), 843-853
International Journal of Radiation Oncology, Biology, Physics, 99, 4, pp. 843-853
International Journal of Radiation Oncology, Biology, Physics, 99, 843-853
Krul, I M, Opstal-van Winden, A W J, Aleman, B M P, Janus, C P M, van Eggermond, A M, De Bruin, M L, Hauptmann, M, Krol, A D G, Schaapveld, M, Broeks, A, Kooijman, K R, Fase, S, Lybeert, M L, Zijlstra, J M, van der Maazen, R W M, Kesminiene, A, Diallo, I, de Vathaire, F, Russell, N S & van Leeuwen, F E 2017, ' Breast Cancer Risk After Radiation Therapy for Hodgkin Lymphoma : Influence of Gonadal Hormone Exposure ', International Journal of Radiation Oncology Biology Physics, vol. 99, no. 4, pp. 843-853 . https://doi.org/10.1016/j.ijrobp.2017.07.016
International Journal of Radiation Oncology Biology Physics, 99(4), 843-853. Elsevier Inc.
International journal of radiation oncology, biology, physics, 99(4), 843. Elsevier
International Journal of Radiation Oncology, Biology, Physics, 99, 4, pp. 843-853
International Journal of Radiation Oncology, Biology, Physics, 99, 843-853
Krul, I M, Opstal-van Winden, A W J, Aleman, B M P, Janus, C P M, van Eggermond, A M, De Bruin, M L, Hauptmann, M, Krol, A D G, Schaapveld, M, Broeks, A, Kooijman, K R, Fase, S, Lybeert, M L, Zijlstra, J M, van der Maazen, R W M, Kesminiene, A, Diallo, I, de Vathaire, F, Russell, N S & van Leeuwen, F E 2017, ' Breast Cancer Risk After Radiation Therapy for Hodgkin Lymphoma : Influence of Gonadal Hormone Exposure ', International Journal of Radiation Oncology Biology Physics, vol. 99, no. 4, pp. 843-853 . https://doi.org/10.1016/j.ijrobp.2017.07.016
International Journal of Radiation Oncology Biology Physics, 99(4), 843-853. Elsevier Inc.
International journal of radiation oncology, biology, physics, 99(4), 843. Elsevier
Item does not contain fulltext BACKGROUND: Young women treated with chest radiation therapy (RT) for Hodgkin lymphoma (HL) experience a strongly increased risk of breast cancer (BC). It is unknown whether endogenous and exogenous gonadal hormones aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e41e90cad74c87cd8212f407613cf9
http://hdl.handle.net/1887/115416
http://hdl.handle.net/1887/115416
Autor:
Hendrikx, Jeroen J M A, Haanen, John B.A.G., Voest, Emile E, Schellens, Jan H M, Huitema, Alwin D R, Beijnen, Jos H, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Oncologist, 22(10), 1212. AlphaMed Press
The Oncologist
The Oncologist
In the field of oncology, most drugs are administered in a body–size‐based dosing schedule instead of a fixed dose for all patients. This article presents the advantages of fixed dosing of monoclonal antibodies, arguing in favor of fixed dosing s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee96334e8722336eb868e434f5866d5f
https://dspace.library.uu.nl/handle/1874/361861
https://dspace.library.uu.nl/handle/1874/361861
Autor:
de Groot, Jolien S, van Diest, Paul J, van Amersfoort, Miranda, Vlug, Eva J, Pan, Xiaojuan, Ter Hoeve, Natalie D, Rosing, Hilde, Beijnen, Jos H, Youssef, Sameh A, de Bruin, Alain, Jonkers, Jos, van der Wall, Elsken, Derksen, Patrick W B, Regenerative Medicine, Stem Cells & Cancer, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology
Publikováno v:
Oncotarget, 8(37), 60750. Impact Journals LLC
Oncotarget, 8(37), 60750-60763. Impact Journals LLC
Oncotarget
Oncotarget, 8(37), 60750-60763. Impact Journals LLC
Oncotarget
// Jolien S. de Groot 1 , Paul J. van Diest 1 , Miranda van Amersfoort 1 , Eva J. Vlug 1 , Xiaojuan Pan 1 , Natalie D. ter Hoeve 1 , Hilde Rosing 2 , Jos H. Beijnen 2,3 , Sameh A. Youssef 4 , Alain de Bruin 4,5 , Jos Jonkers 6 , Elsken van der Wall 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e6bb8a0b97e4f428f007688baa3e72a
https://dspace.library.uu.nl/handle/1874/359866
https://dspace.library.uu.nl/handle/1874/359866