Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tomi P. Mäkelä"'
Autor:
Yan Yan, Tea Vallenius, Tomi P. Mäkelä, Iris P. L. Wong, Jorma J. Palvimo, Kari Vaahtomeri, Saara Ollila
Publikováno v:
Nature Communications
Article
AMP-activated protein kinase (AMPK) inhibits several anabolic pathways such as fatty acid and protein synthesis, and identification of AMPK substrate specificity would be useful to understand its role in particular cellular processes and
AMP-activated protein kinase (AMPK) inhibits several anabolic pathways such as fatty acid and protein synthesis, and identification of AMPK substrate specificity would be useful to understand its role in particular cellular processes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66609806e6560b215a785df5efc6527b
http://hdl.handle.net/10138/165272
http://hdl.handle.net/10138/165272
Autor:
Niklas Ekman, Marianne Tiainen, Tea Vallenius, Pekka Katajisto, Tomi P. Mäkelä, Kari Vaahtomeri, Anou Londesborough
Publikováno v:
Development. 135:2331-2338
Inactivation of the tumor suppressor kinase Lkb1 in mice leads to vascular defects and midgestational lethality at embryonic day 9-11 (E9-E11). Here, we have used conditional targeting to investigate the defects underlying the Lkb1(-/-) phenotype. En
Autor:
Tea Vallenius, Lina Udd, Kari Vaahtomeri, Tomi P. Mäkelä, Marianne Tiainen, Pekka Katajisto, Niklas Ekman
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1775:63-75
Inactivating germline mutations in the LKB1 gene underlie Peutz-Jeghers syndrome characterized by hamartomatous polyps and an elevated risk for cancer. Recent studies suggest the involvement of LKB1 also in more common human disorders including diabe
Autor:
Lauri A. Aaltonen, Virpi Launonen, Keijo Luukko, Nina Korsisaari, Tomi P. Mäkelä, Ari Ristimäki, Antti Ylikorkala, Mark Henkemeyer, Derrick J. Rossi, Reijo Salovaara
Publikováno v:
Proceedings of the National Academy of Sciences. 99:12327-12332
Inactivating germ-line mutations of LKB1 lead to Peutz–Jeghers syndrome (PJS). We have generated mice heterozygous for a targeted inactivating allele of Lkb1 and found that they develop severe gastrointestinal polyposis. In all cases, the polyps ar
Autor:
Derrick J. Rossi, Kari Alitalo, Antti Ylikorkala, Nina Korsisaari, Keijo Luukko, Tomi P. Mäkelä, Mark Henkemeyer
Publikováno v:
Science. 293:1323-1326
The LKB1 tumor suppressor gene, mutated in Peutz-Jeghers syndrome, encodes a serine/threonine kinase of unknown function. Here we show that mice with a targeted disruption of Lkb1 die at midgestation, with the embryos showing neural tube defects, mes
Autor:
Tomi P. Mäkelä, Saara Ollila
Publikováno v:
Journal of molecular cell biology. 3(6)
Mutations in the tumor suppressor gene LKB1 are important in hereditary Peutz-Jeghers syndrome, as well as in sporadic cancers including lung and cervical cancer. LKB1 is a kinase-activating kinase, and a number of LKB1-dependent phosphorylation casc
Autor:
Arja M. Band, Mia A. Björklund, Tomi P. Mäkelä, Marikki Laiho, Kari Vaahtomeri, Karita Peltonen, Benoit Viollet
Publikováno v:
Experimental cell research. 316(5)
p27Kip1 (p27) tumour suppressor protein is regulated by multiple mechanisms including its turnover, localization and complex formation with its key targets, cyclin-dependent kinases (CDK) and cyclins. We have earlier shown that p27 exists in cells in
Publikováno v:
The EMBO journal. 8(1)
We have examined post-translational modification of the L-myc protein using polyclonal and monoclonal antibodies against a peptide well conserved in the predicted amino acid sequences of the c-myc, N-myc and L-myc genes. These antibodies precipitate