Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Tomi P. Mäkelä"'
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0196986 (2018)
PLoS ONE, Vol 13, Iss 5, p e0196986 (2018)
The controlled formation and stabilization of E-cadherin-based adhesions is vital for epithelial integrity. This requires co-operation between the E-cadherin-based adhesions and the associated actin cytoskeleton. In cancer, this co-operation often fa
Autor:
Tomi P. Mäkelä, M Sandberg, Sakari Knuutila, Juha Partanen, K Huebner, Elina Armstrong, Jaana Korhonen, Risto Renkonen, Kari Alitalo
Publikováno v:
Molecular and Cellular Biology. 12:1698-1707
Endothelial cell surfaces play key roles in several important physiological and pathological processes such as blood clotting, angiogenic responses, and inflammation. Here we describe the cloning and characterization of tie, a novel type of human end
Publikováno v:
Europe PubMed Central
Chromosomal abnormalities affecting proto-oncogenes are frequently detected in human cancer. Oncogenes of the myc family are activated in several types of tumors as a result of gene amplification or chromosomal translocation. We have recently found t
Autor:
Juha Partanen, Kari Alitalo, Elina Eerola, Lena Claesson-Welsh, Jaana Korhonen, H. Hirvonen, Tomi P. Mäkelä
Publikováno v:
The EMBO Journal. 10:1347-1354
We have previously identified two novel members of the fibroblast growth factor receptor (FGFR) gene family expressed in K562 erythroleukemia cells. Here we report cDNA cloning and analysis of one of these genes, named FGFR-4. The deduced amino acid
Publikováno v:
Proceedings of the National Academy of Sciences. 87:8913-8917
Tyrosine phosphorylation is important in the transmission of growth and differentiation signals; known tyrosine kinases include several oncoproteins and growth factor receptors. Interestingly, some differentiated cell types, such as erythrocytes and
Two N-myc polypeptides with distinct amino termini encoded by the second and third exons of the gene
Publikováno v:
Molecular and Cellular Biology. 9:1545-1552
The N-myc and c-myc genes encode closely related nuclear phosphoproteins. We found that the N-myc protein from human tumor cell lines appears as four closely migrating polypeptide bands (p58 to p64) in sodium dodecyl sulfate-polyacrylamide gels. This
Publikováno v:
The EMBO journal. 8(1)
We have examined post-translational modification of the L-myc protein using polyclonal and monoclonal antibodies against a peptide well conserved in the predicted amino acid sequences of the c-myc, N-myc and L-myc genes. These antibodies precipitate
Publikováno v:
ResearcherID
University of Helsinki
University of Helsinki
Oncogenic activation of myc genes in human cancer involves deregulated expression of myc proteins with no major structural alterations. Here two independent small cell lung carcinoma (SCLC) cell lines were found to express similar novel proteins anti
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