Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tomi P. Mäkelä"'
Publikováno v:
EMBO reports. 14:741-747
Loss of primary cilia is frequently observed in tumour cells, including glioblastoma cells, and proposed to benefit tumour growth, but a causal link has not been established. Here, we show that CCRK (cell cycle-related kinase) and its substrate ICK (
Autor:
Yan Yan, Tea Vallenius, Tomi P. Mäkelä, Iris P. L. Wong, Jorma J. Palvimo, Kari Vaahtomeri, Saara Ollila
Publikováno v:
Nature Communications
Article
AMP-activated protein kinase (AMPK) inhibits several anabolic pathways such as fatty acid and protein synthesis, and identification of AMPK substrate specificity would be useful to understand its role in particular cellular processes and
AMP-activated protein kinase (AMPK) inhibits several anabolic pathways such as fatty acid and protein synthesis, and identification of AMPK substrate specificity would be useful to understand its role in particular cellular processes and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66609806e6560b215a785df5efc6527b
http://hdl.handle.net/10138/165272
http://hdl.handle.net/10138/165272
Publikováno v:
Molecular and Cellular Biology. 29:315-323
Mammalian Cdk7, cyclin H, and Mat1 form the kinase submodule of transcription factor IIH (TFIIH) and have been considered ubiquitously expressed elements of the transcriptional machinery. Here we found that Mat1 and Cdk7 levels are undetectable in ad
Autor:
Tomi P. Mäkelä, Nina Korsisaari
Publikováno v:
Journal of Biological Chemistry. 275:34837-34840
Cyclin-dependent kinase 7 (Cdk7) forms a trimeric complex with cyclin H and Mat1 to form the mammalian Cdk-activating kinase, CAK, as well as a part of the basal transcription factor TFIIH, where Cdk7 phosphorylates the C-terminal domain (CTD) of the
Publikováno v:
Biochemical and Biophysical Research Communications. 247:616-619
The natural estrogen metabolite 2-methoxyestradiol (2ME) is anti-angiogenic in vivo and a strong growth inhibitor in vitro. The growth inhibition is due to mitotic arrest and apoptosis. These effects are reminiscent of those induced by taxol, and app
Autor:
Ana-Maria Osiceanu, Tea Vallenius, Tomi P. Mäkelä, Martta Leena Maria Viljanen, Kari Vaahtomeri, Bianca Kovac
Publikováno v:
Journal of cell science. 124(Pt 3)
Actin stress fiber assembly and contractility in nonmuscle motile cells requires phosphorylation of myosin regulatory light chain (MLC). Dephosphorylation and disassembly are mediated by MLC phosphatase, which is targeted to actin fibers by the assoc
Autor:
Päivi M. Ojala, Tomi P. Mäkelä, Kazuhito Yamamoto, Stanley J. Korsmeyer, Peter Biberfeld, Esmeralda Castaños-Velez
Publikováno v:
Nature cell biology. 2(11)
v-cyclin encoded by Kaposi's sarcoma herpesvirus/human herpesvirus 8 (KSHV or HHV8) associates with cellular cyclin-dependent kinase 6 (CDK6) to form a kinase complex that promotes cell-cycle progression, but can also induce apoptosis in cells with h
Autor:
René H. Medema, Tea Vallenius, Veronique A. J. Smits, Gert Rijksen, Rob Klompmaker, Tomi P. Mäkelä
Publikováno v:
Journal of biological chemistry, 275(39), 30638. American society for biochemistry and molecular biology
The cyclin-dependent kinase inhibitor p21 is required for a sustained G(2) arrest after activation of the DNA damage checkpoint. Here we have addressed the mechanism by which p21 can contribute to this arrest in G(2). We show that p21 blocks the acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad10fb5f40be457c6ee4dd2b8031d50c
https://dspace.library.uu.nl/handle/1874/7907
https://dspace.library.uu.nl/handle/1874/7907
Autor:
D. Grahame Hardie, Jennifer L Reid, Simon A. Hawley, Dario R. Alessi, Jérôme Boudeau, Tomi P. Mäkelä, Lina Udd, Kirsty J. Mustard
Publikováno v:
Journal of Biology. 2:28
The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy charge that acts as a 'metabolic master switch' and inhibits cell proliferation. Activation requires phosphorylation of Thr172 of AMPK within the activation loop by upstre
Publikováno v:
The EMBO journal. 8(1)
We have examined post-translational modification of the L-myc protein using polyclonal and monoclonal antibodies against a peptide well conserved in the predicted amino acid sequences of the c-myc, N-myc and L-myc genes. These antibodies precipitate