Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Vincent W. Keng"'
Autor:
Eunice Y. Lau, Man Tong, Katherine Po Sin Chung, Terence K. Lee, Stephanie Ma, Rainbow Wing Hei Leung, Etienne H. Mok, Irene Oi-Lin Ng, Martina Mang Leng Lei, Q Zhao, Vincent W. Keng, Carmen Oi Ning Leung, Hoi Wing Leung, Cong Ma
Publikováno v:
Cancer Research. 81:3229-3240
The survival benefit derived from sorafenib treatment for patients with hepatocellular carcinoma (HCC) is modest due to acquired resistance. Targeting cancer stem cells (CSC) is a possible way to reverse drug resistance, however, inhibitors that spec
Publikováno v:
Biochemical and Biophysical Research Communications. 541:70-77
A forward genetic Sleeping Beauty (SB) insertional mutagenesis screen, followed by high-throughput transcriptome sequencing, was used to identify driver genes responsible for hepatocellular carcinoma (HCC)-associated metastasis. Using RNA-sequencing
Autor:
Lilian H. Lo, Shi Jie Zhang, David A. Largaespada, Xiao Xiao Li, Xin Yi Lu, Vincent W. Keng, Qu Bo Chen, Amy P. Chiu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 111, Iss, Pp 68-75 (2019)
Non-alcoholic fatty liver disease (NAFLD) is becoming an epidemic disease in adults and children worldwide. Importantly, there are currently no approved treatments available for NAFLD. This study aims to investigate the potential applications of sodi
Autor:
Xiao-Xiao Li, Jian Huang, Dewi Kenneth Rowlands, Shi Jie Zhang, Lilian H. Lo, Amy P. Chiu, Vincent W. Keng, Jinhui Wang
Publikováno v:
Cancer Medicine. 7:4791-4800
Malignant peripheral nerve sheath tumors (MPNSTs) are an aggressive form of soft tissue neoplasm with extremely poor prognosis and no effective medical options currently available. MPNSTs can occur either sporadically or in association with the neuro
Autor:
David A. Largaespada, Roser Pinyol, Bryant J. Keller, Barbara R. Tschida, Nuri A. Temiz, Helena Cornella, Timothy P. Kuka, Juan E. Abrahante, Michael A. Linden, Nicholas Koes, Khalid Amin, Gabriel Kaufmann, Germán L. Vélez-Reyes, Caitlin B. Conboy, Josep M. Llovet, Hsiangyu Hu, Vincent W. Keng, Clara Alsinet, Timothy K. Starr
Publikováno v:
Hepatology Communications
Hepatology Communications, Vol 3, Iss 11, Pp 1496-1509 (2019)
Hepatology Communications, Vol 3, Iss 11, Pp 1496-1509 (2019)
Each year, more than 25,000 people succumb to liver cancer in the United States, and this neoplasm represents the second cause of cancer‐related death globally. R‐spondins (RSPOs) are secreted regulators of Wnt signaling that function in developm
Autor:
Amy P. Chiu, Vincent W. Keng
Publikováno v:
Methods in Molecular Biology ISBN: 9781493989669
Understanding the complex genetic background of cancers is key in developing effective targeted therapies. The Sleeping Beauty (SB) transposon system is a powerful and unbiased genetic editing tool that can be used for rapid screening of candidate li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d62b43d243d2ac1f6904fb7796aadb6
https://doi.org/10.1007/978-1-4939-8967-6_15
https://doi.org/10.1007/978-1-4939-8967-6_15
Autor:
Barbara R. Tschida, Vincent W. Keng, Margaret H. Collins, David A. Largaespada, Hua Li, Adrienne L. Watson, Tilat A. Rizvi, Kwangmin Choi, Branden S. Moriarity, Margaret R. Wallace, Eric P. Rahrmann, Nancy Ratner
Publikováno v:
Sarcoma
Sarcoma, Vol 2012 (2012)
Sarcoma, Vol 2012 (2012)
The genetic mechanisms involved in the transformation from a benign neurofibroma to a malignant sarcoma in patients with neurofibromatosis-type-1- (NF1-)associated or sporadic malignant peripheral nerve sheath tumors (MPNSTs) remain unclear. It is hy
Autor:
David A. Largaespada, Manel Solé, Kevin A. T. Silverstein, Branden S. Moriarity, Danhua Fan, Timothy P. Kuka, Augusto Villanueva, Jason B. Bell, Aaron L. Sarver, Adam J. Dupuy, Wai L. Lee, Jesse D. Riordan, Barbara R. Tschida, Clara Alsinet, Josep M. Llovet, Daniela Sia, Vincent W. Keng
Hepatocellular carcinoma (HCC) is one of the deadliest solid cancers and is the third leading cause of cancer-related death. There is a universal estimated male/female ratio of 2.5, but the reason for this is not well understood. The Sleeping Beauty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16449023f957a44d7127de5bb72cd1c9
https://europepmc.org/articles/PMC3511635/
https://europepmc.org/articles/PMC3511635/