Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Jaeho Jung"'
Autor:
Seung-Woo Lee, Shinai Lee, Wonjun Son, Eunyoung Park, Yunji Park, Park Kyeongsu, Sora Kim, Ji-Hae Kim, Yeon-Woo Kang, Yangsoon Lee, Jonghwa Won, Han Wook Park, Yong-Gyu Son, Jung Uijung, Young-Min Kim, Dain Moon, Gihoon You, Hyekang Kim, Eom Jaehyun, Chung Hyejin, Jaeho Jung
Publikováno v:
Science Advances. 7
Cancer immunotherapy with 4-1BB agonists has limited further clinical development because of dose-limiting toxicity. Here, we developed a bispecific antibody (bsAb; B7-H3×4-1BB), targeting human B7-H3 (hB7-H3) and mouse or human 4-1BB, to restrict t
Autor:
Minwoo Jeon, Han-Byul Lee, Seongju Jeong, Shin Hwang, Hyung-Don Kim, Zhengyi Wang, Hyunjoo Kim, Su-Hyung Park, Eun-Sil Sung, Jung Uijung, Jeon Jaehyoung, Eui-Cheol Shin, Yangmi Lim, Shinai Lee, Jiang Wenqing, Kim Youngkwang, Eunyoung Park, Youngeun Hong, Fang Lei, Son Yonggyu, Jonghwa Won, Jaeho Jung
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundStimulation of 4-1BB with agonistic antibodies is a promising strategy for improving the therapeutic efficacy of immune checkpoint inhibitors (ICIs) or for overcoming resistance to ICIs. However, dose-dependent hepatotoxicity was observed i