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Publikováno v:
BMJ Case Rep
We report a case of periocular squamous cell carcinoma invading the anterior orbit that significantly reduced in size and regressed from invasive to in situ following treatment with oral acitretin, a second-generation retinoid. The residual in situ d
Autor:
Bianca de Oliveira Alves, Mikaela Scatolin, João G.G. Guzatti, Jacir Dal Magro, Jean Felipe Fossá Calisto, J. Vladimir Oliveira, Rafael Martello, Letícia V. Morgan, Maryelen A. Souza, Monica S.Z. Schindler, Liz Girardi Müller, Jaqueline Scapinello
Publikováno v:
Biomedical Journal. 44:S63-S72
Background A. gratissima is a shrub used in folk medicine as analgesic and sedative. However, studies on its antinociceptive activity are scarce. This research aimed to evaluate the antinociceptive effect of a supercritical carbon dioxide (SCCO2) ext
Autor:
Johanna Lilja, Ella-Maria Vesilahti, Johanna M. Anttila, Hussein Al-Akhrass, Johanna Ivaska, Emilia Peuhu, Pauliina Munne, Mika Pietilä, Juha Klefström, Heidi M. Haikala
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 16, Iss 1, Pp 116-129 (2022)
Molecular Oncology, Vol 16, Iss 1, Pp 116-129 (2022)
In breast cancer, the currently approved anti‐receptor tyrosine‐protein kinase erbB‐2 (HER2) therapies do not fully meet the expected clinical goals due to therapy resistance. Identifying alternative HER2‐related therapeutic targets could off
Autor:
Kazuharu Kai, Krina K. Patel, Lihua E. Budde, Hayder Saeed, Cameron J. Turtle, Nina Shah, Alan Tan, Andrew J. Cowan, Jonathan Zalevsky, Mitchell S. Cairo, Zachary J. Lee, Mary Tagliaferri, Mario Q. Marcondes, Miguel-Angel Perales
Publikováno v:
Future Oncology. 17:3549-3560
NKTR-255 is an investigational polyethylene glycol-modified recombinant human IL-15 (rhIL-15) receptor agonist, designed to improve the immunotherapeutic and anti-cancer benefit observed with rhIL-15 while circumventing the toxicities associated with
Autor:
Yangming Zhang, Xiao-Li Wei, Zhiwei Gao, Hu Xiaobei, Yifan Zhang, Xiaofeng Han, Jia Li, Li Sheng, Song-da Yu, Honghui Huang, Lijing Shen, Yue Zhang, Fajun Nan, Anhui Gao, Yubo Zhou, Xiaoyan Chen, Jian Hou, Mingbo Su
Publikováno v:
Acta Pharmacologica Sinica. 43:1091-1099
HDAC inhibitors (HDACis) have been intensively studied for their roles and potential as drug targets in T-cell lymphomas and other hematologic malignancies. Bisthianostat is a novel bisthiazole-based pan-HDACi evolved from natural HDACi largazole. He
Autor:
Seyed Mohammadreza Hashemian, Ahmad Reza Dehpour, Hasan Yousefi-Manesh, Majid Sorouri, Moein Ala, Sevda Shayesteh, Amir Rashidian, Razieh Mohammad Jafari
Publikováno v:
Archives of Medical Research. 52:595-602
Background Crohn's disease (CD), a type of inflammatory bowel disease (IBD), emerges with severe gastrointestinal (GI) tract inflammation, sometimes known as hostile abdomen. Conventional treatment of CD has several limitations such as insufficient r
Autor:
Silvia Olivari, Gary Binder, Erminio Bonizzoni, Eric Roeland, Rudolph M. Navari, Rebecca Clark-Snow
Publikováno v:
Future Oncology. 17:3027-3035
Aim: In the absence of comparative studies, guidelines consider neurokinin 1 receptor antagonists (RAs) as interchangeable. We evaluated the pooled efficacy from three cisplatin registration trials, each with arms containing netupitant/palonosetron (
Autor:
Julie A. Price Hiller, Nancy A. Nixon, Anil A. Joy, Bassam Basulaiman, John Hilton, Terry L. Ng, Mohammed F.K. Ibrahim, Dean Fergusson, Marta Sienkiewicz, Arif Awan, Brian Hutton, Mark Clemons, Lisa Vandermeer, John R. Mackey, Deanna Saunders, Xiaofu Zhu, Gregory R. Pond, Judith Meza-Junco, Lacey D. Pitre, Kednapa Thavorn
Publikováno v:
The Breast : Official Journal of the European Society of Mastology
Breast, Vol 58, Iss, Pp 42-49 (2021)
Breast, Vol 58, Iss, Pp 42-49 (2021)
Background Primary febrile neutropenia (FN) prophylaxis with ciprofloxacin or granulocyte-colony stimulating factors (G-CSF) is recommended with docetaxel-cyclophosphamide (TC) chemotherapy for early-stage breast cancer (EBC). A pragmatic randomised
Publikováno v:
Investigación Clínica. 62:69-84
Las tetraciclinas se han utilizado para tratar muchas infecciones bacterianas. El uso de estos antibióticos para el tratamiento de enfermedades virales se remonta a las décadas de 1960 y 1970. Estudios posteriores han demostrado la eficacia de las
Publikováno v:
Journal of Pediatric Surgery. 56:1145-1149
Objective: Through historical comparison with our previous study published 10 years ago, this paper aims to provide latest analysis of local bacteriology of acute complicated appendicitis and evaluate the effects of early escalation of potent antibio