Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Preclinical research"'
Autor:
Xizhe Wang, N. Patrik Brodin, Maria Maryanovich, Kara L. Watts, Ali H. Zahalka, Chandan Guha, Sandra Pinho, Paul S. Frenette
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
Scientific Reports
Scientific Reports
The prostate is a hormone-responsive organ where testicular androgens drive the proliferation and survival of prostatic cells, ensuring the development and functioning of this gland throughout life. Androgen deprivation therapy leads to apoptosis of
Autor:
Watcharamat Muangkaew, Kanchana Kengkoom, Passanesh Sukphopetch, Sumate Ampawong, Tapanee Kanjanapruthipong, Theerapong Buaban, Pornanong Aramwit
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Psoriasis is mainly caused because of inappropriate immune responses in the epidermis. Rice (Oryza sativa L.: SRNC05053-6-2) consists of anthocyanin, which exhibits strong antioxidative and anti-inflammatory properties. This study aimed to evaluate t
Autor:
Youn-Ho Lee, Jina Oh, Young-Joon Lee, Sae-Kwang Ku, Phil Hyun Song, Choong-Gon Kim, Dae-Geon Lee, Chang-Hyun Song
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Balneotherapy is a common non-pharmacological treatment for osteoarthritis (OA), however, the efficacy is controversial in knee OA. Jeju magma-seawater (JMS) has high contents of various minerals, which has anti-inflammatory and antioxidant propertie
Autor:
Vanessa Almonte, Dario F. Riascos-Bernal, Lander Egaña-Gorroño, Smitha Jayakumar, Nicholas E.S. Sibinga, Dippal Parikh, Prameladevi Chinnasamy
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
The allograft inflammatory factor (AIF) gene family consists of two identified paralogs – AIF1 and AIF1-like (AIF1L). The encoded proteins, AIF1 and AIF1L, are 80% similar in sequence and show conserved tertiary structure. While studies in human po
Autor:
Jorge E. Lopera, Sang Hyun Shin, Nader Bakheet, Chang Mo Hwang, Sarang Hong, Song Cheol Kim, Jae Yong Jeon, Ho Young Song, Jung-Hoon Park, Yejong Park, In Kyong Shim
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Stricture of pancreatic-enteric anastomoses is a major late complication of a pancreaticoduodenectomy for the treatment of a periampullary tumor and can lead to exocrine and endocrine insufficiency such as malnutrition and diabetes mellitus. We inves
Autor:
Raymond Pieters, Klaus Gjervig Jensen, Philip G. Hewitt, Jan Snoeys, Bob van de Water, B. Kevin Park, Ursula Klingmüller, André Guillouzo, Ian M. Copple, Dominic P. Williams, Michael J. Liguori, Cerys A. Lovatt, Paul Morgan, Satu Juhila, Eric A.G. Blomme, Magnus Ingelman-Sundberg, Dean J. Naisbitt, Gilles Labbe, Amy E. Chadwick, Christopher E. Goldring, Helga H.J. Gerets, Richard J. Weaver
Publikováno v:
Nature Reviews Drug Discovery
Nature Reviews Drug Discovery, 2020, 19 (2), pp.131-148. ⟨10.1038/s41573-019-0048-x⟩
Nature Reviews Drug Discovery, Nature Publishing Group, 2020, 19 (2), pp.131-148. ⟨10.1038/s41573-019-0048-x⟩
NATURE REVIEWS DRUG DISCOVERY
Nature Reviews Drug Discovery, 19, 131-148
Nature Reviews Drug Discovery, 2020, 19 (2), pp.131-148. ⟨10.1038/s41573-019-0048-x⟩
Nature Reviews Drug Discovery, Nature Publishing Group, 2020, 19 (2), pp.131-148. ⟨10.1038/s41573-019-0048-x⟩
NATURE REVIEWS DRUG DISCOVERY
Nature Reviews Drug Discovery, 19, 131-148
International audience; Drug-induced liver injury (DILI) is a patient-specific, temporal, multifactorial pathophysiological process that cannot yet be recapitulated in a single in vitro model. Current preclinical testing regimes for the detection of
Autor:
Sang Hoon Ahn, Gregor Ebert, Shringar Rao, Vitina Sozzi, Margaret Littlejohn, Bang M Tran, L. Earnest, Peter Revill, Michelle P. Clark, Marc Pellegrini, Thao Huynh, Tokameh Mahmoudi, Liana Mackiewicz, Shahla Romal, Joseph Torresi, Norbert Wiedemann, Hans J Netter, Elizabeth Vincan, Hugh Mason, Michael D. Stutz
Publikováno v:
Cell Death and Disease, Vol 12, Iss 7, Pp 1-11 (2021)
Cell Death & Disease
Cell Death and Disease, 12(7):641. Nature Publishing Group
Cell Death & Disease
Cell Death and Disease, 12(7):641. Nature Publishing Group
A major unmet clinical need is a therapeutic capable of removing hepatitis B virus (HBV) genome from the liver of infected individuals to reduce their risk of developing liver cancer. A strategy to deliver such a therapy could utilize the ability to
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
For research on tendon injury, many different animal models are utilized; however, the extent to which these species simulate the clinical condition and disease pathophysiology has not yet been critically evaluated. Considering the importance of infl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e56c20d61f0138d3f8943c46d6dcb5
https://doi.org/10.1101/2021.05.09.443263
https://doi.org/10.1101/2021.05.09.443263
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Cell Death and Disease, Vol 12, Iss 4, Pp 1-15 (2021)
Chemotherapeutic agents have been linked to immunogenic cell death (ICD) induction that is capable of augmenting anti-tumor immune surveillance. The cardiac glycoside oleandrin, which inhibits Na+/K+-ATPase pump (NKP), has been shown to suppress brea
Publikováno v:
Clinical & Experimental Metastasis. 35:715-725
Metastasis is key to cancer mortality. Understanding its biology is vital for developing strategies to prevent and treat metastasis. Phenotypic assays to either study metastasis or evaluate anti-metastatic drugs are widely used in preclinical researc