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Autor:
Johanna Vappiani, Terezinha de Souza, Theo M. de Kok, Luke Coyle, Julio Saez-Rodriguez, Danyel Jennen, Daniel C. Sévin, D. F. Rodrigues, Seung-Wook Chung, Matteo Di Piazza, Bram Herpers, Attila Gábor, Mian Zhang, Anthony M. Lynch, Jos C. S. Kleinjans, Sofia Ferreira
Publikováno v:
Archives of Toxicology
Archives of Toxicology, 95(8), 2691-2718. Springer
Archives of Toxicology, 95(8), 2691-2718. Springer
5-Fluorouracil (5-FU) is a widely used chemotherapeutical that induces acute toxicity in the small and large intestine of patients. Symptoms can be severe and lead to the interruption of cancer treatments. However, there is limited understanding of t
Publikováno v:
DNA and Cell Biology. 40:1112-1123
Dysfunction of bone marrow mesenchymal stem cells (BMSCs) is recognized critical in bone deteriorations of osteoporosis. However, the specific mechanisms that determine the fate of BMSCs remain elusive. MicroRNA-133a (miR-133a), a highly conserved mi
Publikováno v:
Virchows Archiv
Merkel cell carcinoma (MCC) is a rare and aggressive neuroendocrine malignancy of the skin. The cell of origin of MCC is thus far unknown and proposed cells of origin include Merkel cells, pro-/pre- or pre-B cells, epithelial stem cells, and dermal s
Autor:
Yih Giun Cherng, Oluwaseun Adebayo Bamodu, Shiue Wei Lai, Ming Yao Chen, Chi Tai Yeh, Ming Shou Hsieh, Ting Yi Huang, Wei Hwa Lee
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Background. Treating advanced colon cancer remains challenging in clinical settings because of the development of drug resistance and distant metastasis. Mechanisms underlying the metastasis of colon cancer are complex and unclear. Methods. Computati
Publikováno v:
Biol Reprod
As a potent autocrine regulator, the proinflammatory cytokine interleukin 6 (IL6) is expressed in granulosa cells and is involved in the modulation of various follicular functions, including follicular development and ovulation. At present, the detai
Autor:
Tamar Schlick
Publikováno v:
DNA Cell Biol
The life and work of crystallography pioneer Isabella L. Karle is recounted (1921–2017), as researched from the literature and personal stories of colleagues and family. Her story includes her family background, education at the University of Michi
Autor:
Parisa Aziminezhadan, Zohreh Abdolvahabi, Shahin Alizadeh-Fanalou, Masoumeh Tavakoli-Yaraki, Saman Hosseinkhani, Mitra Nourbakhsh, Meysam Abolmaali, Samira Ezzati-Mobaser, Zahra Hesari, Ali Nazarizadeh
Publikováno v:
DNA and Cell Biology. 40:1026-1036
NAD is mainly biosynthesized by the enzymatic action of nicotinamide phosphoribosyltransferase (NAMPT) through the salvage pathway. NAD is indispensable for the proper function and metabolism of all living cells, including cancer cells. Our previous
Publikováno v:
Molecular and Cellular Biochemistry. 476:3951-3962
MicroRNA (miR)-17-5p has been investigated in many diseases as a regulator of disease progression and is highly expressed in acute myeloid leukemia (AML). However, potential mechanisms underlying the function of miR-17-5p in AML need more elucidation
Autor:
Aleksandra Klisic, Svetozar Putnik, Natasa Bogavac-Stanojevic, Luka Babic, Milos Matkovic, Vojislava Neskovic, Aleksandar Mikic, Petar Vukicevic, Nemanja Aleksic, Jelena Kotur-Stevuljevic
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Objective. Recent studies have shown that the red cell distribution width- (RDW-) to-platelet (PLT) count ratio (i.e., RPR) and the mean platelet volume (MPV)/PLT ratio (i.e. MPR) are more sensitive markers of atherosclerosis-connected risk than RDW
Publikováno v:
Journal of Molecular Histology
Necroptosis is a novel manner of programmed cell death and important for tissue development, homeostasis, damage, and repair. Activation of receptor-interacting protein kinase 3 (RIPK3), a key member of receptor-interacting protein family in contribu