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Publikováno v:
Genes & Diseases. 9:705-716
The deltex family protein DTX3 is believed to possess E3 ubiquitin ligase activity, as it contains a classic RING finger domain. However, its biological role and the underlying mechanism in cancer remain largely elusive. Here, we identified DTX3 as a
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 37:246-255
Background: Pituitary adenoma (PA) is a kind of common primary brain tumor with invasive properties. Although the fact that long noncoding RNA (lncRNA) small nucleolar RNA host gene 6 (SNHG6) exerts oncogenic function in cancer cells and that miR-944
Publikováno v:
Seminars in Cancer Biology. 80:145-156
Mushrooms, both edible and medicinal have received considerable attention against cancer due to their polysaccharides, polysaccharides-protein complexes and low molecular weight secondary metabolites content. Every year, millions of people die becaus
Publikováno v:
Seminars in Cancer Biology. 80:58-72
The recent advances in cancer immunotherapy confirm the crucial role of the immune system in cancer progression and treatment. Chronic inflammation and reduced immune surveillance are both features of the tumor microenvironment. Strategies aimed at r
Autor:
Cornelia Braicu, Ioana Berindan-Neagoe, Alina-Andreea Zimta, Oana Zanoaga, Anupam Bishayee, Kaitlyn L. Kilpatrick, Adrian Bogdan Tigu, Seyed Mohammad Nabavi
Publikováno v:
Seminars in Cancer Biology. 80:218-236
Due to the high number of annual cancer-related deaths, and the economic burden that this malignancy affects today's society, the study of compounds isolated from natural sources should be encouraged. Most cancers are the result of a combined effect
Autor:
Prakash Baligar, Jayanta K. Pal, Manoj Garg, Eiji Yuba, Gautam Sethi, Amit Awasthi, Vaishnavi U Warrier, Anuradha Kirtonia, Daizy Sadaria, Ravi Kant, Bhavika Gupta, Rajesh Kumar Gupta
Publikováno v:
Seminars in Cancer Biology. 80:87-106
Plant lectins, a natural source of glycans with a therapeutic potential may lead to the discovery of new targeted therapies. Glycans extracted from plant lectins are known to act as ligands for C-type lectin receptors (CLRs) that are primarily presen
Autor:
Ekene Emmanuel Nweke, Pascaline Fru, Nompumelelo Mthimkhulu, Mohammed Balogun, Karabo S. Mosiane
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1699-1713
Abstract: Synthetic chemotherapeutics have played a crucial role in minimizing mostly palliative symptoms associated with cancer; however, they have also created other problems such as system toxicity due to a lack of specificity. This has led to the
Autor:
Soumya Ranjan Mishra, Chandra Sekhar Bhol, Sujit K. Bhutia, Samir Kumar Patra, Bishnu Prasad Behera, Srimanta Patra, Gautam Sethi, Prakash Priyadarshi Praharaj, Debasna P. Panigrahi, Kewal Kumar Mahapatra
Publikováno v:
Seminars in Cancer Biology. 80:205-217
Autophagy is an intracellular catabolic self-cannibalism that eliminates dysfunctional cytoplasmic cargos by the fusion of cargo-containing autophagosomes with lysosomes to maintain cyto-homeostasis. Autophagy sustains a dynamic interlink between cyt
Publikováno v:
Seminars in Cancer Biology. 80:276-305
Several signaling pathways and basic metabolites are responsible for the control of metabolism in both normal and cancer cells. As emerging hallmarks of cancer metabolism, the abnormal activities of these pathways are of the most noticeable events in
Autor:
Michael B. Livingston, Anthony D. Elias, Tony Philip, Michael Chen, Margaret von Mehren, Sant P. Chawla, Scott H. Okuno, Sergey Yurasov, Brian A. Van Tine, Claire F. Verschraegen, Robert G. Maki, Steven Attia, G Chet Bohac, Kristen N. Ganjoo, Hailing Lu, Richard F. Riedel, Mark Agulnik, Edwin Choy, Vicki L. Keedy, Adam Yakovich, Seth M. Pollack
Publikováno v:
Journal of Clinical Oncology. 40:1291-1300
PURPOSE CMB305 is a heterologous prime-boost vaccination regimen created to prime NY-ESO-1–specific CD8 T-cell populations and then activate the immune response with a potent TLR-4 agonist. This open-label randomized phase II trial was designed to