Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Robert Somerville"'
Autor:
Harshini Chinnasamy, Todd D. Prickett, Li Jia, Paul F. Robbins, Isaac R. Kriley, Yasmine Assadipour, Steven A. Rosenberg, Steven A. Feldman, Stephanie L. Goff, Jared J. Gartner, Nikolaos Zacharakis, Jessica S. Crystal, John R. Wunderlich, Yong-Chen Lu, Robert Somerville, Mary A. Black, Lily Lu, Hui Xu, Zhili Zheng
Publikováno v:
Clinical Cancer Research. 23:4347-4353
Purpose: The administration of autologous tumor-infiltrating lymphocytes (TILs) can mediate durable tumor regressions in patients with melanoma likely based on the recognition of immunogenic somatic mutations expressed by the cancer. There are limite
Autor:
Steven A. Rosenberg, Arvind Sabesan, John R. Wunderlich, David N. Danforth, Christopher A. Klebanoff, Stephanie L. Goff, Mary Ann Toomey, Liqiang Xi, Daniel Zlott, Robert Somerville, James Chih-Hsin Yang, Mark Raffeld, Donald E. White, Trinh Hoc Tran Pham, Smita S. Chandran, Richard M. Sherry, Abhishek K. Srivastava, Udai S. Kammula, Biman C. Paria
Publikováno v:
The Lancet Oncology. 18:792-802
Summary Background Uveal melanoma is a rare tumour with no established treatments once metastases develop. Although a variety of immune-based therapies have shown efficacy in metastatic cutaneous melanoma, their use in ocular variants has been disapp
Autor:
John R. Wunderlich, Daniel J. Stephens, Liqiang Xi, Biman C. Paria, Smita S. Chandran, Arvind Sabesan, Mark Raffeld, Parthav Jailwala, Manjula Kasoji, Robert Somerville, Chyi-Chia Richard Lee, Trinh Hoc Tran Pham, Luke D. Rothermel, Abhishek K. Srivastava, Udai S. Kammula
Publikováno v:
Clinical Cancer Research. 22:2237-2249
Purpose: Uveal melanoma is a rare melanoma variant with no effective therapies once metastases develop. Although durable cancer regression can be achieved in metastatic cutaneous melanoma with immunotherapies that augment naturally existing antitumor
Autor:
John R. Wunderlich, Robert Somerville, Udai S. Kammula, James Chih-Hsin Yang, Richard M. Sherry, Steven A. Rosenberg, Sarah R. Helman, Mei Li M. Kwong, Michelle M. Langhan, Christopher A. Klebanoff, Stacey L. Doran, Christian S. Hinrichs, Sanja Stevanović
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(5)
Purpose: Cellular therapy is an emerging cancer treatment modality, but its application to epithelial cancers has been limited. This clinical trial evaluated tumor-infiltrating lymphocyte (TIL) therapy for the treatment of patients with metastatic hu
Publikováno v:
Cancer Research. 76:OT1-01
Background: Adoptive transfer of tumor infiltrating lymphocytes (TIL) can cure patients with metastatic melanoma, likely based on the recognition of mutated neoantigens (Robbins et al Nature Medicine 2013). Although immunogenic cancer antigens have b