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Autor:
Wissam Zam, Lina Ali
Publikováno v:
Current Reviews in Clinical and Experimental Pharmacology. 17:103-113
Background: Immunotherapy drugs, known as immune checkpoint inhibitors (ICIs), work by blocking checkpoint proteins from binding with their partner proteins. The two main pathways that are specifically targeted in clinical practice are cytotoxic T-ly
Publikováno v:
Neuroscientist
Both sepsis and treatment of cancer with chemotherapy are known to cause neurologic dysfunction. The primary defects seen in both groups of patients are neuropathy and encephalopathy; the underlying mechanisms are poorly understood. Analysis of precl
Autor:
Bei Zhang, Wenzhuo He, Dongsheng Zhang, Xiuxing Chen, Fenghua Wang, Yixing Wang, Qi Quan, Guifang Guo
Publikováno v:
Current Oncology, Vol 28, Iss 23, Pp 209-219 (2021)
Current Oncology
Volume 28
Issue 1
Pages 23-219
Current Oncology
Volume 28
Issue 1
Pages 23-219
Background: There have not been any head-to-head prospective studies to compare the effects of different chemotherapy regimens as first-line treatments for unresectable pancreatic cancer (UPC). We aimed to compare the effectiveness of nab-paclitaxel
Autor:
Marie-Laure Poillot, Charles Coutant, Marc Maynadie, Oumar Billa, Patrick Roignot, Sylvain Ladoire, Ariane Mamguem Kamga, Isabelle Desmoulins, Tienhan Sandrine Dabakuyo-Yonli, Geneviève Jolimoy
Publikováno v:
Breast, Vol 59, Iss, Pp 79-86 (2021)
The Breast : Official Journal of the European Society of Mastology
The Breast : Official Journal of the European Society of Mastology
Purpose To identify prognostic factors of invasive–disease free survival (iDFS) in women with non-metastatic hormone receptor positive (HR+) breast cancer (BC) in daily routine practice. Methods We performed a retrospective study using data from th
Publikováno v:
European Journal of Surgical Oncology. 47:2460-2464
Introduction The induction of adaptive cellular immunity in patients with in-transit melanoma metastasis treated with hyperthermic isolated limb perfusion (ILP) with melphalan has been shown to contribute to the effectiveness of the therapy. Activate
Autor:
T.S. Vatseba
Publikováno v:
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine). 15:217-222
Background. It is proved that patients with diabetes mellitus (DM) have an increased risk of cancer. The main factors of oncogenesis in DM are obesity, cytokine imbalance, hyperinsulinemia (HI), hyperglycemia. These disorders cause dysfunction of the
Autor:
Ting Deng, Xinyi Wang, Guoguang Ying, Hongli Li, Rui Liu, Ming Bai, Jialu Li, Haiyang Zhang, Tao Ning, Kegan Zhu, Qian Fan, Yi He, Yi Ba
Publikováno v:
Molecular Therapy. 29:2723-2736
Oxaliplatin resistance is a challenge in the treatment of colorectal cancer (CRC) patients. Regulatory T cells (Tregs) are well known for their immunosuppressive roles, and targeting Tregs is an effective way to improve chemosensitivity. Exosome-deli
Publikováno v:
Trends Cancer
Biguanides are a class of anti-diabetic drugs that includes phenformin and metformin, however, the former was withdrawn from approval in many countries due to its toxicity. Findings from retrospective epidemiological studies in diabetic populations a
Publikováno v:
Cancer Medicine, Vol 10, Iss 15, Pp 5246-5255 (2021)
Cancer Medicine
Cancer Medicine
Background Recent studies highlight the regulatory role of arachidonate lipoxygenase5 (Alox5) and its metabolite 5‐hydroxyeicosatetraenoic acid (5‐HETE) in cancer tumorigenesis and progression. In this study, we analyzed the expression, biologica
Publikováno v:
Ural Medical Journal. 20:17-22
Introduction.Of greatest interest in the complex treatment of gastric cancer is the assessment of the effect of perioperative chemotherapy on the immediate and long-term results of treatment. Including, the possibility of studying the effectiveness o