Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Robert Somerville"'
Autor:
Scott Kivitz, Gal Cafri, Drew C. Deniger, Steven A. Rosenberg, Parisa Malekzadeh, Paul F. Robbins, Biman C. Paria, Rami Yossef, Mark Raffeld, Nicholas P. Restifo, Amy R. Copeland, Satyajit Ray, Maria R. Parkhurst, Robert Somerville, Sang-hyun Kim, Meghan L. Good, Zhiya Yu, Abraham Sachs, Liqiang Xi, Frank J. Lowery, Mohammad S. Jafferji
Publikováno v:
Clin Cancer Res
Purpose: The purpose of this study was to evaluate antigen experienced T cells in peripheral blood lymphocytes (PBL) for responses to p53 neoantigens. Experimental Design: PBLs from patients with a mutated TP53 tumor were sorted for antigen-experienc
Autor:
John R. Wunderlich, Robert Somerville, Udai S. Kammula, James Chih-Hsin Yang, Richard M. Sherry, Steven A. Rosenberg, Sarah R. Helman, Mei Li M. Kwong, Michelle M. Langhan, Christopher A. Klebanoff, Stacey L. Doran, Christian S. Hinrichs, Sanja Stevanović
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(5)
Purpose: Cellular therapy is an emerging cancer treatment modality, but its application to epithelial cancers has been limited. This clinical trial evaluated tumor-infiltrating lymphocyte (TIL) therapy for the treatment of patients with metastatic hu
Autor:
Steven A. Rosenberg, Tangying Lily Lu, Omar Pugach, Robert Somerville, Steven A. Feldman, James N. Kochenderfer, Marc Better
Publikováno v:
Human gene therapy methods. 27(6)
The treatment of B-cell malignancies by adoptive cell transfer (ACT) of anti-CD19 chimeric antigen receptor T cells (CD19 CAR-T) has proven to be a highly successful therapeutic modality in several clinical trials.(1–6) The anti-CD19 CAR-T cell pro
Autor:
Steven A. Rosenberg, Mark Roschewski, Udai S. Kammula, Stephanie L. Goff, Allen Xue, Tangying Lu, Robert Somerville, Arianne Perez, Marika Sherman, Jonathan W. Friedberg, Tatyana Feldman, Richard M. Sherry, James N. Kochenderfer, Lori McIntyre, John J. Rossi, Adrian Bot, Victoria Shi, James Chih-Hsin Yang, Steven R. Feldman, Christopher A. Klebanoff
Publikováno v:
Journal of Clinical Oncology. 34:LBA3010-LBA3010
LBA3010 Background: T cells genetically-modified to express chimeric antigen receptors (CARs) targeting CD19 have potent activity against a variety of B-cell malignancies. Chemotherapy is administered prior to CAR T cells because depletion of recipie