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Autor:
Teena Mohan, Larisa V. Gubareva
Publikováno v:
Cold Spring Harbor perspectives in medicine. 12(1)
The neuraminidase (NA) of influenza A and B viruses plays a distinct role in viral replication and has a highly conserved catalytic site. Numerous sialic (neuraminic) acid analogs that competitively bind to the NA active site and potently inhibit enz
Autor:
Kenneth K.-S. Ng, A. Iqbal, Mark G. Kris, Maria E. Arcila, Helena A. Yu, Linda Ahn, Jia Luo, Yosef Tobi, Sara A. Hayes, Alex Makhnin, Gregory J Riely
Publikováno v:
JCO Precision Oncology. :55-64
PURPOSE Inhibition of the MEK/ERK pathway is critical for Bcl-2-like protein 11 (BIM)-mediated epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)-induced apoptosis, and dysregulation of this pathway may be a mechanism of acquired
Autor:
Johanna Lilja, Ella-Maria Vesilahti, Johanna M. Anttila, Hussein Al-Akhrass, Johanna Ivaska, Emilia Peuhu, Pauliina Munne, Mika Pietilä, Juha Klefström, Heidi M. Haikala
Publikováno v:
Molecular Oncology
Molecular Oncology, Vol 16, Iss 1, Pp 116-129 (2022)
Molecular Oncology, Vol 16, Iss 1, Pp 116-129 (2022)
In breast cancer, the currently approved anti‐receptor tyrosine‐protein kinase erbB‐2 (HER2) therapies do not fully meet the expected clinical goals due to therapy resistance. Identifying alternative HER2‐related therapeutic targets could off
Publikováno v:
GASTROENTEROLOGY. :25-29
The article deals with the treatment of Helicobater pylori infection. We consider the regimens, which are currently recommended for use and matched the recent data of evidence-based medicine. According to a survey conducted in 2015 in Ukraine, first-
Autor:
Hongyun Zhao, Wenxiu Yao, Xuhong Min, Kangsheng Gu, Guohua Yu, Zhonghan Zhang, Jiuwei Cui, Liyun Miao, Li Zhang, Xia Yuan, Yong Fang, Xiuhua Fu, Chengping Hu, Xiaoli Zhu, Yun Fan, Qitao Yu, Gang Wu, Ou Jiang, Xiuping Du, Jiwei Liu, Wei Gu, Zhiguo Hou, Quanren Wang, Rongrong Zheng, Xianfeng Zhou
Publikováno v:
Journal of Thoracic Oncology. 16:1533-1546
Introduction Blocking vascular endothelial growth factor pathway can enhance the efficacy of EGFR tyrosine kinase inhibitors in EGFR-mutant NSCLC. ACTIVE is the first phase 3 study conducted in the People's Republic of China evaluating apatinib, a va
Publikováno v:
Biochemical and Biophysical Research Communications. 567:56-62
Human circadian rhythm refers to the intrinsic ∼24-h oscillation that regulates biological processes to adapt to environments. Disruption of rhythmicity causes mitochondrial dysfunction, changes metabolism, and is associated with neurodegenerative
Publikováno v:
Pathology. 53:639-644
Summary The objective of this study was to review the antifungal susceptibility of clinical mould isolates performed by the New Zealand Mycology Reference Laboratory. Isolates were either local or referred for testing from other New Zealand laborator
Autor:
Stephen V. Liu
Publikováno v:
Lung Cancer. 158:25-28
NRG1 fusions are rare oncogenic drivers that exist at low frequencies across multiple tumor types. They are uncommon in lung cancer with an estimated incidence of 0.2 %. NRG1 fusions have a unique biology and are challenging to detect, due to large i
Publikováno v:
Russian Journal of Pediatric Hematology and Oncology. 8:61-72
Introduction. So far there has been no clear protocol on the treatment of bacterial infections in hematopoietic cancer patients undergoing polychemotherapy (PCT) and hematopoietic stem cell transplantation (HSCT). Guidelines available from antibiotic
Autor:
Aguslina Kirtishanti, Siswandono Siswodihardjo, I Ketut Sudiana, Aristika Dinaryanti, Desak G A Suprabawati
Publikováno v:
Journal of Basic and Clinical Physiology and Pharmacology. 32:363-371
Objectives Human epidermal growth factor receptor type 2 (HER2)-expressing breast cancer patients indicate poor prognosis in disease progression. HER2 overexpression can increase activities of Ras-mitogen activated protein kinase (Ras-MAPK) pathway a