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Autor:
Prakash Priyadarshi Praharaj, Debasna P. Panigrahi, Bishnu Prasad Behera, Kewal Kumar Mahapatra, Shankargouda Patil, Amruta Singh, Rohan Dhiman, Srimanta Patra, Soumya Ranjan Mishra, Chandra Sekhar Bhol, Sujit K. Bhutia, Samir Kumar Patra
Publikováno v:
Seminars in Cancer Biology. 83:399-412
Tumour-promoting inflammation is a critical hallmark in cancer development, and inflammasomes are well-known regulators of inflammatory processes within the tumour microenvironment. Different inflammasome components along with the adaptor, apoptosis-
Publikováno v:
Biomedical Journal. 44:694-708
Background Pancreatic cancer is one of the most notorious cancers and is known for its highly invasive characteristics, drug resistance, and metastatic progression. Unfortunately, resistance towards gemcitabine develops in many with advanced pancreat
Publikováno v:
Biochemistry and Cell Biology. 99:457-464
Numerous studies have indicated that microRNAs (miRNAs) play critical roles in the development and progression of cancer. However, how changes to the expression levels of miRNAs in response to dexmedetomidine affects the progression of lung cancer re
Publikováno v:
Immunotherapy. 13:1053-1065
PD-L1 is an important predictive biomarker for treatment by immune checkpoint inhibitors (ICIs). ICIs are now indicated for the treatment of various cancer depending on the level of expression of PD-L1 on tumor cells. PD-L1 testing is done using immu
Publikováno v:
Trends Cancer
Autophagy is a catabolic intracellular nutrient scavenging pathway triggered by nutrient deprivation and stress that captures and degrades intracellular proteins and organelles in lysosomes. The breakdown products are then recycled into metabolic pat
Autor:
Chih-Wei Lin, Richard A. Lerner, Alex R. Nanna, Christoph Rader, Geramie Grande, Tianqing Zheng
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports
Triple-negative breast cancer (TNBC) is a highly diverse group of malignant neoplasms which tend to have poor outcomes, and the development of new targets and strategies to treat these cancers is sorely needed. Antibody–drug conjugate (ADC) therapy
Autor:
Wenkai Zhu, Yunxian Dong, Pu Cheng, Yue Yan, Changlin Zhang, Jiayuan Zhu, Wuguo Deng, Bing Tang, Shaobin Huang, Xiaoling Cao, Miao Chen, Peng Wang, Dingbo Shi, Zhicheng Hu, Chuanbo Xie, Hailin Xu
Publikováno v:
Oncogene
We identified fermitin family member 2 (FERMT2, also known as kindlin-2) as a potential target in A375 cell line by siRNA library screening. Drugs that target mutant BRAF kinase lack durable efficacy in the treatment of melanoma because of acquired r
Autor:
Rajeev Kharb
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 21:1338-1349
Anticancer is a high priority research area for scientists as cancer is one of the leading causes of death globally. It is pertinent to mention here that conventional anticancer drugs such as methotrexate, vincristine, cyclophosphamide, etoposide, do
Autor:
Zhirui Fan, Jie Zhao, Wenhua Xue, Zhibo Shen, Yuanyuan Zheng, Yunkai Zhai, Ying Yue, Geng Qishun, Lifeng Li, Wang Wenbin, Le Wang
Publikováno v:
Cancer Cell International, Vol 21, Iss 1, Pp 1-15 (2021)
Cancer Cell International
Cancer Cell International
Background Hepatocyte growth factor (HGF) binds to the c-mesenchymal-epithelial transition (C-MET) receptor and activates downstream signaling pathways, playing an essential role in the development of various cancers. Given the role of this signaling
Autor:
Gary K. Hulse, Albert Stuart Reece
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-21 (2021)
Scientific Reports
Scientific Reports
Cannabis and cannabinoids are implicated in multiple genotoxic, epigenotoxic and chromosomal-toxic mechanisms and interact with several morphogenic pathways, likely underpinning previous reports of links between cannabis and congenital anomalies and