Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Hyun Jung Jun"'
Autor:
Jann N. Sarkaria, Al Charest, Alan T. Yeo, Hemant Varma, Hyun Jung Jun, Piyan Zhang, Vicky A. Appleman
Publikováno v:
Oncogene
Focal amplification of epidermal growth factor receptor (EGFR) and its ligand-independent, constitutively active EGFRvIII mutant form are prominent oncogenic drivers in glioblastoma (GBM). The EGFRvIII gene rearrangement is considered to be an initia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2055620846f5a097df337437e360d728
https://europepmc.org/articles/PMC9159289/
https://europepmc.org/articles/PMC9159289/
Autor:
Timothy J. Mitchison, Al Charest, Keith L. Ligon, Ennio Antonio Chiocca, Aron Gyuris, Alan T. Yeo, Franziska Michor, Jann N. Sarkaria, Ichiro Nakano, Hua-Jun Wu, Agnieszka Bronisz, Steve P. Gygi, Roderick T. Bronson, Bethany Delcuze, Charlotte E. Lee, Steve Woolfenden, Javier Pineda, Hyun Jung Jun, Christopher M. Rose, Haihao Zhu, Vicky A. Appleman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
Glioblastoma multiforme (GBM) is an aggressive primary brain cancer that includes focal amplification of PDGFRα and for which there are no effective therapies. Herein, we report the development of a genetically engineered mouse model of GBM based on