Zobrazeno 1 - 10
of 356
pro vyhledávání: '"Preclinical research"'
Publikováno v:
Journal of Women's Health
Background: In 2015, the National Institutes of Health (NIH) established a policy on sex as a biological variable (SABV) in an effort to address the overrepresentation of men and male animals in biomedical research and the lack of attention to sex-ba
Autor:
Robert D. Johnston, Caitríona Lally, Celine Smekens, Alan J. Stone, Syed Salman Shahid, Christian Kerskens, Robert Gaul, Brooke Tornifoglio
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
The purpose of this study was to characterize the alterations in microstructural organization of arterial tissue using higher-order diffusion magnetic resonance schemes. Three porcine carotid artery models namely; native, collagenase treated and dece
Autor:
Greg Jensen, Vincent P. Ferrera, Nancy Kwon, Mark Burgess, Elisa E. Konofagou, Robin Ji, Fabian Munoz, Hermes A. S. Kamimura, Andrew F. Teich, Antonios N. Pouliopoulos, Alicia J McLuckie, Anna Meaney, Yusuke Niimi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
An emerging approach with potential in improving the treatment of neurodegenerative diseases and brain tumors is the use of focused ultrasound (FUS) to bypass the blood–brain barrier (BBB) in a non-invasive and localized manner. A large body of pre
Autor:
Tod E. Kippin, Kristina N. Elias, Kalysta N. Holder, Brooke D. Barger, Alvin S. Chiu, Laura L. Huerta Sanchez, Karen K. Szumlinski, Christina B. Shin, Matthew C. Kang, C. Leonardo Jimenez Chavez, Anne M. Fabella
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol 46, iss 12
Neuropsychopharmacology
Neuropsychopharmacology
Cue-elicited drug-craving is a cardinal feature of addiction that intensifies (incubates) during protracted withdrawal. In a rat model, these addiction-related behavioral pathologies are mediated, respectively, by time-dependent increases in PI3K/Akt
Autor:
Lin Chen, Elisha Johnston, Andrew Kochan, Jason A. Junge, David Rabago, Michael Johnston, Yi Kou
Publikováno v:
Cartilage
Objective Hypertonic dextrose (HD) injections (prolotherapy) for osteoarthritis are reported to reduce pain. Cartilage regeneration is hypothesized as a mechanism. This in vitro study identifies an HD concentration that stimulates chondrogenic cells
Autor:
Lee E. Fisher, Liane Wong, Bryan McLaughlin, Charles C. Horn, Jonathan A. Shulgach, Michael Sciullo, Derek M. Miller, Ameya C. Nanivadekar, Bill J. Yates, Dylan W. Beam, John I. Ogren, Stephanie Fulton
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Dysfunction and diseases of the gastrointestinal (GI) tract are a major driver of medical care. The vagus nerve innervates and controls multiple organs of the GI tract and vagus nerve stimulation (VNS) could provide a means for affecting GI function
Autor:
Aleksander A. Mathé, Pia Steensland, Philippe A. Melas, Malin Wirf, Helder André, Nitya Jayaram-Lindström
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Alcohol use disorders (AUD) often co-occur with anxiety and depressive disorders, and anxiety often drives relapse during alcohol abstinence. Optimal AUD pharmacotherapies may thus need to target both excessive alcohol intake and elevated anxiety. (
Autor:
Timir Datta-Chaudhuri
Publikováno v:
Bioelectronic Medicine, Vol 7, Iss 1, Pp 1-10 (2021)
Bioelectronic Medicine
Bioelectronic Medicine
Mouse models have been of tremendous benefit to medical science for the better part of a century, yet bioelectronic medicine research using mice has been limited to mostly acute studies because of a lack of tools for chronic stimulation and sensing.
Autor:
Opa Vajragupta, Peththa Wadu Dasuni Wasana, Pornchai Rojsitthisak, Pasarapa Towiwat, Hasriadi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Scientific Reports
Scientific Reports
The failure to develop analgesic drugs is attributed not only to the complex and diverse pathophysiology of pain in humans but also to the poor experimental design and poor preclinical assessment of pain. Although considerable efforts have been devot
Autor:
Sophie Zaaijer, Amanda Capes-Davis
Publikováno v:
Cell. 184:2525-2531
Human cell lines (CLs) are key assets for biomedicine but lack ancestral diversity. Here, we explore why genetic diversity among cell-based models is essential for making preclinical research more equitable and widely translatable. We lay out practic