Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Megumi Aimoto"'
Autor:
Tatsuo Chiba, Kazuhiro Shimizu, Tomoyuki Yamamoto, Chikao Miyazaki, Kiyoshi Sakuma, Akira Takahara, Nobuo Sugo, Mao Takahashi, Yoshinobu Nagasawa, Megumi Aimoto, Kohji Shirai
Publikováno v:
Journal of Atherosclerosis and Thrombosis
Aim: Stroke is well known to lead to hypertension; nevertheless, the role of vascular function in hypertension remains unclear. In this study, we aimed to clarify the mechanism underlying increased arterial stiffness following stroke. Methods: The ca
Autor:
Megumi Aimoto, Akira Takahara, Mihoko Hagiwara-Nagasawa, Satoshi Kawakami, Kensuke Omura, Yoshinobu Nagasawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 144, Iss 3, Pp 123-128 (2020)
We assessed the torsadogenic effects of a novel remyelinating drug clemastine for multiple sclerosis using an in vivo proarrhythmia model of acute atrioventricular block rabbit, since the drug has been demonstrated to suppress the human ether-a-go-go
Publikováno v:
Journal of Pharmacological Sciences, Vol 142, Iss 1, Pp 34-40 (2020)
Atrial dilation is an independent risk factor for the development of atrial fibrillation (AF) and modulates the efficacy of anti-AF drugs, leading to the unsatisfactory control of AF. Pre-clinical studies showed anti-AF effects of acehytisine, a mult
Publikováno v:
Journal of Pharmacological Sciences, Vol 141, Iss 4, Pp 153-159 (2019)
Experimental evidence regarding the risk of proarrhythmic potential of acehytisine is limited. We assessed its electropharmacological effect together with proarrhythmic potential at intravenous doses of 4 and 10 mg/kg (n = 6) using isoflurane-anesthe
Autor:
Megumi Aimoto, Mao Takahashi, Tatsuo Chiba, Kohji Shirai, Kazuhiro Shimizu, Yuichi Hori, Xin Cao, Kiyoshi Sakuma, Akira Takahara, Yoshinobu Nagasawa, Tetsuya Komatsu
Publikováno v:
Journal of Pharmacological Sciences, Vol 139, Iss 1, Pp 42-45 (2019)
We assessed effects of acetylcholine and Nω-Nitro-l-arginine methyl ester hydrochloride (l-NAME) on the cardio-ankle vascular index (CAVI), an indicator of arterial stiffness from origin of aorta to tibial artery, in halothane-anesthetized rabbits.
Autor:
Yuichi Hori, Yoshinobu Nagasawa, Tetsuya Komatsu, Akira Takahara, Kento Watanabe, Kiyoshi Sakuma, Megumi Aimoto, Tomoaki Shiba
Publikováno v:
Microcirculation (New York, N.Y. : 1994)REFERENCES. 28(7)
Purpose To clarify the continuous changes in the retinal vessels' and choroid's microcirculation during hemorrhagic shock and resuscitation in a rabbit model. Methods Hemorrhagic shock by the removal of blood (30 mL) and resuscitation by a blood-retu
Autor:
Kaori Sakai, Megumi Aimoto, Yoshinobu Nagasawa, Akira Takahara, Satoshi Kawakami, Rui Kurimoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 143, Iss 1, Pp 39-44 (2020)
We investigated effects of isoflurane and sevoflurane on sparfloxacin-induced QT-interval prolongation in guinea pigs under the monitoring of electrocardiogram and monophasic action potential (MAP), which was compared with those of halothane or non-i
Autor:
Yoshinobu Nagasawa, Akira Takahara, Megumi Aimoto, Ryuichi Kambayashi, Kazuhiro Takada, Seiji Shibuta, Misako Nakajo, Mihoko Hagiwara
Publikováno v:
British Journal of Pharmacology. 174:2591-2605
Background and purpose Several rabbit proarrhythmia models have been recently developed by genetic or pharmacological methods to suppress the slow component of delayed rectifier K+ currents in the ventricle, leading to reduction of the repolarization
Autor:
Yuichi Hori, Kento Watanabe, Hiroaki Shiratori, Tatsuo Chiba, Kohji Shirai, Kiyoshi Sakuma, Yoshinobu Nagasawa, Akira Takahara, Akira Shimoda, Tetsuya Komatsu, Megumi Aimoto
Publikováno v:
Journal of Pharmacological Sciences, Vol 140, Iss 2, Pp 205-209 (2019)
The cardio-ankle vascular index (CAVI) has been established as a stiffness indicator from thoracic aorta to tibial arteries. To better understand physiological regulatory factors for the arterial stiffness, we assessed effects of angiotensin II and a
Publikováno v:
Journal of Pharmacological Sciences, Vol 132, Iss 1, Pp 48-54 (2016)
We assessed electrophysiological effects of an atypical antipsychotic drug paliperidone in acute atrioventricular block rabbits. Intravenous administration of paliperidone at a clinically relevant dose (0.06 mg/kg) hardly affected the QT interval or