Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jesse R. Dixon"'
Autor:
Dmitry A. Gordenin, Jesse R. Dixon, Sarah Killcoyne, Erica Lynn, Peter J. Campbell, Manjunath Nimmakayalu, Rebecca C. Fitzgerald, Yanyan Tian, Sahil Seth, Yonathan Lissanu Deribe, John P. O'Brien, Akira Inoue, Victoria T. Le, Roel G.W. Verhaak, Kadir C. Akdemir, Leszek J. Klimczak, Moritz Gerstung, Rafael E. Herrera, Ya-Ping Lin, Lei Li, Justin M. Kim, Samirkumar B. Amin, P. Andrew Futreal, Frederick S. Robinson, Kin Chan, Ashby J. Morrison, Devin A. King
Publikováno v:
Nat Genet
Somatic mutations in driver genes may ultimately lead to the development of cancer. Understanding how somatic mutations accumulate in cancer genomes and the underlying factors that generate somatic mutations is therefore crucial for developing novel
Autor:
Michela Traglia, Si-Yao Lu, Li Gan, Kenneth Wu, Bingkun Li, Lenka Maliskova, Guo Li Ming, Bruce R. Conklin, Lauren A. Weiss, Fadi Jacob, Xiaoyu Yang, Kirsty Jamieson, Yin Shen, Michael Song, Tse Wai Tam, Chao Wang, Jesse R. Dixon, Jun Yao, Xingjie Ren, Luke M. Judge, Ian R. Jones, Yun Li, Hongjun Song
Publikováno v:
Nature genetics, vol 51, iss 8
Nature genetics
Nature genetics
Mutations in gene regulatory elements have been associated with a wide range of complex neuropsychiatric disorders. However, due to their cell-type specificity and difficulties in characterizing their regulatory targets, the ability to identify causa
Autor:
Franz Meitinger, Haruhiko Ishii, Jesse R. Dixon, Simona Bianco, Rong Hu, Bin Li, Huimin Zhao, Xiong Xiong, Mario Nicodemi, Bing Ren, James D. Hocker, Miao Yu, Naoki Kubo, Mattia Conte, David U. Gorkin, Ming Hu
Publikováno v:
Nature structural & molecular biology
The CCCTC-binding factor (CTCF) works together with the cohesin complex to drive the formation of chromatin loops and topologically associating domains, but its role in gene regulation has not been fully defined. Here, we investigated the effects of
Autor:
Fred H. Gage, Dylan A. Reid, Jesse R. Dixon, Patrick J. Reed, Shong Lau, Johannes C. M. Schlachetzki, Enoch C. Tsui, Jean H. Ooi, Christopher K. Glass, Sahaana Chandran, Nasun Hah, Sara B. Linker, Jeffrey R. Jones, Simon T. Schafer, Grace Chou, Claire A. McClain, Steve Horvath, Anthony S. Ricciardulli, Ake T. Lu
Neurons are the longest-living cells in our bodies, becoming post-mitotic in early development upon terminal differentiation. Their lack of DNA replication makes them reliant on DNA repair mechanisms to maintain genome fidelity. These repair mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2188296bafadf0071a8b44be57581a67
Autor:
Jesse R. Dixon
Publikováno v:
Developmental Cell. 51:131-132
In this issue of Developmental Cell, Anderson et al. (2019) show that chromatin domain structure on the X chromosome in C. elegans is dispensable for dosage compensation but regulates longevity and thermotolerance. This study sheds light on the mecha
Autor:
Jian Peng, Joseph R. Ecker, Terrence J. Sejnowski, Bokan Bao, Jesse R. Dixon, Jianzhu Ma, Jingtian Zhou, Chuankai Cheng, Yusi Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Chromosomes are compactly folded in nuclei, and their specific 3D structures play a role in the regulation of gene expression. While cell type specificity of gene regulation has been revealed through transcriptomic and epigenomic assays,
Autor:
Jesse R. Dixon, Zhichao Xu
Publikováno v:
Brief Funct Genomics
Genomic analysis of individuals or organisms is predicated on the availability of high-quality reference and genotype information. With the rapidly dropping costs of high-throughput DNA sequencing, this is becoming readily available for diverse organ
Autor:
Michael Song, Jun Yao, Kirsty Jamieson, Li Gan, Chao Wang, Yin Shen, Bingkun Li, Jesse R. Dixon, Si-Yao Lu, Kenneth Wu, Guo Li Ming, Fadi Jacob, Michela Traglia, Hongjun Song, Lenka Maliskova, Ian R. Jones, Bruce R. Conklin, Xiaoyu Yang, Tse Wai Tam, Luke M. Judge, Lauren A. Weiss, Xingjie Ren
Mutations in gene regulatory elements have been associated with a wide range of complex neurological disorders. However, due to their inherent cell type-specificity and difficulties in characterizing their regulatory targets, our ability to identify
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93bdb0d43468b74f3a9cf962056d7041
https://doi.org/10.1101/494450
https://doi.org/10.1101/494450
Publikováno v:
Cell Syst
Recent developments in whole-genome mapping approaches for the chromatin interactome (such as Hi-C) have offered new insights into 3D genome organization. However, our knowledge of the evolutionary patterns of 3D genome structures in mammalian specie
Autor:
Bradley E. Bernstein, Yiwen Zhu, Veena Afzal, Malak Shoukry, Jennifer A. Akiyama, Eric M. Mendenhall, Simon C. Biddie, Alexander Nord, Edward M. Rubin, Matthew J. Blow, Len A. Pennacchio, Axel Visel, Roya Hosseini, Bing Ren, Amy Holt, Crystal Wright, Ingrid Plajzer-Frick, Jesse R. Dixon, Catia Attanasio
Publikováno v:
Genome research
Genome research, vol 24, iss 6
Genome research, vol 24, iss 6
The SMARCA4 (also known as BRG1 in humans) chromatin remodeling factor is critical for establishing lineage-specific chromatin states during early mammalian development. However, the role of SMARCA4 in tissue-specific gene regulation during embryogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf6a12ff2ca7be35df94fed90eee863
https://lirias.kuleuven.be/handle/123456789/632135
https://lirias.kuleuven.be/handle/123456789/632135