Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Gil Atzmon"'
Autor:
Zhengdong D. Zhang, Quanwei Zhang, Trina M. Norden-Krichmar, Nicholas J. Schork, Seunggeun Lee, Gil Atzmon, Yousin Suh, Seungjin Ryu, Nir Barzilai, Laura J. Niedernhofer, Jeehae Han, Paul D. Robbins
Publikováno v:
Aging Cell
Gene variants associated with longevity are also associated with protection against cognitive decline, dementia and Alzheimer's disease, suggesting that common physiologic pathways act at the interface of longevity and cognitive function. To test the
Autor:
Schuum P, Daniel B. Graham, Sun D, Seksik P, David T. Okou, Daniel L. Rice, David J. Cutler, Martti Färkkilä, Liefferinckx C, Segal Aw, Andrew T. Chan, Denis Franchimont, Beecham A, Subra Kugathasan, Stacey Gabriel, Stefan Schreiber, Baras A, Kirschner Bs, Goerg S, Juozas Kupcinskas, Jukka Koskela, John C. Mansfield, Kyle Gettler, Devoto M, Dobes A, Debby Laukens, Richard H. Duerr, Myriam Mni, Loescher B, Cosnes J, Mengesha E, William A. Faubion, Joshua Lewis, Graham A. Heap, Voskuil, Christine Stevens, Pekow J, Lisa W. Datta, Adam P. Levine, Khalili H, O’Charoen S, Dan Turner, Nikolas Pontikos, Natalie J. Prescott, Inga Peter, Marc P. Hoeppner, Chung D, Mark S. Silverberg, Dodge S, Talin Haritunians, Moayyedi P, Winter Hs, John D. Rioux, Andre Franke, Holm H. Uhlig, Ferreira M, Matthew Solomonson, Sokol H, Damas Om, Ramnik J. Xavier, Horowitz Je, Iyer, Eija Hämäläinen, Avila B, Dawany N, Newberry R, Bernstein C, Shawky R, Benjamin Glaser, Alison Simmons, Mamta Giri, Bruce E. Sands, Ann E. Pulver, Yuan K, Abreu Mt, Gil Atzmon, Allez M, Young J, Verstockt S, Aarno Palotie, Hongyan Huang, Kimmo Kontula, Ellinghaus E, van der Meulen Ae, Ahmad T, Oldenburg B, Cyriel Y. Ponsioen, Daly A, Dermot P.B. McGovern, Jeffrey C. Barrett, Peter M. Irving, Miles Parkes, Jacob L. McCauley, Päivi Saavalainen, Pierik Mj, Alain Bitton, Guhan Venkataraman, Rinse K. Weersma, Schiff Er, Manuel A. Rivas, Harry Ostrer, Bokemeyer B, Judy H. Cho, Sandra May, Michel Georges, Isabelle Cleynen, Moran Cj, Laudes M, Beaugerie L, Laura Fachal, Nir Barzilai, Mikko Hiltunen, Somineni H, Stephan R. Targan, Skeiceviciene J, Kelsen J, Sartor Br, Christopher A. Lamb, Philippe Goyette, Steven R. Brant, Souad Rahmouni, Mark J. Daly, Sheikh Sz, Edouard Louis, Jalas C, Carl A. Anderson, Severine Vermeire, Aleksejs Sazonovs
Genome-wide association studies (GWAS) have identified hundreds of loci associated with Crohns disease (CD), however, as with all complex diseases, deriving pathogenic mechanisms from these non-coding GWAS discoveries has been challenging. To complem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cb230603fc89c4e9c9583e329f9ebeb
https://doi.org/10.1101/2021.06.15.21258641
https://doi.org/10.1101/2021.06.15.21258641
Autor:
Julia K. Goodrich, Moriel Singer-Berk, Rachel Son, Abigail Sveden, Jordan Wood, Eleina England, Joanne B. Cole, Ben Weisburd, Nick Watts, Lizz Caulkins, Peter Dornbos, Ryan Koesterer, Zachary Zappala, Haichen Zhang, Kristin A. Maloney, Andy Dahl, Carlos A. Aguilar-Salinas, Gil Atzmon, Francisco Barajas-Olmos, Nir Barzilai, John Blangero, Eric Boerwinkle, Lori L. Bonnycastle, Erwin Bottinger, Donald W. Bowden, Federico Centeno-Cruz, John C. Chambers, Nathalie Chami, Edmund Chan, Juliana Chan, Ching-Yu Cheng, Yoon Shin Cho, Cecilia Contreras-Cubas, Emilio Córdova, Adolfo Correa, Ralph A. DeFronzo, Ravindranath Duggirala, Josée Dupuis, Ma Eugenia Garay-Sevilla, Humberto García-Ortiz, Christian Gieger, Benjamin Glaser, Clicerio González-Villalpando, Ma Elena Gonzalez, Niels Grarup, Leif Groop, Myron Gross, Christopher Haiman, Sohee Han, Craig L. Hanis, Torben Hansen, Nancy L. Heard-Costa, Brian E. Henderson, Juan Manuel Malacara Hernandez, Mi Yeong Hwang, Sergio Islas-Andrade, Marit E. Jørgensen, Hyun Min Kang, Bong-Jo Kim, Young Jin Kim, Heikki A. Koistinen, Jaspal Singh Kooner, Johanna Kuusisto, Soo-Heon Kwak, Markku Laakso, Leslie Lange, Jong-Young Lee, Juyoung Lee, Donna M. Lehman, Allan Linneberg, Jianjun Liu, Ruth J. F. Loos, Valeriya Lyssenko, Ronald C. W. Ma, Angélica Martínez-Hernández, James B. Meigs, Thomas Meitinger, Elvia Mendoza-Caamal, Karen L. Mohlke, Andrew D. Morris, Alanna C. Morrison, Maggie C. Y. Ng, Peter M. Nilsson, Christopher J. O’Donnell, Lorena Orozco, Colin N. A. Palmer, Kyong Soo Park, Wendy S. Post, Oluf Pedersen, Michael Preuss, Bruce M. Psaty, Alexander P. Reiner, Cristina Revilla-Monsalve, Stephen S. Rich, Jerome I. Rotter, Danish Saleheen, Claudia Schurmann, Xueling Sim, Rob Sladek, Kerrin S. Small, Wing Yee So, Timothy D. Spector, Konstantin Strauch, Tim M. Strom, E. Shyong Tai, Claudia H. T. Tam, Yik Ying Teo, Farook Thameem, Brian Tomlinson, Russell P. Tracy, Tiinamaija Tuomi, Jaakko Tuomilehto, Teresa Tusié-Luna, Rob M. van Dam, Ramachandran S. Vasan, James G. Wilson, Daniel R. Witte, Tien-Yin Wong, AMP-T2D-GENES Consortia, Noël P. Burtt, Noah Zaitlen, Mark I. McCarthy, Michael Boehnke, Toni I. Pollin, Jason Flannick, Josep M. Mercader, Anne O’Donnell-Luria, Samantha Baxter, Jose C. Florez, Daniel G. MacArthur, Miriam S. Udler
Publikováno v:
Nature Communications
Goodrich, J K, Singer-Berk, M, Son, R, Sveden, A, Wood, J, England, E, Cole, J B, Weisburd, B, Watts, N, Caulkins, L, Dornbos, P, Koesterer, R, Zappala, Z, Zhang, H, Maloney, K A, Dahl, A, Aguilar-Salinas, C A, Atzmon, G, Barajas-Olmos, F, Barzilai, N, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E, Bowden, D W, Centeno-Cruz, F, Chambers, J C, Chami, N, Chan, E, Chan, J, Cheng, C Y, Cho, Y S, Contreras-Cubas, C, Córdova, E, Correa, A, DeFronzo, R A, Duggirala, R, Dupuis, J, Garay-Sevilla, M E, García-Ortiz, H, Gieger, C, Glaser, B, González-Villalpando, C, Gonzalez, M E, Grarup, N, Groop, L, Gross, M, Hansen, T, Linneberg, A, Pedersen, O & AMP-T2D-GENES Consortia 2021, ' Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes ', Nature Communications, vol. 12, 3505 . https://doi.org/10.1038/s41467-021-23556-4
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Goodrich, J K, Singer-Berk, M, Son, R, Sveden, A, Wood, J, England, E, Cole, J B, Weisburd, B, Watts, N, Caulkins, L, Dornbos, P, Koesterer, R, Zappala, Z, Zhang, H, Maloney, K A, Dahl, A, Aguilar-Salinas, C A, Atzmon, G, Barajas-Olmos, F, Barzilai, N, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E, Bowden, D W, Centeno-Cruz, F, Chambers, J C, Chami, N, Chan, E, Chan, J, Cheng, C Y, Cho, Y S, Contreras-Cubas, C, Córdova, E, Correa, A, DeFronzo, R A, Duggirala, R, Dupuis, J, Garay-Sevilla, M E, García-Ortiz, H, Gieger, C, Glaser, B, González-Villalpando, C, Gonzalez, M E, Grarup, N, Groop, L, Gross, M, Haiman, C A, Han, S, Hanis, C L, Hansen, T, Heard-Costa, N L, Jørgensen, M E, Pedersen, O, Witte, D R & AMP-T2D-GENES Consortia 2021, ' Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes ', Nature Communications, vol. 12, 3505 . https://doi.org/10.1038/s41467-021-23556-4
AMP-T2D-GENES Consortia 2021, ' Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes ', Nature Communications, vol. 12, no. 1, 3505 . https://doi.org/10.1038/s41467-021-23556-4
Goodrich, J K, Singer-Berk, M, Son, R, Sveden, A, Wood, J, England, E, Cole, J B, Weisburd, B, Watts, N, Caulkins, L, Dornbos, P, Koesterer, R, Zappala, Z, Zhang, H, Maloney, K A, Dahl, A, Aguilar-Salinas, C A, Atzmon, G, Barajas-Olmos, F, Barzilai, N, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E, Bowden, D W, Centeno-Cruz, F, Chambers, J C, Chami, N, Chan, E, Chan, J, Cheng, C Y, Cho, Y S, Contreras-Cubas, C, Córdova, E, Correa, A, DeFronzo, R A, Duggirala, R, Dupuis, J, Garay-Sevilla, M E, García-Ortiz, H, Gieger, C, Glaser, B, González-Villalpando, C, Gonzalez, M E, Grarup, N, Groop, L, Gross, M, Hansen, T, Linneberg, A, Pedersen, O & AMP-T2D-GENES Consortia 2021, ' Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes ', Nature Communications, vol. 12, 3505 . https://doi.org/10.1038/s41467-021-23556-4
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Goodrich, J K, Singer-Berk, M, Son, R, Sveden, A, Wood, J, England, E, Cole, J B, Weisburd, B, Watts, N, Caulkins, L, Dornbos, P, Koesterer, R, Zappala, Z, Zhang, H, Maloney, K A, Dahl, A, Aguilar-Salinas, C A, Atzmon, G, Barajas-Olmos, F, Barzilai, N, Blangero, J, Boerwinkle, E, Bonnycastle, L L, Bottinger, E, Bowden, D W, Centeno-Cruz, F, Chambers, J C, Chami, N, Chan, E, Chan, J, Cheng, C Y, Cho, Y S, Contreras-Cubas, C, Córdova, E, Correa, A, DeFronzo, R A, Duggirala, R, Dupuis, J, Garay-Sevilla, M E, García-Ortiz, H, Gieger, C, Glaser, B, González-Villalpando, C, Gonzalez, M E, Grarup, N, Groop, L, Gross, M, Haiman, C A, Han, S, Hanis, C L, Hansen, T, Heard-Costa, N L, Jørgensen, M E, Pedersen, O, Witte, D R & AMP-T2D-GENES Consortia 2021, ' Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes ', Nature Communications, vol. 12, 3505 . https://doi.org/10.1038/s41467-021-23556-4
AMP-T2D-GENES Consortia 2021, ' Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes ', Nature Communications, vol. 12, no. 1, 3505 . https://doi.org/10.1038/s41467-021-23556-4
Hundreds of thousands of genetic variants have been reported to cause severe monogenic diseases, but the probability that a variant carrier develops the disease (termed penetrance) is unknown for virtually all of them. Additionally, the clinical util
Autor:
Paola Sebastiani, Stacy L. Andersen, Gil Atzmon, Anastasia Gurinovich, Stefano Monti, Thomas T. Perls, Harold Bae, John J. Farrell, Nir Barzilai, Annibale Alessandro Puca
Publikováno v:
Bioinformatics
Motivation Over the last decade, more diverse populations have been included in genome-wide association studies. If a genetic variant has a varying effect on a phenotype in different populations, genome-wide association studies applied to a dataset a
Autor:
Marju Orho-Melander, Humberto García-Ortiz, Xueling Sim, Amp-T D-Genes, Cheol Joo Park, Gina M. Peloso, Jason Flannick, Brian Tomlinson, Hyun Min Kang, Emilio J. Cordova, Stephen S. Rich, Richard A. Gibbs, Angélica Martínez-Hernández, Lorena Orozco, Harsha Doddapaneni, Lisa R. Yanek, Jiwon Lee, Namrata Gupta, Valeriya Lyssenko, Sohee Han, James B. Meigs, Bong-Jo Kim, Bruce M. Psaty, Leslie S. Emery, Kerrin S. Small, Pradeep Natarajan, May E. Montasser, Christian Gieger, Sharon L.R. Kardia, Sarah C. Nelson, Craig L. Hanis, Heikki A. Koistinen, María Elena González-Villalpando, Edmund Chan, Michael Y. Tsai, Benjamin Glaser, Thomas Meitinger, Matthew J. Bown, Mariaelisa Graff, John Danesh, Sekar Kathiresan, Tiinamaija Tuomi, Ramachandran S. Vasan, Gil Atzmon, Alyna T. Khan, Diego Ardissino, Yii-Der Ida Chen, David Zhang, Rob M. van Dam, Wendy S. Post, Barry I. Freedman, D. C. Rao, Michael Preuss, Donna M. Lehman, L. Adrienne Cupples, Colin N. A. Palmer, Claudia H. T. Tam, Hortensia Moreno-Macías, Markku Laakso, Peter Dornbos, Teresa Tusié-Luna, Stella Aslibekyan, Marguerite R. Irvin, Daniel J. Rader, Jee-Young Moon, Eimear E. Kenny, Lisa W. Martin, Jennifer A. Brody, Amit Khera, Erwin P. Bottinger, Sarah E. Graham, Myriam Fornage, Ruth McPherson, Nancy L. Heard-Costa, Michael Boehnke, Clicerio Gonzalez, Ryan W. Kim, Yi-Cheng Chang, Peter M. Nilsson, Yik Ying Teo, Robert Sladek, Cristen J. Willer, Fei Fei Wang, Donna K. Arnett, Mark Chaffin, Karine A. Viaud Martinez, Alanna C. Morrison, Leslie A. Lange, Ravindranath Duggirala, Donna M. Muzny, Kent D. Taylor, Niels Grarup, Soren Germer, Patricia A. Peyser, Brian E. Cade, Lewis C. Becker, Steven A. Lubitz, Nicholette D. Palmer, Susan K. Dutcher, Ronald C.W. Ma, Xuenan Mi, Xiuqing Guo, Hugh Watkins, Eric Boerwinkle, Qibin Qi, Johanna Kuusisto, Christie M. Ballantyne, Tanika N. Kelly, Rajiv Chowdhury, Elvia Mendoza-Caamal, Wing-Yee So, Tien Yin Wong, Torben Hansen, Cecilia Contreras-Cubas, Jeong-Sun Seo, Mi Yeong Hwang, Daekwan Seo, Dajiang J. Liu, Cristina Revilla-Monsalve, Paul S. de Vries, Daniel R. Witte, Yi-Jen Hung, Olle Melander, Karen L. Mohlke, Lucinda Antonacci-Fulton, Francisco Barajas-Olmos, Soo Heon Kwak, Daniel E. Weeks, Claudia Schurmann, Ginger A. Metcalf, Young-Jin Kim, Adrienne M. Stilp, Lori L. Bonnycastle, John Blangero, Ralph A. DeFronzo, Donald W. Bowden, Rasika A. Mathias, Oluf Pedersen, Rozenn N. Lemaitre, Stephen T. McGarvey, Heribert Schunkert, Jaakko Tuomilehto, Farook Thameem, Valentin Fuster, Joshua C. Bis, George Hindy, Allan Linneberg, James G. Wilson, Kyong Soo Park, Sergio A. Islas-Andrade, Ching-Yu Cheng, Won Jung Choi, Minxian X. Wang, Xuzhi Wang, Adolfo Correa, Jai G. Broome, Gail P. Jarvik, Alexander P. Reiner, E. Shyong Tai, Juyoung Lee, Mark I. McCarthy, Nilesh J. Samani, Susan Redline, Carlos A. Aguilar-Salinas, Jerome I. Rotter, Ma. Eugenia Garay-Sevilla, Jiang He, Patrick T. Ellinor, Joseph Park, Joanne E. Curran, Nir Barzilai, Federico Centeno-Cruz, Seonwook Lee, Lawrence F. Bielak, Jianjun Liu, Charles Kooperberg, Juan M. Peralta, Jose C. Florez, Leif Groop, Noël P. Burtt, Margaret Sunitha Selvaraj, Jeffrey R. O'Connell, Ruth J. F. Loos
Large-scale gene sequencing studies for complex traits have the potential to identify causal genes with therapeutic implications. We performed gene-based association testing of blood lipid levels with rare (minor allele frequency170,000 individuals f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08cffcbe73ed87d1953f10593c831399
https://doi.org/10.1101/2020.12.22.423783
https://doi.org/10.1101/2020.12.22.423783
Autor:
Joris Deelen, Claudia Gonzaga-Jauregui, Patrick Sin-Chan, Tina Gao, Nir Barzilai, Gil Atzmon, A. R. Shuldiner, Danielle Gutman, Gabriel Lidzbarsky, Sofiya Milman
Publikováno v:
Aging Cell
Centenarians (exceptionally long‐lived individuals—ELLI) are a unique segment of the population, exhibiting long human lifespan and healthspan, despite generally practicing similar lifestyle habits as their peers. We tested disease‐associated m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f57c04ba6647f6174f7c13f9f88b2d
https://hdl.handle.net/21.11116/0000-000B-2D86-C
https://hdl.handle.net/21.11116/0000-000B-2D86-C
Autor:
Lorraine N. Clark, Tom Maniatis, Harry Ostrer, Raiyan R. Khan, Nir Barzilai, Shai Carmi, Joseph Vijai, Laurie J. Ozelius, Max Lam, Danny Ben-Avraham, Susan B. Bressman, Anil K. Malhotra, Judy H. Cho, Ariel Darvasi, Erin Flaherty, Kenneth Offit, Steven M. Lipkin, Jin Yu, Robert J. Klein, Todd Lencz, Itsik Pe'er, Zeynep H. Gümüş, Gil Atzmon, Inga Peter
IMPORTANCE Schizophrenia is a serious mental illness with high heritability. While common genetic variants account for a portion of the heritability, identification of rare variants associated with the disorder has proven challenging. OBJECTIVE To id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23aefb1891776e69c84332fec4abb3ce
https://doi.org/10.1101/2020.05.29.20115352
https://doi.org/10.1101/2020.05.29.20115352
Autor:
Robert P. Adelson, Yun Freudenberg-Hua, Alison Goate, Nir Barzilai, Gil Atzmon, Peter Davies, Jeremy Koppel, Brian Fulton-Howard, Marc L. Gordon
Publikováno v:
Neurobiol Aging
To evaluate how age and apolipoprotein E-e4 (APOE4) status interact with APOE-independent polygenic risk score (PRSnon-APOE), we estimated PRSnon-APOE in superagers (age ≥ 90 years, N = 346), 89− controls (age 60–89, N = 2930), and Alzheimer's
Autor:
Meenakshi Ravichandran, Michael Ristow, Leonid Rozanov, Giovanna Grigolon, Gil Atzmon, Kim Zarse, Fabian Fischer, Nir Barzilai, Maria Clara Zanellati, Johannes Mansfeld
Publikováno v:
Redox Biology
Redox Biology, 32
Redox Biology, Vol 32, Iss, Pp-(2020)
Redox Biology, 32
Redox Biology, Vol 32, Iss, Pp-(2020)
Physiological aging is a complex process, influenced by a plethora of genetic and environmental factors. While being far from fully understood, a number of common aging hallmarks have been elucidated in recent years. Among these, transcriptomic alter
Autor:
Jerome I. Rotter, Rachel Duncan, Lenore J. Launer, Iris E. Jansen, Sarah Cubaynes, Nir Barzilai, Elizabeth J. Becker, Wiesje M. van der Flier, Joris Deelen, Sharon L.R. Kardia, Birgit Debrabant, Wanlin Zheng, Michael A. Province, Janina Dose, Anne B. Newman, Vilmundur Gudnason, Carol Jagger, Kenny Ye, Gil Atzmon, Carmen Martin-Ruiz, Kathryn L. Lunetta, Claudio Franceschi, Marianne Nygaard, Diana van Heemst, Najaf Amin, P. Eline Slagboom, Thomas B. L. Kirkwood, Ilkka Seppälä, Chloé Sarnowski, Heather J. Cordell, Terho Lehtimäki, Jennifer A. Smith, Cornelia M. van Duijn, Marja Jylhä, Dan E. Arking, Hélène Blanché, Jessica D. Faul, Yi Zeng, Henne Holstege, Kent D. Taylor, Junxia Min, Alice M. Arnold, Kristin L. Ayers, Mika Kähönen, Olli T. Raitakari, Pilar Galan, Mary K. Wojczynski, Jean-Marie Robine, Lene Christiansen, David R. Weir, Karen Davies, J. Collerton, Kaare Christensen, Douglas P. Kiel, Niccolò Tesi, Andrew Kingston, Bruce M. Psaty, Joanne M. Murabito, Marcel J. T. Reinders, Albert V. Smith, Xiaomin Liu, Leo-Pekka Lyytikäinen, Mary L. Biggs, Almut Nebel, Sven J. van der Lee, Mikko Hurme, David Karasik, Jean-François Deleuze, Thomas T. Perls, Erin B. Ware, Martijn Huisman, Marian Beekman, Chao Nie, Tamara B. Harris, Ellen A. Nohr, Eric S. Orwoll, Steven R. Cummings, Paola Sebastiani, James W. Vaupel, Wolfgang Lieb, Daniel S. Evans, Thorkild I. A. Sørensen, André G. Uitterlinden, Ashley van der Spek
Publikováno v:
Deelen, J, Evans, D S, Arking, D E, Tesi, N, Nygaard, M, Liu, X, Wojczynski, M K, Biggs, M L, van der Spek, A, Atzmon, G, Ware, E B, Sarnowski, C, Smith, A V, Seppälä, I, Cordell, H J, Dose, J, Amin, N, Arnold, A M, Ayers, K L, Barzilai, N, Becker, E J, Beekman, M, Blanché, H, Christensen, K, Christiansen, L, Collerton, J C, Cubaynes, S, Cummings, S R, Davies, K, Debrabant, B, Deleuze, J F, Duncan, R, Faul, J D, Franceschi, C, Galan, P, Gudnason, V, Harris, T B, Huisman, M, Hurme, M A, Jagger, C, Jansen, I, Jylhä, M, Kähönen, M, Karasik, D, Kardia, S L R, Kingston, A, Kirkwood, T B L, Launer, L J, Lehtimäki, T, Lieb, W, Lyytikäinen, L P, Martin-Ruiz, C, Min, J, Nebel, A, Newman, A B, Nie, C, Nohr, E A, Orwoll, E S, Perls, T T, Province, M A, Psaty, B M, Raitakari, O T, Reinders, M J T, Robine, J M, Rotter, J I, Sebastiani, P, Smith, J, Sørensen, T I A, Taylor, K D, Uitterlinden, A G, van der Flier, W, van der Lee, S J, van Duijn, C M, van Heemst, D, Vaupel, J W, Weir, D, Ye, K, Zeng, Y, Zheng, W, Holstege, H, Kiel, D P, Lunetta, K L, Slagboom, P E & Murabito, J M 2019, ' A meta-analysis of genome-wide association studies identifies multiple longevity genes ', Nature Communications, vol. 10, no. 1, 3669 . https://doi.org/10.1038/s41467-019-11558-2
Nature Communications
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-11558-2⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-11558-2⟩
Deelen, J, Evans, D S, Arking, D E, Tesi, N, Nygaard, M, Liu, X, Wojczynski, M K, Biggs, M L, van der Spek, A, Atzmon, G, Ware, E B, Sarnowski, C, Smith, A V, Seppälä, I, Cordell, H J, Dose, J, Amin, N, Arnold, A M, Ayers, K L, Barzilai, N, Becker, E J, Beekman, M, Blanché, H, Christensen, K, Christiansen, L, Collerton, J C, Cubaynes, S, Cummings, S R, Davies, K, Debrabant, B, Deleuze, J F, Duncan, R, Faul, J D, Franceschi, C, Galan, P, Gudnason, V, Harris, T B, Huisman, M, Hurme, M A, Jagger, C, Jansen, I, Jylhä, M, Kähönen, M, Karasik, D, Kardia, S L R, Kingston, A, Kirkwood, T B L, Launer, L J, Lehtimäki, T, Lieb, W, Lyytikäinen, L P, Martin-Ruiz, C, Min, J, Nebel, A, Newman, A B, Nie, C, Nohr, E A, Orwoll, E S, Perls, T T, Province, M A, Psaty, B M, Raitakari, O T, Reinders, M J T, Robine, J M, Rotter, J I, Sebastiani, P, Smith, J, Sørensen, T I A, Taylor, K D, Uitterlinden, A G, van der Flier, W, van der Lee, S J, van Duijn, C M, van Heemst, D, Vaupel, J W, Weir, D, Ye, K, Zeng, Y, Zheng, W, Holstege, H, Kiel, D P, Lunetta, K L, Slagboom, P E & Murabito, J M 2019, ' A meta-analysis of genome-wide association studies identifies multiple longevity genes ', Nature Communications, vol. 10, 3669 (2019) . https://doi.org/10.1038/s41467-019-11558-2
Nature Communications, 10(1):3669. Nature Publishing Group UK
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 10(1)
Nature communications, vol 10, iss 1
Nature Communications, 10:3669. Nature Publishing Group
Nature Communications, 10
Deelen, J, Evans, D S, Arking, D E, Tesi, N, Nygaard, M, Liu, X, Wojczynski, M K, Biggs, M L, van Der Spek, A, Atzmon, G, Ware, E B, Sarnowski, C, Smith, A V, Seppala, I, Cordell, H J, Dose, J, Amin, N, Arnold, A M, Ayers, K L, Barzilai, N, Becker, E J, Beekman, M, Blanche, H, Christensen, K, Christiansen, L, Collerton, J C, Cubaynes, S, Cummings, S R, Davies, K, Debrabant, B, Deleuze, J-F, Duncan, R, Faul, J D, Franceschi, C, Galan, P, Gudnaso, V, Harris, T B, Huisman, M, Hurme, M A, Jagger, C, Jansen, I, Jylha, M, Kahonen, M, Karasik, D, Kardia, S L R, Kingston, A, Kirkwood, T B L, Launer, L J, Lehtimaki, T, Lieb, W, Lyytikainen, L-P, Martin-Ruiz, C, Min, J, Nebe, A, Newman, A B, Nie, C, Nohr, E A, Orwoll, E S, Perls, T T, Province, M A, Psat, B M, Raitakari, O T, Reinders, M J T, Robine, J-M, Rotter, J I, Sebastiani, P, Smith, J, Sørensen, T I A, D Taylor, K, Uitterlinden, A G, van Der Flier, W, van Der Lee, S J, van Duijn, C M, van Heemst, D, Vaupel, J W, Weir, D, Ye, K, Zeng, Y, Zheng, W, Holstege, H, Kiel, D P, Lunetta, K L, Slagboom, P E & Murabito, J M 2019, ' A meta-analysis of genome-wide association studies identifies multiple longevity genes ', Nature Communications, vol. 10, 3669 . https://doi.org/10.1038/s41467-019-11558-2
Nat Commun
Nature Communications
Nature Communications, 2019, 10 (1), ⟨10.1038/s41467-019-11558-2⟩
Nature Communications, Nature Publishing Group, 2019, 10 (1), ⟨10.1038/s41467-019-11558-2⟩
Deelen, J, Evans, D S, Arking, D E, Tesi, N, Nygaard, M, Liu, X, Wojczynski, M K, Biggs, M L, van der Spek, A, Atzmon, G, Ware, E B, Sarnowski, C, Smith, A V, Seppälä, I, Cordell, H J, Dose, J, Amin, N, Arnold, A M, Ayers, K L, Barzilai, N, Becker, E J, Beekman, M, Blanché, H, Christensen, K, Christiansen, L, Collerton, J C, Cubaynes, S, Cummings, S R, Davies, K, Debrabant, B, Deleuze, J F, Duncan, R, Faul, J D, Franceschi, C, Galan, P, Gudnason, V, Harris, T B, Huisman, M, Hurme, M A, Jagger, C, Jansen, I, Jylhä, M, Kähönen, M, Karasik, D, Kardia, S L R, Kingston, A, Kirkwood, T B L, Launer, L J, Lehtimäki, T, Lieb, W, Lyytikäinen, L P, Martin-Ruiz, C, Min, J, Nebel, A, Newman, A B, Nie, C, Nohr, E A, Orwoll, E S, Perls, T T, Province, M A, Psaty, B M, Raitakari, O T, Reinders, M J T, Robine, J M, Rotter, J I, Sebastiani, P, Smith, J, Sørensen, T I A, Taylor, K D, Uitterlinden, A G, van der Flier, W, van der Lee, S J, van Duijn, C M, van Heemst, D, Vaupel, J W, Weir, D, Ye, K, Zeng, Y, Zheng, W, Holstege, H, Kiel, D P, Lunetta, K L, Slagboom, P E & Murabito, J M 2019, ' A meta-analysis of genome-wide association studies identifies multiple longevity genes ', Nature Communications, vol. 10, 3669 (2019) . https://doi.org/10.1038/s41467-019-11558-2
Nature Communications, 10(1):3669. Nature Publishing Group UK
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications, 10(1)
Nature communications, vol 10, iss 1
Nature Communications, 10:3669. Nature Publishing Group
Nature Communications, 10
Deelen, J, Evans, D S, Arking, D E, Tesi, N, Nygaard, M, Liu, X, Wojczynski, M K, Biggs, M L, van Der Spek, A, Atzmon, G, Ware, E B, Sarnowski, C, Smith, A V, Seppala, I, Cordell, H J, Dose, J, Amin, N, Arnold, A M, Ayers, K L, Barzilai, N, Becker, E J, Beekman, M, Blanche, H, Christensen, K, Christiansen, L, Collerton, J C, Cubaynes, S, Cummings, S R, Davies, K, Debrabant, B, Deleuze, J-F, Duncan, R, Faul, J D, Franceschi, C, Galan, P, Gudnaso, V, Harris, T B, Huisman, M, Hurme, M A, Jagger, C, Jansen, I, Jylha, M, Kahonen, M, Karasik, D, Kardia, S L R, Kingston, A, Kirkwood, T B L, Launer, L J, Lehtimaki, T, Lieb, W, Lyytikainen, L-P, Martin-Ruiz, C, Min, J, Nebe, A, Newman, A B, Nie, C, Nohr, E A, Orwoll, E S, Perls, T T, Province, M A, Psat, B M, Raitakari, O T, Reinders, M J T, Robine, J-M, Rotter, J I, Sebastiani, P, Smith, J, Sørensen, T I A, D Taylor, K, Uitterlinden, A G, van Der Flier, W, van Der Lee, S J, van Duijn, C M, van Heemst, D, Vaupel, J W, Weir, D, Ye, K, Zeng, Y, Zheng, W, Holstege, H, Kiel, D P, Lunetta, K L, Slagboom, P E & Murabito, J M 2019, ' A meta-analysis of genome-wide association studies identifies multiple longevity genes ', Nature Communications, vol. 10, 3669 . https://doi.org/10.1038/s41467-019-11558-2
Nat Commun
Publisher's version (útgefin grein).
Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,2
Human longevity is heritable, but genome-wide association (GWA) studies have had limited success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity phenotype definition including 11,2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3a88b4958a73940da5bc4dfccc45db
https://research.vumc.nl/en/publications/a839f1ac-c346-4dbf-b050-b6610e9f7364
https://research.vumc.nl/en/publications/a839f1ac-c346-4dbf-b050-b6610e9f7364