Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Doron Merkler"'
Publikováno v:
Nature reviews. Neurology. 17(7)
The pathophysiology of complex neuroimmunological diseases, such as multiple sclerosis and autoimmune encephalitis, remains puzzling - various mechanisms that are difficult to dissect seem to contribute, hampering the understanding of the processes i
Autor:
Anja Schmalz, Mario Kreutzfeldt, Anne Jacobi, Florence M. Bareyre, Kristina Loy, Tobias Hoche, Doron Merkler
Publikováno v:
Journal of Neurotrauma, Vol. 35, No 24 (2018) pp. 2904-2915
Recent reports suggest that rehabilitation measures that increase physical activity of patients can improve functional outcome after incomplete spinal cord injuries (iSCI). To investigate the structural basis of exercise-induced recovery, we examined
Autor:
Ingrid Wagner, Giovanni Di Liberto, Doron Merkler, Bogna Klimek, Jonathan Kaye, Nicolas Page, Alexandre Mariotte, Sylvain Lemeille, Ilena Vincenti
Publikováno v:
Nature Communications, Vol. 12, No 1 (2021) P. 1009
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Self-reactive CD8+ T cells are important mediators of progressive tissue damage in autoimmune diseases, but the molecular program underlying these cells’ functional adaptation is unclear. Here we characterize the transcriptional and epigenetic land
Autor:
Lisa Woodworth, Mario Kreutzfeldt, Ingrid Wagner, Fred Wolf, Nellwyn Hagan, Tradite Neziraj, Dimitry Ofengeim, Tanja Jürgens, Joseph Gans, Emily M. Ullrich Gavilanes, Nicolas Snaidero, Thomas Misgeld, Eduardo Beltrán, Juan Daniel Flórez Weidinger, Mehrnoosh Jafari, Adrian-Minh Schumacher, Virág Kocsis-Jutka, Martin Kerschensteiner, Daniel Engels, Ruben Portugues, Doron Merkler, Stephanie S. Schmidt
Publikováno v:
Nature Neuroscience
Nature Neuroscience (2021)
Nature neuroscience 24(3), 355-367 (2021). doi:10.1038/s41593-020-00780-7
Nature Neuroscience (2021)
Nature neuroscience 24(3), 355-367 (2021). doi:10.1038/s41593-020-00780-7
Cortical pathology contributes to chronic cognitive impairment of patients suffering from the neuroinflammatory disease multiple sclerosis (MS). How such gray matter inflammation affects neuronal structure and function is not well understood. In the
Autor:
Thomas Höllbacher, Wolfgang Brück, Klaus Seelos, Tania Kümpfel, Matthias Mäurer, Nathalie L. Albert, Imke Metz, Achim Gass, Christine Stadelmann, Birgit Ertl-Wagner, Christoph Mahler, Joachim Havla, Markus Krumbholz, Maximilian Patzig, Peter Bartenstein, Julia Neitzel, Vladimir M. Milenkovic, Doron Merkler, Simon Lindner, Marcus Unterrainer, Martin Kerschensteiner, Adrian-Minh Schumacher, Lena Kaiser
Publikováno v:
Brain (2021)
Progressive multifocal leukoencephalopathy (PML) is a severe infection of the CNS caused by the polyomavirus JC that can occur in multiple sclerosis patients treated with natalizumab. Clinical management of patients with natalizumab-associated PML is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a59711c2e96c877252f783cf38ea77
https://archive-ouverte.unige.ch/unige:151695
https://archive-ouverte.unige.ch/unige:151695
Autor:
Ingrid Wagner, Dirk H. Busch, Giovanni Di Liberto, Simon P. Fräßle, Sarah Dötsch, Thomas Korn, Christopher Sie, Doron Merkler, Benjamin Knier, Meike Mitsdoerffer, Lilian Aly, Mario Kreutzfeldt, Monika Pfaller
Publikováno v:
Brain (2021)
Brain
Brain
Meningeal B lymphocyte aggregates have been described in autopsy material of patients with chronic multiple sclerosis. The presence of meningeal B cell aggregates has been correlated with worse disease. However, the functional role of these meningeal
Autor:
Nina Steinemann, Jens Kuhle, Pasquale Calabrese, Jürg Kesselring, Giulio Disanto, Doron Merkler, Caroline Pot, Vladeta Ajdacic-Gross, Stephanie Rodgers, Milo Alan Puhan, Viktor von Wyl, the Swiss Multiple Sclerosis Registry
Publikováno v:
BMC Neurology, Vol 18, Iss 1, Pp 1-10 (2018)
BMC neurology, vol. 18, no. 1, pp. 111
BMC Neurology
Steinemann, Nina; Kuhle, Jens; Calabrese, Pasquale; Kesselring, Jürg; Disanto, Giulio; Merkler, Doron; Pot, Caroline; Ajdacic-Gross, Vladeta; Rodgers, Stephanie; Puhan, Milo Alan; von Wyl, Viktor (2018). The Swiss Multiple Sclerosis Registry (SMSR): study protocol of a participatory, nationwide registry to promote epidemiological and patient-centered MS research. BMC neurology, 18(1), p. 111. BioMed Central 10.1186/s12883-018-1118-0
BMC Neurology, Vol. 18, No 1 (2018) P. 111
BMC neurology, vol. 18, no. 1, pp. 111
BMC Neurology
Steinemann, Nina; Kuhle, Jens; Calabrese, Pasquale; Kesselring, Jürg; Disanto, Giulio; Merkler, Doron; Pot, Caroline; Ajdacic-Gross, Vladeta; Rodgers, Stephanie; Puhan, Milo Alan; von Wyl, Viktor (2018). The Swiss Multiple Sclerosis Registry (SMSR): study protocol of a participatory, nationwide registry to promote epidemiological and patient-centered MS research. BMC neurology, 18(1), p. 111. BioMed Central 10.1186/s12883-018-1118-0
BMC Neurology, Vol. 18, No 1 (2018) P. 111
Multiple sclerosis (MS) is one of the most frequently observed neurological conditions in Switzerland, but data sources for country-wide epidemiological trend monitoring are lacking. Moreover, while clinical and laboratory MS research are generally w
Autor:
Dimitry Ofengeim, Fred Wolf, Emily M. Ullrich Gavilanes, Nicolas Snaidero, Tradite Neziraj, Nellwyn Hagan, Thomas Misgeld, Lisa Woodworth, Eduardo Beltrán, Juan Daniel Flórez Weidinger, Joseph Gans, Ruben Portugues, Adrian-Minh Schumacher, Mehrnoosh Jafari, Martin Kerschensteiner, Stephanie S. Schmidt, Tanja Jürgens, Doron Merkler, Mario Kreutzfeldt
SUMMARYCortical pathology contributes to chronic cognitive impairment of patients suffering from the neuroinflammatory disease multiple sclerosis (MS). How such gray matter inflammation affects neuronal structure and function is not well understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54a0d61e55c15ba450d643f7c621a0a6
https://doi.org/10.1101/758193
https://doi.org/10.1101/758193
Autor:
Nicolas Page, Doron Merkler, Ingrid Wagner, Mario Kreutzfeldt, Mary-Aude Rochat, Claire Chevalier, Dilay Cansever, Olivia Bejuy, Karin Steinbach, Nicolas Suárez-Zamorano, Martina Spiljar, Didier J. Colin, Ilena Vincenti, Ozren Stojanović, Mirko Trajkovski, Matthias Mack, Noushin Hadadi, Bogna Klimek, Dorothée Rigo, Melanie Greter
Publikováno v:
Cell Metabolism
Cell metabolism, Vol. 33, No 11 (2021) pp. 2231-2246.e8
Cell metabolism, Vol. 33, No 11 (2021) pp. 2231-2246.e8
Summary Autoimmunity is energetically costly, but the impact of a metabolically active state on immunity and immune-mediated diseases is unclear. Ly6Chi monocytes are key effectors in CNS autoimmunity with an elusive role in priming naive autoreactiv
Autor:
Niek de Vries, Anja ten Brinke, Felix M. Wensveen, Niels A. W. Lemmermann, Erik Slinger, Eric Eldering, Doron Merkler, Inga Kavazović, Jan Koster, Hongya Han, Bojan Polić, Stipan Jonjić, Giulia Balzaretti, Yenan T. Bryceson, Paul L. Klarenbeek
Publikováno v:
PLoS Biology
PLOS Biology, Vol. 18, No 3 (2020) P. e3000648
PLoS Biology, Vol 18, Iss 3, p e3000648 (2020)
PLoS biology, 18(3):e3000648. Public Library of Science
PLOS Biology
Volume 18
Issue 3
PLOS Biology, Vol. 18, No 3 (2020) P. e3000648
PLoS Biology, Vol 18, Iss 3, p e3000648 (2020)
PLoS biology, 18(3):e3000648. Public Library of Science
PLOS Biology
Volume 18
Issue 3
The memory CD8 T-cell pool must select for clones that bind immunodominant epitopes with high affinity to efficiently counter reinfection. At the same time, it must retain a level of clonal diversity to allow recognition of pathogens with mutated epi