Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alfredo Castello"'
Autor:
Connor G. G. Bamford, Milagros Rodriguez Collados, Alfredo Castello, Srikeerthana Kuchi, David Robertson, Nardus Mollentze, Sam J. Wilson, Joseph Busby, Arthur Wickenhagen, Douglas G. Stewart, Richard J. Orton, Siddharth Bakshi, Quan Gu, Elena Sugrue, Matthew L. Turnbull, Daniel G. Streicker, Massimo Palmarini, Suzannah J. Rihn, Andrew Shaw, Ana Filipe da Silva, Paul C. D. Johnson, Katherine Smollett
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated int
Autor:
Ilan Davis, Peter J. Ratcliffe, Alfredo Castello, William James, Jeffrey Y. Lee, Maria Prange-Barczynska, Marko Noerenberg, Jane A. McKeating, Craig Thompson, Senko Tsukuda, Koichi Watashi, Isobel L.A. Argles, Thomas P. Keeley, Sophie B. Morgan, Peter A C Wing, Samvid Kurlekar, Kuan-Ying A. Huang, Xiaodong Zhuang, Timothy S. C. Hinks, Tammie Bishop, Peter Balfe, Emma J. Hodson, Adam Harding
Publikováno v:
Cell Reports
Cell Reports, Vol 35, Iss 3, Pp 109020-(2021)
Cell Reports, Vol 35, Iss 3, Pp 109020-(2021)
COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment and one important factor to consider is oxygen tension, where hyp
Autor:
Natasha Johnson, Berati Cerikan, Shabaz Mohammed, Manuel Garcia-Moreno, Javier Martinez, Christopher J. Neufeldt, Alfredo Castello, Ralf Bartenschlager, Mohamed Kammoun, Jeffrey Y. Lee, Anna Andrejeva, Mirko Cortese, Marko Noerenberg, Honglin Chen, Kathryn S. Lilley, Ilan Davis, Michael L. Knight, Aino I. Järvelin, Ni Shuai, Wael Kamel, Michael J. Deery
Publikováno v:
Molecular Cell
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19. SARS-CoV-2 relies on cellular RNA-binding proteins (RBPs) to replicate and spread, although which RBPs control its life cycle remains largely unknown. Here, we employ a mul
Publikováno v:
Seminars in Cell & Developmental Biology
Highlights • Proteomic studies have uncovered more than a thousand cellular proteins that are present in the particles of RNA viruses. • Strikingly, nearly four hundred of these are RNA-binding proteins (RBPs). • Several virion-incorporated RBP
Autor:
Caroline E. Lenz, Matthias W. Hentze, Joel I. Perez-Perri, Marko Noerenberg, Shabaz Mohammed, Alfredo Castello, Wael Kamel
Publikováno v:
Nat Protoc
Interactions between RNA-binding proteins (RBPs) and RNAs are critical to cell biology. However, methods to comprehensively and quantitatively assess these interactions within cells were lacking. RNA interactome capture (RIC) uses in vivo UV crosslin
Autor:
Svenja Hester, Krzysztof Kus, Cornelia Kilchert, Emily Priest, Ebru Aydin, Lidia Vasiljeva, Alfredo Castello, Oliver Rossbach, Tea Kecman, Shabaz Mohammed
Large RNA-binding complexes play a central role in gene expression and orchestrate production, function, and turnover of mRNAs. The accuracy and dynamics of RNA–protein interactions within these molecular machines are essential for their function a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ef71188ccb20b10ec41d6dd22f34bb
https://doi.org/10.1101/748194
https://doi.org/10.1101/748194
Autor:
Matthias W. Hentze, Rozemarijn Kleinendorst, Asli Adak, Christian Tischer, Magdalena Büscher, Anne-Marie Alleaume, Rastislav Horos, Thomas Schwarzl, Abul K. Tarafder, Elisabeth M. Zielonka, Dmytro Dziuba, Carsten Sachse, Wolfgang Huber, Alfredo Castello
Vault RNAs (vtRNA) are small non-coding RNAs transcribed by RNA polymerase III found in many eukaryotes. Although they have been linked to drug resistance, apoptosis, and viral replication, their molecular functions remain unclear. Here, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bdd4e41f974bb6b2e479a80750427ed
https://doi.org/10.1016/j.cell.2019.01.030
https://doi.org/10.1016/j.cell.2019.01.030
Publikováno v:
Trends in Endocrinology and Metabolism
In the past century, few areas of biology advanced as much as our understanding of the pathways of intermediary metabolism. Initially considered unimportant in terms of gene regulation, crucial cellular fate changes, cell differentiation, or malignan
Autor:
Marcel Bach-Pages, Victoria Cox, Svenja Hester, Luis Carrasco, T. P. Davis, Marko Noerenberg, Thibault J. M. Sohier, Miguel Angel Sanz, Alfredo Castello, Caroline E. Lenz, Rosario Avolio, Manuel Garcia-Moreno, Shabaz Mohammed, Vicent Pelechano, Bingnan Li, Esther González-Almela, Aino I. Järvelin, Emiliano P. Ricci, Shuai Ni, Bernd Fischer
The compendium of RNA-binding proteins (RBPome) has been greatly expanded by the development of RNA-interactome capture (RNA-IC). However, it remains unknown how responsive is the RBPome and whether these responses are biologically relevant. To answe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11930326133c58287c2358df424805a9
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one or multiple globular RNA-binding domains (RBDs) and change the fate or function of the bound RNAs. Several hundred such RBPs have been discovered and investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b673698addb260e76982715b9b2c4fc
https://eprints.gla.ac.uk/219002/1/219002.pdf
https://eprints.gla.ac.uk/219002/1/219002.pdf