Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Preclinical research"'
Autor:
Shilpa D. Kadam, Brennan J. Sullivan
Publikováno v:
Pediatr Neurol
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has an extensively studied classical role in neuronal growth, differentiation, survival, and plasticity. Neurotrophic, from the Greek neuro and trophos, roughly translates
Autor:
Florent Barthas, Paulina Nunez-Badinez, Raúl Gómez, Francisco Cruz, Jens Nagel, Ana Charrua, Katy Vincent, Alexis Laux-Biehlmann, Stephen B. McMahon, Jane Meijlink, Lone Hummelshoj, J. Douglas Armstrong, Patrick J. Sweeney, Anja Hoffmann, Ioannis Simitsidellis, Laure Lo Re, Philippa T. K. Saunders, Thomas M. Zollner, Miguel Angel Tejada, Judy Birch, Rolf-Detlef Treede, Bianca De Leo
Publikováno v:
Nunez-Badinez, P, De Leo, B, Laux-Biehlmann, A, Hoffmann, A, Zollner, T M, Saunders, P T K, Simitsidellis, I, Charrua, A, Cruz, F, Gomez, R, Tejada, M A, McMahon, S B, Lo Re, L, Barthas, F, Vincent, K, Birch, J, Meijlink, J, Hummelshoj, L, Sweeney, P J, Armstrong, J D, Treede, R-D & Nagel, J 2021, ' Preclinical models of endometriosis and interstitial cystitis/bladder pain syndrome: an Innovative Medicines Initiative-PainCare initiative to improve their value for translational research in pelvic pain ', Pain, vol. 162, no. 9, pp. 2349-2365 . https://doi.org/10.1097/j.pain.0000000000002248
PAIN
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Pain
PAIN
r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname
Pain
Supplemental Digital Content is Available in the Text.
Endometriosis (ENDO) and interstitial cystitis/bladder pain syndrome (IC/BPS) are chronic pain conditions for which better treatments are urgently needed. Development of new therapies with p
Endometriosis (ENDO) and interstitial cystitis/bladder pain syndrome (IC/BPS) are chronic pain conditions for which better treatments are urgently needed. Development of new therapies with p
Autor:
Massieh Moayedi, Abigail J. D’Souza, Sarah F. Rosen, Helena Fetter Filippini, Anastassia Dokova, Vassilia Michailidis, Igor Vukobradovic, Toni-Lee Sterley, Paul D. Whissell, Wai-Jane Virginia Lee, John R. Matyas, Maian Christine Pham, Hantao Zhang, Jeff Biernaskie, Chereen Collymore, David N. Dubins, Ingita Patel, Loren J. Martin, Chulmin Cho, Hayley Crawhall-Duk, Irene Lecker, Jo Anne Stratton, Hendrik W. Steenland, Robert P. Bonin, Jeffrey S. Mogil, Jaideep S. Bains, Ann M. Flenniken, Jerry Li, Alexandr Bezginov, Maham Zain, Megan Valencia
Publikováno v:
Pain
Supplemental Digital Content is Available in the Text. Cage-lid hanging behavior is impaired by sustained pain in mice and can be used as an ethologically valid and translationally relevant pain outcome measure.
The development of new analgesic
The development of new analgesic
Autor:
Leonard H. van den Berg, Philip Van Damme, Caroline Ingre, Philippe Corcia, Ruben P A van Eijk, Christopher J McDermott, Evy Reviers, Orla Hardiman, Adriano Chiò, Mònica Povedano, Kit C.B. Roes, Tessa Kliest, Ammar Al-Chalabi, Markus Weber, Michael A van Es
Publikováno v:
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 21, 496-501
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 21, 7-8, pp. 496-501
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 21, 7-8, pp. 496-501
A change in our current approach toward drug development is required to improve the likelihood of finding effective treatment for patients with amyotrophic lateral sclerosis (ALS). The aim of the Treatment Research Initiative to Cure ALS (TRICALS) is
Publikováno v:
Alcohol
The 2018 Fetal Alcohol Spectrum Disorders Study Group (FASDSG) meeting was entitled “Sex Differences and Vulnerability.” The theme reflected the ongoing NIH initiative to address sex differences in both clinical and preclinical research. The firs
Autor:
Denis Vivien
Publikováno v:
Hämostaseologie. 41:022-024
Ischemic stroke is a leading cause of disability, with its treatment not yet optimal. It is thus mandatory to make preclinical research on this topic more efficient. This review summarizes current development of research aimed to improve diagnosis an
Publikováno v:
Usui, T, Macleod, M R, Mccann, S K, Senior, A M, Nakagawa, S & Boutron, I 2021, ' Meta-analysis of variation suggests that embracing variability improves both replicability and generalizability in preclinical research ', PLoS Biology, vol. 19, no. 5, pp. e3001009 . https://doi.org/10.1371/journal.pbio.3001009
PLoS Biology
PLoS Biology, Vol 19, Iss 5, p e3001009 (2021)
PLoS Biology
PLoS Biology, Vol 19, Iss 5, p e3001009 (2021)
The replicability of research results has been a cause of increasing concern to the scientific community. The long-held belief that experimental standardization begets replicability has also been recently challenged, with the observation that the red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68d881e1085e852c05ddc49c027439af
https://www.pure.ed.ac.uk/ws/files/213608533/journal.pbio.3001009.pdf
https://www.pure.ed.ac.uk/ws/files/213608533/journal.pbio.3001009.pdf
Publikováno v:
Genes Brain Behav
Social hierarchies are ubiquitous features of virtually all animal groups. The varying social ranks of members within these groups have profound effects on both physical and emotional health, with lower-ranked individuals typically being the most adv
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Diffusion tensor imaging (DTI) metrics, such as the fractional anisotropy (FA) and estimates of diffusivity are sensitive to the microstructure of peripheral nerves and may be displayed as tractograms. However, the ideal conditions for tractography o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6e0ff477dafcbaca3533928450c05c0
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-186286
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-186286
Autor:
T. Marissal
Publikováno v:
Revue Neurologique
Revue Neurologique, Elsevier Masson, 2021, ⟨10.1016/j.neurol.2021.02.390⟩
Revue Neurologique, Elsevier Masson, 2021, ⟨10.1016/j.neurol.2021.02.390⟩
Temporal lobe epilepsy is a severe neurological disease, characterized by seizure occurrence and invalidating cognitive co-morbidities, which affects up to 1% of the adults. Roughly one third of the patients are resistant to any conventional pharmaco