Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Preclinical research"'
Autor:
Aleksander A. Mathé, Pia Steensland, Philippe A. Melas, Malin Wirf, Helder André, Nitya Jayaram-Lindström
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Alcohol use disorders (AUD) often co-occur with anxiety and depressive disorders, and anxiety often drives relapse during alcohol abstinence. Optimal AUD pharmacotherapies may thus need to target both excessive alcohol intake and elevated anxiety. (
Autor:
Peter Carmeliet, Louise Deldicque, Sunghoon Kim, Shimin Zhao, Leigh Breen, Gillian Fitzgerald, Koen Veys, Peppi Koivunen, Benoit Smeuninx, Inés Soro-Arnaiz, Katrien De Bock, Bert Blaauw, Gommaar D'Hulst, Evi Masschelein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, vol 11, iss 1
Nature Communications, 11
Nature Communications
Nature Communications, Vol. 11, no. 1, p. 174 (2020)
Nature communications, vol 11, iss 1
Nature Communications, 11
Nature Communications
Nature Communications, Vol. 11, no. 1, p. 174 (2020)
mTORC1 is an important regulator of muscle mass but how it is modulated by oxygen and nutrients is not completely understood. We show that loss of the prolyl hydroxylase domain isoform 1 oxygen sensor in mice (PHD1KO) reduces muscle mass. PHD1KO musc
Autor:
Elena Chiricozzi, Margherita Maggioni, Maria Fazzari, Erika Di Biase, Pamela Fato, Gianluca Verlengia, Gusheng Wu, Diego Yuri Pomè, Simona Prioni, Giulia Lunghi, Laura Mauri, Stefano Cattaneo, Robert Assini, Sandro Sonnino, Robert W. Ledeen, Nicoletta Loberto, Samar K. Alselehdar, Manuela Valsecchi, Maria Grazia Ciampa
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Given the recent in vitro discovery that the free soluble oligosaccharide of GM1 is the bioactive portion of GM1 for neurotrophic functions, we investigated its therapeutic potential in the B4galnt1+/− mice, a model of sporadic Parkinson’s diseas
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
The purpose of this study was to create a new absorbable vascular anastomotic coupler and evaluate the patency and degradation degree. Vascular anastomosis was performed in the jugular vein in 31 New Zealand white female rabbits. The coupler consiste
Autor:
Jorn P. Meekel, Natalija Bogunovic, Kak K. Yeung, Dimitra Micha, Jan D. Blankensteijn, Peter L. Hordijk
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific reports, 9(1):6837. Nature Publishing Group
Scientific Reports
Scientific Reports, 9(1):6837. Nature Publishing Group
Bogunovic, N, Meekel, J P, Micha, D, Blankensteijn, J D, Hordijk, P L & Yeung, K K 2019, ' Impaired smooth muscle cell contractility as a novel concept of abdominal aortic aneurysm pathophysiology ', Scientific Reports, vol. 9, no. 1, 6837 . https://doi.org/10.1038/s41598-019-43322-3
Scientific reports, 9(1):6837. Nature Publishing Group
Scientific Reports
Scientific Reports, 9(1):6837. Nature Publishing Group
Bogunovic, N, Meekel, J P, Micha, D, Blankensteijn, J D, Hordijk, P L & Yeung, K K 2019, ' Impaired smooth muscle cell contractility as a novel concept of abdominal aortic aneurysm pathophysiology ', Scientific Reports, vol. 9, no. 1, 6837 . https://doi.org/10.1038/s41598-019-43322-3
Ruptured abdominal aortic aneurysms (AAA) are associated with overall mortality rates up to 90%. Despite extensive research, mechanisms leading to AAA formation and advancement are still poorly understood. Smooth muscle cells (SMC) are predominant in
Autor:
Atsushi Shimazaki, Takahiro Akaishi, Takazumi Taniguchi, Masatomo Kato, Naoko Yamashita, Masahiro Fuwa, Masafumi Mieda
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
Scientific Reports
Scientific Reports
In this study, we made a comparative efficacy and safety assessment of two different fixed combinations of drugs, viz., tafluprost/timolol (TAF/TIM) and latanoprost/carteolol (LAT/CAR), by determining their effects on intraocular pressure (IOP) in oc
Autor:
Danylo Kaminskyy, Roman Lesyk, Marcin L. Leja, Jan Gmiński, Konrad A. Szychowski, Tadeusz Pomianek, Jakub Tobiasz, Maciej Wnuk, Anna Kryshchyshyn
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
4-thiazolidinones, which are privileged structures in medicinal chemistry, comprise the well-known class of heterocycles and are a source of new drug-like compounds. Undoubtedly, the 5-bulky-substituted-2,4-thiazolidinediones - a class of antihypergl
Novel multimodal molecular imaging of Vitamin H (Biotin) transporter activity in the murine placenta
Autor:
Michal Neeman, Tolulope A. Aweda, Suzanne E. Lapi, Jennifer L. Bartels, Inbal E Bilton, Marina Lysenko, Joel R. Garbow, Rebecca Beacham, Nicholas A Clanton, Noam Ben-Eliezer, Ofra Golani, Solana Fernandez
Publikováno v:
Scientific Reports
Vitamin H (biotin) is delivered to the fetus transplacentally by an active biotin-transport mechanism and is critical for fetal development. Our objective was to develop a comprehensive MRI technique for mapping biotin transporter activity in the mur
Autor:
Kathleen M. Fisch, Khoi Dao, Olivia Osborn, Mohit Jain, Rizaldy C. Zapata, Sara Brin Rosenthal
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific reports, vol 10, iss 1
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific reports, vol 10, iss 1
Antipsychotic drugs (AP) are used to treat a multitude of psychiatric conditions including schizophrenia and bipolar disorder. However, APs also have metabolic side effects including increased food intake and body weight, but the underlying mechanism
Autor:
Hedok Lee, Stefan Constantinou, Xiaodan Liu, Helene Benveniste, Feng Dai, Yuechuan Xue, Sunil Koundal, Laura Santambrogio
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Dynamic contrast-enhanced magnetic resonance imaging (MRI) for tracking glymphatic system transport with paramagnetic contrast such as gadoteric acid (Gd-DOTA) administration into cerebrospinal fluid (CSF) requires pre-contrast data for proper quanti