Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Preclinical research"'
Autor:
Aleksander A. Mathé, Pia Steensland, Philippe A. Melas, Malin Wirf, Helder André, Nitya Jayaram-Lindström
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Alcohol use disorders (AUD) often co-occur with anxiety and depressive disorders, and anxiety often drives relapse during alcohol abstinence. Optimal AUD pharmacotherapies may thus need to target both excessive alcohol intake and elevated anxiety. (
Autor:
Julia A. Tree, Tomas Malinauskas, Mark Howarth, Adrian K. Zagrajek, Veronica Martini, John W. McCauley, Ryan Waters, Jiandong Huo, Jane C. Edwards, Ginette Wilsden, Holly Shelton, Alison Burman, Anna B. Ludi, Rolle Rahikainen, Rod S. Daniels, Isabelle Dietrich, Huang K-Ya., David I. Stuart, Simon P. Graham, M. Pedrera, Valerie Mioulet, Raymond J. Owens, Christopher Chiu, Pramila Rijal, Nazia Thakur, Philippa Hollinghurst, Sushant Bhat, Hayes Jwp., Matthew Tully, Alain Townsend, Miles W. Carroll, Saira Hussain, Clare Browning, Tobias J. Tuthill, Tiong Kit Tan, Katy Moffat, Dagmara Bialy, Rebecca K. McLean, Elma Tchilian, Karen R. Buttigieg, Sylvia Crossley, Ashley R. Gray, Carina Conceicao, Joseph Newman, Phoebe Stevenson-Leggett, Ruth Harvey, Bryan Charleston, Mehreen Azhar, Dalan Bailey, Amin S. Asfor, Duyvesteyn Hme., Anthony H. Keeble, John A. Hammond, Lisa Schimanski
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
There is need for effective and affordable vaccines against SARS-CoV-2 to tackle the ongoing pandemic. In this study, we describe a protein nanoparticle vaccine against SARS-CoV-2. The vaccine is based on the display of coronavirus spike glycoprotein
Autor:
Vahan Kepenekian, Philippe Douek, Pascal Rousset, Pierre-Emmanuel Bonnot, Loic Boussel, Salim Si-Mohamed, Arnaud Thivolet, Christophe Blanchet
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports, 2020, 10 (1), pp.13394. ⟨10.1038/s41598-020-70282-w⟩
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.13394. ⟨10.1038/s41598-020-70282-w⟩
Scientific Reports
Scientific Reports, 2020, 10 (1), pp.13394. ⟨10.1038/s41598-020-70282-w⟩
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.13394. ⟨10.1038/s41598-020-70282-w⟩
Computed tomography imaging plays a major role in the preoperative assessment of tumor burden by providing an accurate mapping of the distribution of peritoneal metastases (PM). Spectral Photon Counting Computed Tomography (SPCCT) is an innovative im
Autor:
Peter Carmeliet, Louise Deldicque, Sunghoon Kim, Shimin Zhao, Leigh Breen, Gillian Fitzgerald, Koen Veys, Peppi Koivunen, Benoit Smeuninx, Inés Soro-Arnaiz, Katrien De Bock, Bert Blaauw, Gommaar D'Hulst, Evi Masschelein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature communications, vol 11, iss 1
Nature Communications, 11
Nature Communications
Nature Communications, Vol. 11, no. 1, p. 174 (2020)
Nature communications, vol 11, iss 1
Nature Communications, 11
Nature Communications
Nature Communications, Vol. 11, no. 1, p. 174 (2020)
mTORC1 is an important regulator of muscle mass but how it is modulated by oxygen and nutrients is not completely understood. We show that loss of the prolyl hydroxylase domain isoform 1 oxygen sensor in mice (PHD1KO) reduces muscle mass. PHD1KO musc
Autor:
Elena Chiricozzi, Margherita Maggioni, Maria Fazzari, Erika Di Biase, Pamela Fato, Gianluca Verlengia, Gusheng Wu, Diego Yuri Pomè, Simona Prioni, Giulia Lunghi, Laura Mauri, Stefano Cattaneo, Robert Assini, Sandro Sonnino, Robert W. Ledeen, Nicoletta Loberto, Samar K. Alselehdar, Manuela Valsecchi, Maria Grazia Ciampa
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Given the recent in vitro discovery that the free soluble oligosaccharide of GM1 is the bioactive portion of GM1 for neurotrophic functions, we investigated its therapeutic potential in the B4galnt1+/− mice, a model of sporadic Parkinson’s diseas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
Classically considered a by-product of anaerobic metabolism, lactate is now viewed as a fundamental fuel for oxidative phosphorylation in mitochondria, and preferred over glucose by many tissues. Lactate is also a signaling molecule of increasing med
Autor:
Mark G Hibberd, Michael Ernest Marino, Adrian Smith, Jason William Castle, Julie Davies, Janell M Crowder, Paul Evans, Michael Larsen, Lisa Lowery
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Gadolinium based contrast agents (GBCA) are used to image patients using magnetic resonance (MR) imaging. In recent years, there has been controversy around gadolinium retention after GBCA administration. We sought to evaluate the potential toxicity
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
The purpose of this study was to create a new absorbable vascular anastomotic coupler and evaluate the patency and degradation degree. Vascular anastomosis was performed in the jugular vein in 31 New Zealand white female rabbits. The coupler consiste
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Processing of complex cell preparations such as blood and peripheral blood progenitor cell (PBPC) transplants using label-free technologies is challenging. Transplant-contaminating neuroblastoma cells (NBCs) can contribute to relapse, and we therefor
Autor:
Jorn P. Meekel, Natalija Bogunovic, Kak K. Yeung, Dimitra Micha, Jan D. Blankensteijn, Peter L. Hordijk
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific reports, 9(1):6837. Nature Publishing Group
Scientific Reports
Scientific Reports, 9(1):6837. Nature Publishing Group
Bogunovic, N, Meekel, J P, Micha, D, Blankensteijn, J D, Hordijk, P L & Yeung, K K 2019, ' Impaired smooth muscle cell contractility as a novel concept of abdominal aortic aneurysm pathophysiology ', Scientific Reports, vol. 9, no. 1, 6837 . https://doi.org/10.1038/s41598-019-43322-3
Scientific reports, 9(1):6837. Nature Publishing Group
Scientific Reports
Scientific Reports, 9(1):6837. Nature Publishing Group
Bogunovic, N, Meekel, J P, Micha, D, Blankensteijn, J D, Hordijk, P L & Yeung, K K 2019, ' Impaired smooth muscle cell contractility as a novel concept of abdominal aortic aneurysm pathophysiology ', Scientific Reports, vol. 9, no. 1, 6837 . https://doi.org/10.1038/s41598-019-43322-3
Ruptured abdominal aortic aneurysms (AAA) are associated with overall mortality rates up to 90%. Despite extensive research, mechanisms leading to AAA formation and advancement are still poorly understood. Smooth muscle cells (SMC) are predominant in