Zobrazeno 1 - 10
of 616
pro vyhledávání: '"11"'
Autor:
Mong Heng Wang, Shu Hsien Huang, Jing Lun Yen, Fan Li Lin, Chih Kuang Chen, Ping Huei Tsai, Po Jen Hsueh, Che Jen Hsiao, Yueh-Hsiung Kuo, George Hsiao
Publikováno v:
Molecules, Vol 26, Iss 2970, p 2970 (2021)
Molecules
Volume 26
Issue 10
Molecules
Volume 26
Issue 10
Intracerebral hemorrhage (ICH) is a devastating neurological disorder characterized by an exacerbation of neuroinflammation and neuronal injury, for which few effective therapies are available at present. Inhibition of excessive neuroglial activation
Autor:
Khalid Hamid El Hachimi, Tine Deconinck, Alessandro Malandrini, Jean Jacques Martin, Giovanni Stevanin, Anne Sieben, Alexis Brice, Michael Gonzales, Federica Zolfanelli, Stephan Züchner, Peter De Jonghe, Carlo Casali, Frédéric Darios, Chantal Ceuterick-de Groote, Filippo M. Santorelli, Paola S. Denora, Dirk Peeters, Katrien Smets
Publikováno v:
Brain
The most common autosomal recessive spastic paraplegia is caused by mutations in SPG11. Denora et al. report the first postmortem neuropathological analysis of two unrelated patients with SPG11, and demonstrate clinical and pathological overlap betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b428b958b294b1b21cd6136d4fa79bbc
http://hdl.handle.net/11365/998591
http://hdl.handle.net/11365/998591
Autor:
Christer Halldin, Andrew P. Brown, Peter Johnström, Mohammad Mahdi Moein, Karthick Vishwanathan, Magnus Schou, Lars Farde, Andrea Varrone, Aurelija Jucaite, Zsolt Cselényi, Ana Vazquez-Romero, Katarina Varnäs
Publikováno v:
J Cereb Blood Flow Metab
Osimertinib is a tyrosine kinase inhibitor (TKI) of the mutated epidermal growth factor receptor (EGFRm) with observed efficacy in patients with brain metastases. Brain exposure and drug distribution in tumor regions are important criteria for evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cefc739fda3d1a79bee1e8a3e1e389df
https://europepmc.org/articles/PMC7168784/
https://europepmc.org/articles/PMC7168784/
Autor:
Eugenii A. Rabiner, Richard Nicholas, Olga Ciccarelli, Roger N. Gunn, David R. Owen, Gourab Datta, Gregory Scott, Anne Lingford-Hughes, Nicola De Stefano, Paul M. Matthews, Nicola J. Kalk, Marco Battaglini, Omar Malik, Lei Nei, Alessandro Colasanti
Objective: To assess microglial activation in lesions and in normal appearing white matter of multiple sclerosis (MS) patients using positron emission tomography (PET). Methods: 34 MS patients (7 with secondary progressive MS (SPMS), 27 with relapsin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96fe515960c4c2dd4c660e1f67580668
http://hdl.handle.net/10044/1/72466
http://hdl.handle.net/10044/1/72466
Autor:
Tomohiko Yamane, Hisashi Doi, Hiroyuki Nishida, Hirotaka Onoe, Shogo Kimoto, Miho Shukuri, Tomoko Mikami, Tomoyuki Nishio, Yasuji Yamamoto, Aya Mawatari, Hiroko Shinkawa, Akihito Ohnishi, Yasuyoshi Watanabe, Kazuki Aita, Yasuhiko Ikari, Masahiro Sasaki, Michio Senda, Go Akamatsu
Publikováno v:
Nuclear medicine and biology. 43(7)
Introduction Neuroinflammatory processes play an important role in the pathogenesis of Alzheimer's disease (AD). As a biomarker of neuroinflammatory processes, we designed 11 C-labeled ketoprofen methyl ester ([ 11 C]KTP-Me) to increase the blood–b
Autor:
Rehima Jordan, Rajesh Narendran, Michael L. Himes, N. Scott Mason, Savannah Tollefson, Joshua Gertler, W. Gordon Frankle
Publikováno v:
Synapse. 72:e22037
Studies in nonhuman primates and humans have demonstrated that amphetamine-induced dopamine release in the cortex can be measured with [(11)C]FLB 457 and PET imaging. This technique has been successfully used in recent clinical studies to show decrea
Publikováno v:
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 36(4)
Tuberous sclerosis complex (TSC) is an uncommon multiorgan disorder that may present many and different manifestations on imaging. Radiology plays an important role in diagnosis and management, and can substantially improve the clinical outcome of TS
Autor:
Stephen C. Cunnane, Jennifer Tremblay-Mercier, Mélanie Plourde, M'hamed Bentourkia, Fabien Pifferi, Sébastien Tremblay
Publikováno v:
Epilepsia
Epilepsia, Wiley, 2008, 49, pp.76-79. ⟨10.1111/j.1528-1167.2008.01842.x⟩
Epilepsia, 2008, 49, pp.76-79. ⟨10.1111/j.1528-1167.2008.01842.x⟩
Epilepsia, Wiley, 2008, 49, pp.76-79. ⟨10.1111/j.1528-1167.2008.01842.x⟩
Epilepsia, 2008, 49, pp.76-79. ⟨10.1111/j.1528-1167.2008.01842.x⟩
Changes in the metabolism of polyunsaturated fatty acids (PUFA), both in children on the high fat ketogenic diet (KD) for seizure control and in rats on a KD enriched in PUFA, raise the possibility that increased brain arachidonic acid (ARA) and/or d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b051033153f304df7e162e256e2876
https://hal.archives-ouvertes.fr/hal-02310287
https://hal.archives-ouvertes.fr/hal-02310287
Autor:
Sébastien Tremblay, Roger Lecomte, Jacques Rousseau, Fabien Pifferi, M'hamed Bentourkia, Stephen C. Cunnane
Publikováno v:
AJP-Endocrinology and Metabolism
AJP-Endocrinology and Metabolism, American Physiological Society, 2009, 296 (4), pp.E796-E801. ⟨10.1152/ajpendo.90644.2008⟩
AJP-Endocrinology and Metabolism, 2009, 296 (4), pp.E796-E801. ⟨10.1152/ajpendo.90644.2008⟩
AJP-Endocrinology and Metabolism, American Physiological Society, 2009, 296 (4), pp.E796-E801. ⟨10.1152/ajpendo.90644.2008⟩
AJP-Endocrinology and Metabolism, 2009, 296 (4), pp.E796-E801. ⟨10.1152/ajpendo.90644.2008⟩
Normally, the brain's fuel is glucose, but during fasting it increasingly relies on ketones (β-hydroxybutyrate, acetoacetate, and acetone) produced in liver mitochondria from fatty acid β-oxidation. Although moderately raised blood ketones produced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ae723341634c452daf748be281e15a8
https://hal.archives-ouvertes.fr/hal-02310307
https://hal.archives-ouvertes.fr/hal-02310307
Autor:
Panman, J. L., Venkatraghavan, V., Van Der Ende, E. L., Steketee, R. M. E., Jiskoot, L. C., Poos, J. M., Dopper, E. G. P., Meeter, L. H. H., Kaat, L. D., Rombouts, S. A. R. B., Vernooij, M. W., Kievit, A. J. A., Premi, E., Cosseddu, M., Bonomi, E., Olives, J., Rohrer, J. D., Sanchez-Valle, R., Borroni, B., Bron, E. E., Van Swieten, J. C., Papma, J. M., Klein, S., Afonso, S., Almeida, M. R., Anderl-Straub, S., Andersson, C., Antonell, A., Archetti, S., Arighi, A., Balasa, M., Barandiaran, M., Bargallo, N., Bartha, R., Bender, B., Black, S., Butler, C., Bocchetta, M., Borrego-Ecija, S., Bras, J., Bruffaerts, R., Caroppo, P., Cash, D., Castelo-Branco, M., Convery, R., Cope, T., Danek, A., De Arriba, M., De Mendonca, A., Di Fede, G., Diaz, Z., Ducharme, S., Duro, D., Fenoglio, C., Ferreira, C. B., Finger, E., Flanagan, T., Fox, N., Freedman, M., Fumagalli, G., Gabilondo, A., Galimberti, D., Gasparotti, R., Gauthier, S., Gazzina, S., Gerhard, A., Giaccone, G., Gorostidi, A., Graff, C., Greaves, C., Guerreiro, R., Heller, C., Hoegen, T., Indakoetxea, B., Jelic, V., Karnath, H. -O., Keren, R., Laforce, R., Leitao, M. J., Levin, J., Llado, A., Loosli, S., Maruta, C., Masellis, M., Mead, S., Miltenberger, G., Van Minkelenm Sara Mitchell, R., Moore, K., Moreno, F., Nicholas, J., Oijerstedt, L., Otto, M., Ourselin, S., Padovani, A., Peakman, G., Pijnenburg, Y., Polito, C., Prioni, S., Prix, C., Rademakers, R., Redaelli, V., Rittman, T., Rogaeva, E., Rosa-Neto, P., Rossi, G., Rosser, M., Rowe, J., Santana, I., Santiago, B., Scarpini, E., Schonecker, S., Shafei, E. S. R., Shoesmith, C., Synofzik, M., Tabuas-Pereira, M., Tagliavini, F., Tartaglia, C., Tainta, M., Taipa, R., Tang-Wai, D., Thomas, D. L., Thonberg, H., Timberlake, C., Tiraboschi, P., Todd, E., Vandamme, P., Vandenberghe, R., Vandenbulcke, M., Veldsman, M., Verdelho, A., Villanua, J., Warren, J., Wilkeione, C., Elisabeth, W., Henrik, W., Zulaica, Z. M.
Publikováno v:
Journal of Neurology, Neurosurgery and Psychiatry
Panman, J L, Venkatraghavan, V, Van Der Ende, E L, Steketee, R M E, Jiskoot, L C, Poos, J M, Dopper, E G P, Meeter, L H H, Donker Kaat, L, Rombouts, S A R B, Vernooij, M W, Kievit, A J A, Premi, E, Cosseddu, M, Bonomi, E, Olives, J, Rohrer, J D, Sánchez-Valle, R, Borroni, B, Bron, E E, Van Swieten, J C, Papma, J M & Klein, S 2021, ' Modelling the cascade of biomarker changes in GRN-related frontotemporal dementia ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 92, no. 5, pp. 494-501 . https://doi.org/10.1136/jnnp-2020-323541
Journal of Neurology, Neurosurgery and Psychiatry, 92(5), 494-501. BMJ Publishing Group
Journal of Neurology, Neurosurgery and Psychiatry, 92(5), 494-501. BMJ PUBLISHING GROUP
Panman, J L, Venkatraghavan, V, Van Der Ende, E L, Steketee, R M E, Jiskoot, L C, Poos, J M, Dopper, E G P, Meeter, L H H, Donker Kaat, L, Rombouts, S A R B, Vernooij, M W, Kievit, A J A, Premi, E, Cosseddu, M, Bonomi, E, Olives, J, Rohrer, J D, Sánchez-Valle, R, Borroni, B, Bron, E E, Van Swieten, J C, Papma, J M & Klein, S 2021, ' Modelling the cascade of biomarker changes in GRN-related frontotemporal dementia ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 92, no. 5, pp. 494-501 . https://doi.org/10.1136/jnnp-2020-323541
Journal of Neurology, Neurosurgery and Psychiatry, 92(5), 494-501. BMJ Publishing Group
Journal of Neurology, Neurosurgery and Psychiatry, 92(5), 494-501. BMJ PUBLISHING GROUP
ObjectiveProgranulin-related frontotemporal dementia (FTD-GRN) is a fast progressive disease. Modelling the cascade of multimodal biomarker changes aids in understanding the aetiology of this disease and enables monitoring of individual mutation carr