Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Thomas F. Schilling"'
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 17, Iss 6, p e1009077 (2021)
PLoS computational biology, vol 17, iss 6
PLoS Computational Biology, Vol 17, Iss 6, p e1009077 (2021)
PLoS computational biology, vol 17, iss 6
The vertebrate hindbrain is segmented into rhombomeres (r) initially defined by distinct domains of gene expression. Previous studies have shown that noise-induced gene regulation and cell sorting are critical for the sharpening of rhombomere boundar
Publikováno v:
Dev Dyn
Background Endochondral ossification is a major bone forming mechanism in vertebrates, defects in which can result in skeletal dysplasia or craniofacial anomalies in humans. The zebrafish holds great potential to advance our understanding of endochon
Autor:
Lina Meinecke, Adam L. MacLean, David E. Clouthier, Qing Nie, Praveer P. Sharma, Thomas F. Schilling
Publikováno v:
Genesis (New York, N.Y. : 2000), vol 57, iss 1
The mandibular or first pharyngeal arch forms the upper and lower jaws in all gnathostomes. A gene regulatory network that defines ventral, intermediate, and dorsal domains along the dorsal-ventral (D-V) axis of the arch has emerged from studies in z
Publikováno v:
eLife, Vol 7 (2018)
eLife
eLife
Mechanical forces between cells and extracellular matrix (ECM) influence cell shape and function. Tendons are ECM-rich tissues connecting muscles with bones that bear extreme tensional force. Analysis of transgenic zebrafish expressing mCherry driven
Publikováno v:
Current Biology. 30:3277-3292.e5
The musculoskeletal system is a striking example of how cell identity and position is coordinated across multiple tissues to ensure function. However, it is unclear upon tissue loss, such as complete loss of cells of a central musculoskeletal connect
Autor:
Julian Sosnik, Enrico Gratton, Qing Nie, Christopher Rackauckas, Michelle A. Digman, Likun Zheng, Thomas F. Schilling
Publikováno v:
eLife
Sosnik, J; Zheng, L; Rackauckas, CV; Digman, M; Gratton, E; Nie, Q; et al.(2016). Noise modulation in retinoic acid signaling sharpens segmental boundaries of gene expression in the embryonic zebrafish hindbrain. ELIFE, 5, e14034. doi: 10.7554/eLife.14034. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8v88t9j4
eLife, Vol 5 (2016)
Sosnik, J; Zheng, L; Rackauckas, CV; Digman, M; Gratton, E; Nie, Q; et al.(2016). Noise modulation in retinoic acid signaling sharpens segmental boundaries of gene expression in the embryonic zebrafish hindbrain. ELIFE, 5, e14034. doi: 10.7554/eLife.14034. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/8v88t9j4
eLife, Vol 5 (2016)
Morphogen gradients induce sharply defined domains of gene expression in a concentration-dependent manner, yet how cells interpret these signals in the face of spatial and temporal noise remains unclear. Using fluorescence lifetime imaging microscopy
Publikováno v:
PLoS genetics, vol 10, iss 10
Le Pabic, P; Ng, C; & Schilling, TF. (2014). Fat-Dachsous Signaling Coordinates Cartilage Differentiation and Polarity during Craniofacial Development. PLoS Genetics, 10(10). doi: 10.1371/journal.pgen.1004726. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9s28c4js
PLoS Genetics
PLoS Genetics, Vol 10, Iss 10, p e1004726 (2014)
Le Pabic, P; Ng, C; & Schilling, TF. (2014). Fat-Dachsous Signaling Coordinates Cartilage Differentiation and Polarity during Craniofacial Development. PLoS Genetics, 10(10). doi: 10.1371/journal.pgen.1004726. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9s28c4js
PLoS Genetics
PLoS Genetics, Vol 10, Iss 10, p e1004726 (2014)
Organogenesis requires coordinated regulation of cellular differentiation and morphogenesis. Cartilage cells in the vertebrate skeleton form polarized stacks, which drive the elongation and shaping of skeletal primordia. Here we show that an atypical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab93caffa9520d85ee461d5453ccfee1
https://escholarship.org/uc/item/9s28c4js
https://escholarship.org/uc/item/9s28c4js
Autor:
Thomas F. Schilling, Arul Subramanian
Publikováno v:
Subramanian, A; & Schilling, TF. (2014). Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions. eLife, 2014(3). doi: 10.7554/eLife.02372. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/9w33f1v6
eLife, vol 3, iss 3
eLife, Vol 3 (2014)
eLife
eLife, vol 3, iss 3
eLife, Vol 3 (2014)
eLife
Tendons are extracellular matrix (ECM)-rich structures that mediate muscle attachments with the skeleton, but surprisingly little is known about molecular mechanisms of attachment. Individual myofibers and tenocytes in Drosophila interact through int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42f1dc1c5d4589928755a5e7bd741218
http://www.escholarship.org/uc/item/9w33f1v6
http://www.escholarship.org/uc/item/9w33f1v6
Publikováno v:
PLoS Biology
Tuttle, AM; Hoffman, TL; & Schilling, TF. (2014). Rabconnectin-3a Regulates Vesicle Endocytosis and Canonical Wnt Signaling in Zebrafish Neural Crest Migration. PLoS Biology, 12(5). doi: 10.1371/journal.pbio.1001852. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/99d4419f
PLoS Biology, Vol 12, Iss 5, p e1001852 (2014)
PLoS biology, vol 12, iss 5
Tuttle, AM; Hoffman, TL; & Schilling, TF. (2014). Rabconnectin-3a Regulates Vesicle Endocytosis and Canonical Wnt Signaling in Zebrafish Neural Crest Migration. PLoS Biology, 12(5). doi: 10.1371/journal.pbio.1001852. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/99d4419f
PLoS Biology, Vol 12, Iss 5, p e1001852 (2014)
PLoS biology, vol 12, iss 5
A novel role for Rabconnectin-3a in endosome maturation regulates Wnt signaling, migration, and fate specification in zebrafish neural crest cells.
Cell migration requires dynamic regulation of cell–cell signaling and cell adhesion. Both of th
Cell migration requires dynamic regulation of cell–cell signaling and cell adhesion. Both of th
Autor:
Carmen Sonntag, Wendy Chua, Tamar E. Sztal, Thomas E. Hall, Abigail Gibson, Mai E. Nguyen-Chi, Robert J. Bryson-Richardson, Thomas F. Schilling, Peter D. Currie
Publikováno v:
PLoS Genetics
PLoS Genetics, Public Library of Science, 2012, 8 (10), pp.e1003014. ⟨10.1371/journal.pgen.1003014⟩
PLoS Genetics, Vol 8, Iss 10, p e1003014 (2012)
PLoS Genetics, Public Library of Science, 2012, 8 (10), pp.e1003014. ⟨10.1371/journal.pgen.1003014⟩
PLoS Genetics, Vol 8, Iss 10, p e1003014 (2012)
One of the central questions of developmental biology is how cells of equivalent potential—an equivalence group—come to adopt specific cellular fates. In this study we have used a combination of live imaging, single cell lineage analyses, and per