Zobrazeno 1 - 10
of 93 775
pro vyhledávání: ''
Background: Three decades after the amyloid cascade hypothesis was first proposed, research into discovery of effective treatments for Alzheimer's disease has not yet produced any disease-modifying treatments. Aims: This review outlines the progress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab4092ff0feebaf6c66c3f6eddac0c5c
https://doi.org/10.12968/bjnn.2021.17.1.34
https://doi.org/10.12968/bjnn.2021.17.1.34
Autor:
Ricardo Giovannini, Giulia Poggi, Irina Adamcyzk, Christopher R. Pryce, Stefan Just, Diana Kúkeľová, Nagiua Cuomo-Haymour, Rene Amport, Hannes Sigrist
Publikováno v:
Biological Psychiatry Global Open Science. 2:470-479
Background Excessive processing of aversive life events is a major pathology in stress-related anxiety and depressive disorders. Current pharmacological treatments have rather non-specific mechanisms of action. Somatostatin is synthesized and release
Autor:
Xi Zhao, Gangcai Xie, Enkui Duan, Shitao Chen, Fei Sun, Xiaorong Wang, Zhichuan Chen, Shengnan Gong, Mengmeng Sang, Zhiran Li, Yingying Huang, Guishuan Wang
Publikováno v:
Genes & Diseases. 9:1062-1073
As a BET bromodomain inhibitor, JQ1 has been proven have efficacy against a number of different cancers. In terms of male reproduction, JQ1 may be used as a new type of contraceptive, since JQ1 treatment in male mice could lead to germ cell defects a
Autor:
Aniket Mishra, Tomáš Paus, Alexa S. Beiser, Sudha Seshadri, Ami Tsuchida, Christophe Tzourio, Hieab H.H. Adams, Stéphanie Debette, Fabrice Crivello, Bernard Mazoyer, Charles DeCarli, Quentin Le Grand, Joshua C. Bis, Melissa Macalli, Alexandre Laurent, Aicha Soumare, Baljeet Singh, Evan Fletcher, Muralidharan Sargurupremraj, Jean Shin, Claudia L. Satizabal, Mark Lathrop
Publikováno v:
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Elsevier, 2021, ⟨10.1016/j.bpsc.2021.10.011⟩
Biological psychiatry. Cognitive neuroscience and neuroimaging, vol 7, iss 6
Biol Psychiatry Cogn Neurosci Neuroimaging
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7(6), 616-628. Elsevier Inc.
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Elsevier, 2021, ⟨10.1016/j.bpsc.2021.10.011⟩
Biological psychiatry. Cognitive neuroscience and neuroimaging, vol 7, iss 6
Biol Psychiatry Cogn Neurosci Neuroimaging
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 7(6), 616-628. Elsevier Inc.
Background Subcortical brain structures play a key role in pathological processes of age-related neurodegenerative disorders. Mounting evidence also suggests that early-life factors may have an impact on the development of common late-life neurologic
Publikováno v:
Frontiers in Digital Health, Vol 3 (2021)
Frontiers in Digital Health
Frontiers in Digital Health
Heart rate variability (HRV) is the rate of variability between each heartbeat with respect to time. It is used to analyse the Autonomic Nervous System (ANS), a control system used to modulate the body's unconscious action such as cardiac function, r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e939c5d8e054a76a8ad00f4bba38ac77
https://doi.org/10.32920/22734353
https://doi.org/10.32920/22734353
Publikováno v:
Frontiers in Neurology
Frontiers in Neurology, Vol 12 (2021)
Frontiers in Neurology, Vol 12 (2021)
The electrographic hallmark of childhood absence epilepsy (CAE) and other idiopathic forms of epilepsy are 2.5–4 Hz spike and wave discharges (SWDs) originating from abnormal electrical oscillations of the cortico-thalamo-cortical network. SWDs are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ac9a305f0dc15174714849ddd1fc0f
Autor:
Kozo Kaibuchi, Masaki Sone, Yoshiya Kawaguchi, Shinichiro Taya, Yusuke Seto, Kentaro Ichijo, Shogo Aida, Tomoo Owa, Tomoki Nishioka, Mariko Yamashita, Mikio Hoshino, Satoshi Miyashita
Publikováno v:
EMBO J
During development, neural progenitors are in proliferative and immature states; however, the molecular machinery that cooperatively controls both states remains elusive. Here, we report that cyclin D1 (CCND1) directly regulates both proliferative an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d1bcf7b666b0b1d0234a2005dfebe1
https://europepmc.org/articles/PMC10106980/
https://europepmc.org/articles/PMC10106980/
Autor:
Allison E. Aiello, Grace A. Noppert, Jennifer Beam Dowd, Rebecca C. Stebbins, Yang Claire Yang, Amanda M. Simanek
Publikováno v:
Am J Epidemiol
Chronic infections and the subsequent immune response have recently been shown to be risk factors for cognitive decline and Alzheimer disease and related dementias (ADRD). While some studies have shown an association between cytomegalovirus (CMV), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaddc9c0c7ad31c8ab2faacea1b948a6
https://doi.org/10.1093/aje/kwaa238
https://doi.org/10.1093/aje/kwaa238
Autor:
Scott I. Vrieze, Gretchen R.B. Saunders, Seon-Kyeong Jang, Yu Jiang, Mengzhen Liu, Dajiang J. Liu
Publikováno v:
Psychol Med
BackgroundSubstance use occurs at a high rate in persons with a psychiatric disorder. Genetically informative studies have the potential to elucidate the etiology of these phenomena. Recent developments in genome-wide association studies (GWAS) allow
Autor:
Anders M. Dale, Amy J. Jak, Kristy Cuthbert, Michael C. Neale, Lisa T. Eyler, Carol E. Franz, William S. Kremen, Richard L. Hauger, Xin Tu, Richard Vandiver, McKenna E. Williams, Chandra A. Reynolds, Ole A. Andreassen, Daniel E. Gustavson, Jeremy A. Elman, Mark W. Logue, Matthew S. Panizzon, Michael J. Lyons, Nathan A. Gillespie, Christine Fennema-Notestine, Nathan Whitsel, Ruth E. McKenzie, Rosemary Toomey, Mark Sanderson-Cimino, Graham M L Eglit, Hillary L. Ditmars, Hong Xian
Publikováno v:
Psychol Med
Psychological medicine, vol 52, iss 14
Psychological medicine, vol 52, iss 14
BackgroundClarifying the relationship between depression symptoms and cardiometabolic and related health could clarify risk factors and treatment targets. The objective of this study was to assess whether depression symptoms in midlife are associated