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Autor:
Ricardo Giovannini, Giulia Poggi, Irina Adamcyzk, Christopher R. Pryce, Stefan Just, Diana Kúkeľová, Nagiua Cuomo-Haymour, Rene Amport, Hannes Sigrist
Publikováno v:
Biological Psychiatry Global Open Science. 2:470-479
Background Excessive processing of aversive life events is a major pathology in stress-related anxiety and depressive disorders. Current pharmacological treatments have rather non-specific mechanisms of action. Somatostatin is synthesized and release
Autor:
Xuetong Li, Xuan Li, Xueting Wu, Zixuan Wang, Cuiting Wang, Hongxia Zhou, Yuanhong Shan, Ning Xiao, Aihong Li, Jirong Huang, L. Chen
Publikováno v:
Genomics, Proteomics & Bioinformatics. 20:702-714
Genome-scale metabolomics analysis is increasingly used for pathway and function discovery in post-genomics era. The great potential offered by developed mass spectrometry (MS)-based technology has been hindered by the obstacle that only a small port
Autor:
Christer S. Ejsing, Sandra F Gallego, Anthony H. Futerman, Richard R. Sprenger, Ole N. Jensen, Nanna Albæk, Steffen Schmidt, Marie W. Lindholm, Charlotte Øverup, Yael Pewzner-Jung, Sergey Kovalchuk, Iris D. Zelnik
Publikováno v:
Mol Ther
Schmidt, S, Gallego, S F, Zelnik, I D, Kovalchuk, S, Albæk, N, Sprenger, R R, Øverup, C, Pewzner-Jung, Y, Futerman, A H, Lindholm, M W, Jensen, O N & Ejsing, C S 2022, ' Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death ', Molecular Therapy, vol. 30, no. 4, pp. 1661-1674 . https://doi.org/10.1016/j.ymthe.2021.08.021
Schmidt, S, Gallego, S F, Zelnik, I D, Kovalchuk, S, Albæk, N, Sprenger, R R, Øverup, C, Pewzner-Jung, Y, Futerman, A H, Lindholm, M W, Jensen, O N & Ejsing, C S 2022, ' Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death ', Molecular Therapy, vol. 30, no. 4, pp. 1661-1674 . https://doi.org/10.1016/j.ymthe.2021.08.021
Emerging clinical data show that three ceramide molecules, Cer d18:1/16:0, Cer d18:1/24:1, and Cer d18:1/24:0, are biomarkers of a fatal outcome in patients with cardiovascular disease. This finding raises basic questions about their metabolic origin
Autor:
Ju Zhang, Nan Ding, Cuidan Li, Xiangli Zhang, Chongye Guo, Xiaoyuan Jiang, Dandan Lu, Jing Fu, Li Yang, Yongliang Zhao, Fei Chen, Xinmiao Jia, Dongsheng Zhou, Zhe Yin, Liya Yue
Publikováno v:
Genomics, Proteomics & Bioinformatics. 20:418-434
Klebsiella pneumoniae (K. pneumoniae) is an important pathogen that can cause severe hospital- and community-acquired infections. To systematically investigate its methylation features, we determined the whole-genome sequences of 14 K. pneumoniae str
Autor:
Paul H. Goodwin, Nuria Morfin, Thu Huong Pham, Tiffany A. Fillier, Ernesto Guzman-Novoa, Raymond Thomas
Publikováno v:
Journal of Advanced Research. 37:75-89
Introduction Honey bees (Apis mellifera) play key roles in food production performing complex behaviors, like self-grooming to remove parasites. However, the lipids of their central nervous system have not been examined, even though they likely play
Autor:
Zhongzhen Cai, Qian Feng, B. Qing Tang, Xuemei Bai, Jie Teng, Mengmei Li, Yuming Chen, Lin Wang, Glen Rein, Yu Chen
Publikováno v:
EXPLORE. 18:205-209
Objective Mitochondria are considered a portal to receive, process and integrate external energy and information to maintain cellular homeostasis. We examined the effect of Chinese texts with positive and negative meaning on the growth and mitochondr
Publikováno v:
CNS spectrums. 27(1)
Dementia-related psychosis (DRP) is prevalent across dementias and typically manifests as delusions and/or hallucinations. The mechanisms underlying psychosis in dementia are unknown; however, neurobiological and pharmacological evidence has implicat
Publikováno v:
Vojnosanitetski pregled (2022) 79(6):613-618
The results of clinical trials suggest that resveratrol may exert some beneficial effects on human health. However, important questions such as the dose and length of a treatment that would make the most of resveratrol potential remain unsolved. It i
Autor:
Kshitiz Singh, Denis Furling, Sumitava Dastidar, Marinee Chuah, Thierry VandenDriessche, Debanjana Majumdar, Jaitip Tipanee, Arnaud F. Klein
Publikováno v:
Molecular Therapy
Molecular Therapy, Cell Press, 2021, 29 (11), ⟨10.1016/j.ymthe.2021.08.004⟩
Molecular Therapy, 2021, 29 (11), ⟨10.1016/j.ymthe.2021.08.004⟩
Molecular Therapy, Cell Press, 2021, 29 (11), ⟨10.1016/j.ymthe.2021.08.004⟩
Molecular Therapy, 2021, 29 (11), ⟨10.1016/j.ymthe.2021.08.004⟩
CTGrepeat expansion (CTGexp) is associated with aberrant alternate splicing that contributes to cardiac dysfunction in myotonic dystrophy type 1 (DM1). Excision of thisCTGexprepeat using CRISPR-Cas resulted in the disappearance of punctate ribonuclea
Publikováno v:
Journal of Neurochemistry. 161:112-128
Previously, results from studies investigating if brain palmitic acid (16:0; PAM) was maintained by either dietary uptake or lipogenesis de novo (DNL) varied. Here, we utilize naturally occurring carbon isotope ratios (13 C/12 C; δ13 C) to uncover t