Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sampsa Matikainen"'
Publikováno v:
Viruses
Viruses, Vol 13, Iss 2513, p 2513 (2021)
Viruses, Vol 13, Iss 2513, p 2513 (2021)
SARS-CoV-2 is a new type of coronavirus that has caused worldwide pandemic. The disease induced by SARS-CoV-2 is called COVID-19. A majority of people with COVID-19 have relatively mild respiratory symptoms. However, a small percentage of COVID-19 pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18391c731367bc64635d7bbd2cbf073
http://hdl.handle.net/10138/338802
http://hdl.handle.net/10138/338802
Autor:
Martina B. Lorey, Dan Nordström, Yan Chen, Kristiina Silventoinen, Jukka Parantainen, Ilona Kareinen, Kari K. Eklund, Sampsa Matikainen, Petri T. Kovanen, Katri Niemi, Katariina Öörni, T. Juutilainen, Vesa-Petteri Kouri, Katariina Nurmi
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 8, Pp n/a-n/a (2021)
Clinical & Translational Immunology
Clinical & Translational Immunology
Objectives The NLRP3 inflammasome plays a key role in arterial wall inflammation. In this study, we elucidated the role of serum lipoproteins in the regulation of NLRP3 inflammasome activation by serum amyloid A (SAA) and other inflammasome activator
Publikováno v:
The Journal of Cell Biology
Matikainen et al. preview work from Wozniak et al. that reveals that inflammasomes mediate sequence-specific miRNA loading into exosomes.
Inflammasomes are multiprotein complexes of the innate immune system. Their activation leads to robust secr
Inflammasomes are multiprotein complexes of the innate immune system. Their activation leads to robust secr
Autor:
Susanna Valanne, Tuula A. Nyman, Mika Rämet, Saara Aittomäki, Tapio Lehtinen, Marko Pesu, Sampsa Matikainen
Publikováno v:
The FASEB Journal. 31:4770-4782
Invading pathogens provoke robust innate immune responses in Dipteran insects, such as Drosophila melanogaster In a systemic bacterial infection, a humoral response is induced in the fat body. Gram-positive bacteria trigger the Toll signaling pathway
Gram-negative bacteria are associated with a wide spectrum of infectious diseases in humans. Inflammasomes are cytosolic protein complexes that are assembled when the cell encounters pathogens or other harmful agents. The non-canonical caspase-4/5 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fffac8d7db9646101176c3f89c98783
https://europepmc.org/articles/PMC5393394/
https://europepmc.org/articles/PMC5393394/
Publikováno v:
The Journal of Immunology. 180:1749-1757
During an innate immune response, macrophages recognize viruses by their pattern recognition receptors. In this study, we have studied the role of membrane-associated TLRs and cytoplasmic retinoic acid inducible gene-I (RIG-I)-like receptors (RLR) in
Autor:
Tuula A. Nyman, Elina Välimäki, Kari K. Eklund, Sampsa Matikainen, Katariina Nurmi, Juhani Virkanen, Karl E.O. Åkerman, Wojciech Cypryk, Pauli M. Turunen
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 197(8)
Extracellular ATP is an endogenous danger signal that is known to activate inflammatory responses in innate immune cells, including macrophages. Activated macrophages start to secrete proteins to induce an immune response, as well as to recruit other
Publikováno v:
The Journal of Immunology. 165:1933-1938
IL-18 is a proinflammatory cytokine that enhances innate and specific Th1 immune responses. During microbial infections, IL-18 is produced by activated macrophages. IL-18 exerts its effects in synergy with IFN-α or IL-12 to induce IFN-γ. Here we sh
Publikováno v:
Molecularcellular proteomics : MCP. 12(3)
Monosodium urate (MSU) is an endogenous danger signal that is crystallized from uric acid released from injured cells. MSU is known to activate inflammatory response in macrophages but the molecular mechanisms involved have remained uncharacterized.
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 186(5)
dsRNA is an important pathogen-associated molecular pattern that is primarily recognized by cytosolic pattern-recognition receptors of the innate-immune system during virus infection. This recognition results in the activation of inflammasome-associa