Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Adrian Cook"'
Autor:
Claire L Vale, Sylvie Chabaud, Matthew R. Sydes, Andrew Kneebone, Mahesh K. B. Parmar, Paul Sargos, Carol Fraser-Browne, Chris Brown, David Fisher, Adrian Cook, Silvia Forcat, Chris Parker, Maria Pearse, Pierre Richaud, Meryem Brihoum, Christopher D. Brawley, Igor Latorzeff, Jayne F. Tierney
Publikováno v:
The Lancet. 396:1422-1431
Summary Background It is unclear whether adjuvant or early salvage radiotherapy following radical prostatectomy is more appropriate for men who present with localised or locally advanced prostate cancer. We aimed to prospectively plan a systematic re
Autor:
Timothy J. Perren, Rosemary Lord, Jane Hook, Ian A. McNeish, Christopher J. Poole, Jonathan A. Ledermann, Helena M. Earl, Sarah P. Blagden, Adrian Cook, Jae Weon Kim, Graham Dark, Andrew R Clamp, Marcia Hall, Dearbhaile M. O'Donnell, Richard Kaplan, Ian R. White, Lesley Howells, Andrew Dean, Elizabeth C. James
Publikováno v:
Lancet Oncol
The Lancet. Oncology
The Lancet. Oncology
Summary Background The ICON8 study reported no significant improvement in progression-free survival (a primary endpoint) with weekly chemotherapy compared with standard 3-weekly treatment among patients with epithelial ovarian cancer. All ICON8 patie
Autor:
Hani Gabra, Dearbhaile M. O'Donnell, S. P. Stenning, Christopher Coyle, Jane Hook, Rosalind Glasspool, Graham Dark, Rachel Jones, Susana Banerjee, Jonathan A. Ledermann, Helena M. Earl, Andrew R Clamp, Adrian Cook, Marcia Hall, Timothy J. Perren, Sarah Williams, Rosemary Lord, Mahesh K. B. Parmar, Gosala S. Gopalakrishnan, Ann Marie Swart, Jae Weon Kim, Sudha Sundar, James D. Brenton, Elizabeth C. James, Raj Naik, Richard Kaplan, Iain A. McNeish, Andrew Dean, Sarah P. Blagden
Publikováno v:
Lancet (London, England)
Background:\ud Carboplatin and paclitaxel administered every 3 weeks is standard-of-care first-line chemotherapy for epithelial ovarian cancer. The Japanese JGOG3016 trial showed a significant improvement in progression-free and overall survival with
Autor:
Nigel Klein, A. Kekitiinwa, Andrew J. Prendergast, Annie Shonhai, Mutsa Bwakura-Dangarembizi, Chipo Berejena, A S Walker, Patricia Nahirya-Ntege, Moira J. Spyer, Alexander J. Szubert, Godfrey Pimundu, Adrian Cook, DM Gibb, Victor Musiime
Publikováno v:
AIDS. 33:1485-1490
Objectives: A proportion of HIV-infected children with advanced disease develop severe malnutrition soon after antiretroviral therapy (ART) initiation. We tested the hypothesis that systemic inflammation underlies the pathogenesis of severe malnutrit
Autor:
Adrian Cook, Alex Hoyle, Nicholas D. James, Christopher D. Brawley, Matthew R. Sydes, Noel W. Clarke, Silke Gillessen, J. Calvert, Gerhardt Attard, Adnan Ali, David P. Dearnaley, Malcolm David Mason, Aine M Haran, Hassan Douis, Claire Amos, Mahesh K. B. Parmar, Chris Parker
Publikováno v:
Ali, A, Hoyle, A, Haran, A, Brawley, C D, Cook, A, Amos, C, Calvert, J, Douis, H, Mason, M D, Dearnaley, D P, Attard, G, Gillessen Sommer, S, Parmar, M, Parker, C, Sydes, M R, James, N D & Clarke, N 2021, ' Association of Bone Metastatic Burden With Survival Benefit From Prostate Radiotherapy in Patients With Newly Diagnosed Metastatic Prostate Cancer A Secondary Analysis of a Randomized Clinical Trial ', JAMA oncology . https://doi.org/10.1001/jamaoncol.2020.7857
Importance Prostate radiotherapy (RT) improves survival in men with low-burden metastatic prostate cancer. However, owing to the dichotomized nature of metastatic burden criteria, it is not clear how this benefit varies with bone metastasis counts an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d29b8ec036335ac4a530ff10ac5d7b
https://research.manchester.ac.uk/en/publications/2900b072-8b82-4343-ac8b-2d78e8b14ad4
https://research.manchester.ac.uk/en/publications/2900b072-8b82-4343-ac8b-2d78e8b14ad4
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-8 (2020)
Trials
Trials
Background Safety data is required to be collected in all clinical trials and can be separated into two types of data, adverse events and serious adverse events. Often, these types of safety data are collected as two discrete data sets, where adverse
Autor:
Andrew R Clamp, Sharadah Essapen, Adrian Cook, Marcia Hall, Elizabeth C. James, Sarah Williams, Jonathan A. Ledermann, Kate Scatchard, Jae Weon Kim, Jonathan Krell, Abel Zachariah, Gordon C Jayson, Iain A. McNeish, Axel Walther, Anjana Anand, Rachel Jones, Sudha Sundar, Christine Parkinson, Jeff Summers, Robert D. Morgan, Dolores Gallardo-Rincón, Christopher J. Poole, Graham Dark, Rosemary Lord, Rosalind Glasspool, Michelle Lockley
Publikováno v:
The Lancet. Oncology. 22(2)
Summary Background Platinum-based neoadjuvant chemotherapy followed by delayed primary surgery (DPS) is an established strategy for women with newly diagnosed, advanced-stage epithelial ovarian cancer. Although this therapeutic approach has been vali
Autor:
Julien Péron, Michel Tod, Christophe Sajous, Adrian Cook, Gilles Freyer, Timothy J. Perren, Olivier Colomban, Alexandra Leary, Benoit You
Publikováno v:
JNCI Cancer Spectrum
Bevacizumab is approved as a maintenance treatment in first-line setting in advanced-stage III-IV ovarian cancers, because GOG-0218 and ICON-7 phase III trials demonstrated progression-free survival benefits. However, only the subgroup of patients wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c797afc88f0ce5d9462aa2626a5708
Autor:
Chee Goh, Peter Cooke, Anjali Zarkar, Holly Pickering, Noel W. Clarke, Julian Money-Kyrle, Henriette Lindberg, Wendy R. Parulekar, Klaus Brasso, Mahesh K. B. Parmar, Martin Andreas Røder, Jason F. Lester, S L Morris, Nicholas D. James, Amit Bahl, Rajendra Persad, William Cross, Stephanie Gibbs, Charles Catton, Henrik Jakobsen, Peter Ostler, Rakesh Raman, James M. Wilson, Ian Sayers, Matthew R. Sydes, Ramasamy Jaganathan, Heather Payne, Lisa Owen, Howard Kynaston, Joe M. O'Sullivan, Adrian Cook, Sandeep Gujral, Alvan Pope, Ben Eddy, Chris Parker, Matthew S. Simms, Juliette Anderson, Rick Popert, Prashant Patel, Alastair Henderson, David Bottomley, John P Logue, Peter Meidahl Petersen, Fred Saad, Kathryn Lees, Rohit Chahal, Catherine Heath, S.K. Sundaram
Publikováno v:
Lancet (London, England). 396(10260)
Summary Background The optimal timing of radiotherapy after radical prostatectomy for prostate cancer is uncertain. We aimed to compare the efficacy and safety of adjuvant radiotherapy versus an observation policy with salvage radiotherapy for prosta
Autor:
Ruth E Farmer, Rhian Daniel, Deborah Ford, Adrian Cook, Victor Musiime, Mutsa Bwakura-Dangarembizi, Diana M Gibb, Andrew J Prendergast, A Sarah Walker, ARROW trial team
Publikováno v:
PLoS ONE, Vol 15, Iss 7, p e0233877 (2020)
PLoS ONE
PLoS ONE
Background:The impact of nutritional supplements on weight gain in HIV-infected children on antiretroviral treatment (ART) remains uncertain. Starting supplements depends upon current weight-for-age or other acute malnutrition indicators, producing t