Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Kirsi Vaaralahti"'
Publikováno v:
European Journal of Endocrinology. 184:K11-K14
Objective The role of miRNA as endocrine regulators is emerging, and microRNA mir-30b has been reported to repress Mkrn3. However, the expression of miR-30b during male puberty has not been studied. Design and methods Circulating relative miR-30b exp
Autor:
Kirsi Vaaralahti, Anna-Pauliina Iivonen, Taneli Raivio, Venkatram Yellapragada, Virpi Sidoroff, Henrikki Almusa, Juho Kärkinen
Publikováno v:
European Journal of Endocrinology
Patients with deletions on chromosome 9q31.2 may exhibit delayed puberty, craniofacial phenotype including cleft lip/palate, and olfactory bulb hypoplasia. We report a patient with congenital HH with anosmia (Kallmann syndrome, KS) and a de novo 2.38
Publikováno v:
Endocrine Connections, Vol 8, Iss 5, Pp 506-509 (2019)
Endocrine Connections
Endocrine Connections
In approximately half of congenital hypogonadotropic hypogonadism (cHH) patients, the genetic cause remains unidentified. Since the lack of certain miRNAs in animal models has led to cHH, we sequenced human miRNAs predicted to regulate cHH-related ge
Autor:
Päivi J. Miettinen, Kirsi Vaaralahti, Janne T. Backman, H. Huopio, Jorma Toppari, Sirpa Tenhola, Tero Varimo, Raimo Voutilainen, Ella Kohva, Jenni Viinamäki, Taneli Raivio, Matti Hero
Publikováno v:
Human Reproduction (Oxford, England)
STUDY QUESTIONDoes treatment of constitutional delay of growth and puberty (CDGP) in boys with aromatase inhibitor letrozole (Lz) or conventional low-dose testosterone (T) have differing effects on developing seminiferous epithelium?SUMMARY ANSWERAnt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1768ab9cfa93b0482389b57313f14c
http://hdl.handle.net/10138/314417
http://hdl.handle.net/10138/314417
Autor:
Jorma Toppari, Ella Kohva, Päivi J. Miettinen, Taneli Raivio, Virpi Sidoroff, Matti Hero, Kirsi Vaaralahti, Hanna Huopio
Publikováno v:
Journal of the Endocrine Society
Context Recombinant human FSH (r-hFSH), given to prepubertal boys with hypogonadotropic hypogonadism (HH), may induce Sertoli cell proliferation and thereby increase sperm-producing capacity later in life. Objective To evaluate the effects of r-hFSH,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4c04eb780ff46733aff3e488075830
http://hdl.handle.net/10138/292439
http://hdl.handle.net/10138/292439
Publikováno v:
European Journal of Endocrinology. 174:785-790
ObjectiveMakorin ring finger protein 3 (MKRN3) gene restrains the hypothalamic–pituitary–gonadal axis. In girls, peripheral levels of MKRN3 decline prior to the onset of puberty. We described longitudinal changes in serum MKRN3 levels in boys bef
Autor:
Matti Hero, Anna-Pauliina Iivonen, Johanna Hietamäki, Johanna Känsäkoski, Kirsi Vaaralahti, Elina Holopainen, Päivi J. Miettinen, Taneli Raivio
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0188750 (2017)
PLoS ONE, Vol 12, Iss 11, p e0188750 (2017)
Biallelic, partial loss-of-function mutations in GNRHR cause a wide spectrum of reproductive phenotypes from constitutional delay of growth and puberty to complete congenital hypogonadotropic hypogonadism. We studied the frequency of GNRHR, FGFR1, TA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e230992421291f49ac9411dc4270013
http://hdl.handle.net/10138/229916
http://hdl.handle.net/10138/229916
Publikováno v:
Human reproduction (Oxford, England). 33(2)
Congenital hypogonadotropic hypogonadism (CHH), which can present with a defective sense of smell (Kallmann syndrome, KS), is a clinically and genetically heterogeneous disorder. Over 31 genes have been associated with CHH, but most of the patients s
Autor:
Matti Hero, Kirsi Vaaralahti, Eeva-Maria Laitinen, Johanna Tommiska, Taneli Raivio, Tero Varimo
Publikováno v:
Clinical Endocrinology. 82:122-126
OBJECTIVE In search of phenotypic cues that would allow early detection of Kallmann syndrome (KS), we evaluated the paediatric phenotypes in a series of females with KS. DESIGN, PATIENTS AND MEASUREMENTS In this retrospective cohort study, we investi
Autor:
Taneli Raivio, Sanna Stennabb, Antti Hakkarainen, Nina Lundbom, Niina Matikainen, Kirsi Vaaralahti, Marja-Riitta Taskinen
Publikováno v:
European Journal of Endocrinology. 166:487-492
BackgroundElevated levels of circulating fibroblast growth factor 21 (FGF21) are commonly encountered in type 2 diabetes, dyslipidemia, and non-alcoholic fatty liver disease, all of which share exaggerated postprandial lipemia as a common proatheroge