Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Denise D. Belsham"'
Publikováno v:
Neuroendocrinology. 111:678-695
Background: Bisphenol A (BPA) is a ubiquitous endocrine disrupting chemical and obesogen. Although limited evidence exists of the effects of BPA on hypothalamic agouti-related peptide (AgRP) levels, the mechanisms underlying these effects remain unkn
Autor:
Jennifer A Chalmers, Prasad S Dalvi, Neruja Loganathan, Emma K McIlwraith, Leigh Wellhauser, Anaies Nazarians-Armavil, Judith A Eversley, Haneesha Mohan, Priska Stahel, Satya Dash, Michael B Wheeler, Denise D Belsham
Publikováno v:
Endocrinology
MicroRNAs (miRNAs) expressed in the hypothalamus are capable of regulating energy balance and peripheral metabolism by inhibiting translation of target messenger RNAs (mRNAs). Hypothalamic insulin resistance is known to precede that in the periphery,
Publikováno v:
Cells, Vol 10, Iss 3120, p 3120 (2021)
Cells
Cells
The hypothalamus maintains whole-body homeostasis by integrating information from circulating hormones, nutrients and signaling molecules. Distinct neuronal subpopulations that express and secrete unique neuropeptides execute the individual functions
Publikováno v:
Molecular and Cellular Endocrinology. 485:54-60
GPR173 is a highly conserved G protein coupled receptor associated with the hypothalamic-pituitary-gonadal reproductive axis. It is expressed in the brain and ovaries, however considerable knowledge about its function remains unknown. One putative li
Publikováno v:
Molecular and Cellular Endocrinology. 479:12-19
Endocrine disrupting chemicals, such as bisphenol A (BPA), have been linked to obesity. However, the direct effect of BPA on the hypothalamic pro-opiomelanocortin (POMC) neurons, which regulate energy homeostasis, remains unexplored. We define the ef
Publikováno v:
Pharmacology & Therapeutics. 233:108033
Spexin is the most recently discovered member of the galanin/kisspeptin/spexin family of peptides. This 14-amino acid peptide is highly conserved and is implicated in homeostatic functions including, but not limited to, metabolism, energy homeostasis
Autor:
Denise D. Belsham, Prasad S. Dalvi
Publikováno v:
Journal of neuroendocrinologyREFERENCES. 33(4)
Subsequent to the discovery of insulin by Banting and Best in the Department of Physiology at the University of Toronto 100 years ago, the field of insulin signalling and action has grown at a remarkable pace. Yet, the recognition that insulin action
Publikováno v:
Endocrinology. 161(11)
Bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, interferes with reproduction and is also considered an obesogen. The neuropeptide Y (NPY) neurons of the hypothalamus control both food intake and reproduction and have emerged as potenti
Autor:
Erika K. Tse, Alexandre Martchenko, Denise D. Belsham, Neruja Loganathan, Matthew N. Clemenzi, Patricia L. Brubaker
Publikováno v:
Molecular and cellular endocrinology. 507
Western diets that are high in saturated fat and sugar disrupt circadian rhythms, induce weight gain, and lead to metabolic diseases including obesity. However, the mechanistic link between altered circadian rhythms and energy homeostasis remains poo
Autor:
Beatriz Piatezzi Siqueira, Letícia Martins Ignácio-Souza, Andressa Reginato, Adriana Souza Torsoni, Marcio Alberto Torsoni, Marciane Milanski, Mariana Portovedo, Hosana G. Rodrigues, Denise D. Belsham, Suleyma O. Costa, Hervé Le Stunff, Thaís de Fante, Josiane Érica Miyamoto
Publikováno v:
Journal of neuroendocrinologyREFERENCES. 32(10)
High-fat diet (HFD) feeding is deleterious to hypothalamic tissue, leading to inflammation and lipotoxicity, as well as contributing to central insulin resistance. Autophagy is a process that restores cellular homeostasis by degrading malfunctioning