Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Preclinical research"'
Autor:
Mitsuaki Isobe, Yasuhiro Maejima, Natsuko Tamura, Yusuke Ito, Shun Nakagama, Takeshi Kasama, Kenzo Hirao, Yuka Shiheido-Watanabe, Tetsuo Sasano
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Treatment with linagliptin, a DPP-4 inhibitor, alleviates not only EAM but also ICIM. • DPP-4 physically interacts with cathepsin G and enhances its activity. • Linagliptin promotes SerpinA3N activity, thereby
Highlights • Treatment with linagliptin, a DPP-4 inhibitor, alleviates not only EAM but also ICIM. • DPP-4 physically interacts with cathepsin G and enhances its activity. • Linagliptin promotes SerpinA3N activity, thereby
Autor:
Aloke V. Finn, Atsushi Sakamoto, Matthew Kutyna, Hiroyuki Jinnouchi, Laura Perkins, Liang Guo, Anne Cornelissen, Stephen D. Pacetti, Frank D. Kolodgie, Renu Virmani, Sho Torii, Qi Cheng, Syed Hossainy
Publikováno v:
EuroIntervention
BACKGROUND: The relative thrombogenicity and albumin adsorption and retention of different durable polymers used in coronary stents has not been tested. AIMS: This study sought to compare the thromboresistance and albumin binding capacity of differen
Autor:
Giorgio Menallo, Antonio D'Amore, Arianna Adamo, Garrett N. Coyan, Lindemberg M. Silveira-Filho, William R. Wagner, Samuel K. Luketich
Publikováno v:
JACC: Basic to Translational Science, Vol 6, Iss 5, Pp 447-463 (2021)
JACC: Basic to Translational Science
JACC: Basic to Translational Science
Visual Abstract
Highlights • A simple, biohybrid patch made of polymer (PECUU) and ECM, without cellular components, was able to induce positive remodeling features when applied over chronic infarcts with severely dilated hearts and high cardi
Highlights • A simple, biohybrid patch made of polymer (PECUU) and ECM, without cellular components, was able to induce positive remodeling features when applied over chronic infarcts with severely dilated hearts and high cardi
Autor:
Laura A. Wilsdon, Peter J. Psaltis, Stephen J. Nicholls, Christina A. Bursill, Paul Zimmet, Kaitlin R. Morrison, Alex Brown, Carmel Bilu, Noga Kronfeld-Schor, Joanne T.M. Tan, Victoria A. Nankivell
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports
Type 2 diabetes mellitus (T2DM) increases cardiac inflammation which promotes the development of cardiac fibrosis. We sought to determine the impact of circadian disruption on the induction of hyperglycaemia, inflammation and cardiac fibrosis. Method
Autor:
Norbert Frey, Lucie Carrier, Franziska Dierck, Frauke Senger, Gabriele Brunke, Christian Kuhn, Nesrin Schmiedel, Ashraf Yusuf Rangrez, Derk Frank, Susanne Hille, Rainer Will, Samuel Sossalla, Maja Menke, Thomas Eschenhagen, Renate Lüllmann-Rauch, Inga Schmidt, Pia Bünger, Claudia Mack
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • FYCO1, a component of the autophagic machinery, is highly expressed in the heart and a potent inducer of cardiomyocyte autophagy. • Loss of FYCO1 in vivo inhibits adaptation to starvation or biomechanical stress
Highlights • FYCO1, a component of the autophagic machinery, is highly expressed in the heart and a potent inducer of cardiomyocyte autophagy. • Loss of FYCO1 in vivo inhibits adaptation to starvation or biomechanical stress
Autor:
Raymond M. Wang, Roberto Gaetani, Ryan C. Hill, Karen L. Christman, Kirk C. Hansen, Anthony N. DeMaria, Colin Luo, BS Miranda D. Diaz, Elaine Tran, Martin T. Spang, Rebecca L. Braden
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Myocardial matrix hydrogel preserves LV volumes and apical wall thickening in a chronic MI model. • Myocardial matrix hydrogel trends toward reduced fibrosis. • In vivo differential gene expression analysis sho
Highlights • Myocardial matrix hydrogel preserves LV volumes and apical wall thickening in a chronic MI model. • Myocardial matrix hydrogel trends toward reduced fibrosis. • In vivo differential gene expression analysis sho
Autor:
Ryota Tabei, Yujiro Kawai, Kazuaki Nakajima, Satoshi Kunita, Shota Someya, Jun Fujita, Hidenori Tani, Keiichi Fukuda, Yoshikazu Kishino, Hideaki Kanazawa, Shugo Tohyama, Takumi Teratani, Akira Ito, Noriko Handa, Akinori Hirano, Rei Shibata, Sho Tanosaki, Eiji Kobayashi, Shuji Hishikawa, Marina Okada, Hideyuki Shimizu, Masataka Yamazaki, Shigeo Okuda, Yoshitake Yamada, Yusuke Soma, Yasuhiko Tabata, Yuika Morita, Shinji Kawaguchi, Toyoaki Murohara
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • hiPSCs are differentiated into CMs with large-scale 2-dimensional culture system, and refined by metabolic purification. • hiPSC-derived CMs are developed into CSs in special microwell plates. • Intramyocardial
Highlights • hiPSCs are differentiated into CMs with large-scale 2-dimensional culture system, and refined by metabolic purification. • hiPSC-derived CMs are developed into CSs in special microwell plates. • Intramyocardial
Autor:
Nicola Potere, Aldo Bonaventura, Antonio Abbate, Alessandra Vecchié, Salvatore Carbone, Gianfranco Sinagra, Fabrizio Montecucco, Eleonora Mezzaroma, Antonio Cannatà, Rossana Bussani, John F. Paolini, Stefano Toldo, Pratyush Narayan, Benjamin W. Van Tassel, Adolfo G Mauro
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Acute pericarditis is characterized by an intense inflammatory response involving the pericardium. Although mostly benign in its clinical course, 30% of patients may experience complications (recurrence, treatment
Highlights • Acute pericarditis is characterized by an intense inflammatory response involving the pericardium. Although mostly benign in its clinical course, 30% of patients may experience complications (recurrence, treatment
Autor:
Danielle E. Soranno, Brysen Keith, DO Katja M. Gist, Kathy Ding, Rushita A. Bagchi, Timothy A. McKinsey, BS Sara A. Wennersten, John R. Montford, BS Lara Kirkbride-Romeo, BA Christopher Altmann, Korey R. Haefner, Sarah Faubel, Peter R. Baker, Maria A. Cavasin, Christian Steinkühler
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • This is the first long-term (1-year) study to evaluate both the kidney and systemic sequelae of acute kidney injury in mice. • Serial kidney function was measured via transcutaneous glomerular filtration rate.
Highlights • This is the first long-term (1-year) study to evaluate both the kidney and systemic sequelae of acute kidney injury in mice. • Serial kidney function was measured via transcutaneous glomerular filtration rate.
Autor:
Guangbin Shi, Yang Zhao, Shanna Hamilton, Man Liu, Feng Feng, Hong Liu, Radmila Terentyeva, Samuel C. Dudley, Dmitry Terentyev, An Xie, Bum-Rak Choi, Tae Yun Kim
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Diabetes-induced arrhythmic risk involved activation of innate immunity, elevation of IL-1β, mitochondrial oxidative stress, SR calcium release channel oxidation, and QT prolongation. • Diabetes-induced arrhythm
Highlights • Diabetes-induced arrhythmic risk involved activation of innate immunity, elevation of IL-1β, mitochondrial oxidative stress, SR calcium release channel oxidation, and QT prolongation. • Diabetes-induced arrhythm