Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Leslie A. Lange"'
Autor:
James G. Wilson, Jessica R Shaw, Paul L. Auer, Ake T. Lu, Neil A. Zakai, Mary Cushman, Steve Horvath, Kelsey Grinde, Mindy D. Szeto, Leslie A. Lange, Deborah A. Nickerson, Marsha M. Wheeler, Laura M. Raffield, Amarise Little, Alexander P. Reiner, Marguerite R. Irvin, Ethan M. Lange, Timothy A. Thornton
Publikováno v:
J Thromb Haemost
Background Prospective studies have suggested higher factor VIII (FVIII) levels are an independent risk factor for coronary heart disease (CHD) and stroke. However, limited information, including on genetic and epigenetic contributors to FVIII variat
Autor:
David J. Stott, Christopher J. O'Donnell, Nuno R. Zilhão, Eric A. Whitsel, Fangui Sun, Leslie A. Lange, Xiuqing Guo, Kerri L. Wiggins, Hanfei Xu, Aishwarya Sundaresan, Dennis O. Mook-Kanamori, Christy L. Avery, Albert V. Smith, Xiaohui Li, Til Stürmer, Ayush Giri, Raymond Noordam, Joshua C. Bis, Walter Palmas, Adolfo Correa, Laura M. Raffield, Peter Rossing, Rikki M. Tanner, Tarunveer S. Ahluwalia, James A. Stewart, Helen R. Warren, Jie Yao, Colleen M. Sitlani, Vilmundur Gudnason, Adrienne Cupples, James S. Floyd, Bruce M. Psaty, Jerome I. Rotter, Marguerite R. Irvin, Jacklyn N. Hellwege, Donna K. Arnett, Adriana M. Hung, Ching-Ti Liu, Nita A. Limdi, Stella Trompet, Todd L. Edwards, Lenore J. Launer, J. Wouter Jukema, Ian Ford
Publikováno v:
Am J Hypertens
American Journal of Hypertension, 32(12), 1146-1153. OXFORD UNIV PRESS
American journal of hypertension, vol 32, iss 12
American Journal of Hypertension, 32(12), 1146-1153. OXFORD UNIV PRESS
American journal of hypertension, vol 32, iss 12
BACKGROUND Only a handful of genetic discovery efforts in apparent treatment-resistant hypertension (aTRH) have been described. METHODS We conducted a case–control genome-wide association study of aTRH among persons treated for hypertension, using
Autor:
Stefan Weiss, Gauti Kjartan Gislason, Matthew J. Budoff, Valborg Gudmundsdottir, Xiuqing Guo, Lawrence F. Bielak, Joshua C. Bis, Jie Yao, Latchezar Dimitrov, Leslie A. Lange, Patricia A. Peyser, Lingyi Lu, Vilmundur Gudnason, Jerome I. Rotter, Barry I. Freedman, Lihua Wang, M. Arfan Ikram, Mohsen Ghanbari, Yingchang Lu, Jiaxi Zhu, Elias F Gudmundsson, Gerardo Heiss, Yi-Ping Fu, Maryam Kavousi, Shih-Jen Hwang, Sharon L.R. Kardia, Laura M. Raffield, André G. Uitterlinden, Carl D. Langefeld, Donald W. Bowden, Ping An, Daniel Bos, Kent D. Taylor, Ulf Schminke, Albert V. Smith, Bruce M. Psaty, James G. Wilson, Shyh-Huei Chen, Maggie C.Y. Ng, Christopher J. O'Donnell, Mary F. Feitosa, Nora Franceschini
Publikováno v:
Circ Genom Precis Med
Circulation: Genomic and Precision Medicine, 14(4):E003258. Lippincott Williams & Wilkins
Circulation. Genomic and precision medicine, vol 14, iss 4
Circulation: Genomic and Precision Medicine, 14(4):E003258. Lippincott Williams & Wilkins
Circulation. Genomic and precision medicine, vol 14, iss 4
Background: Coronary artery calcification (CAC) and carotid artery intima-media thickness (cIMT) are measures of subclinical atherosclerosis in asymptomatic individuals and strong risk factors for cardiovascular disease. Type 2 diabetes (T2D) is an i
Autor:
Kendra Ferrier, Laura M. Raffield, Mindy D. Szeto, Paul L. Auer, Jonathan A. Shortt, Colton Leavitt, Leslie A. Lange, Nels C. Olson, Maggie A. Stanislawski, Alexander P. Reiner, Mariah Meyer, Russell P. Tracy, Timothy A. Thornton, Ethan M. Lange, Neil A. Zakai
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: sCD14 (soluble CD14) is a circulating pattern recognition receptor involved in inflammatory signaling. Although it is known that sCD14 levels vary by race, information on the genetic and cardiovascular disease (CVD) risk relationships of s
Autor:
Ethan M. Lange, George Howard, Mary Cushman, Daniel R. Douce, Rakhi P. Naik, Cheryl A. Winkler, Elsayed Z. Soliman, Hyacinth I. Hyacinth, Leslie A. Lange, Marguerite R. Irvin, Neil A. Zakai
Publikováno v:
J Electrocardiol
Background Sickle cell trait (SCT), sickle cell disease's (SCD) carrier status, has been recently associated with worse cardiovascular and renal outcomes. An increased prevalence of atrial fibrillation (AF) is documented in SCD patients; however, stu
Autor:
Ma Elena Gonzalez, Marit E. Jørgensen, Edmund Chan, Eric Boerwinkle, Craig L. Hanis, Tim M. Strom, Young-Jin Kim, Alanna C. Morrison, Abigail Sveden, Zachary Zappala, Jianjun Liu, Markku Laakso, Russell P. Tracy, Andrew D. Morris, Farook Thameem, Ruth J. F. Loos, Robert Sladek, Moriel Singer-Berk, Jason Flannick, Stephen S. Rich, Angélica Martínez-Hernández, Rob M. van Dam, Wendy S. Post, Michael Boehnke, Peter M. Nilsson, Humberto García-Ortiz, Clicerio González-Villalpando, Samantha Baxter, Yoon Shin Cho, Sergio Islas-Andrade, Colin N. A. Palmer, Claudia H. T. Tam, Nicholas A. Watts, Lizz Caulkins, Rachel Son, Daniel G. MacArthur, Toni I. Pollin, Juan Manuel Malacara Hernandez, Jong-Young Lee, Bruce M. Psaty, Ravindranath Duggirala, Erwin P. Bottinger, Nancy L. Heard-Costa, Donna M. Lehman, Carlos A. Aguilar-Salinas, Juyoung Lee, Haichen Zhang, Mark I. McCarthy, Brian Tomlinson, Leslie A. Lange, Cecilia Contreras-Cubas, Johanna Kuusisto, Danish Saleheen, Juliana C.N. Chan, Andrew Dahl, Konstantin Strauch, Noël P. Burtt, Tien Yin Wong, Niels Grarup, Jerome I. Rotter, Ronald C.W. Ma, Julia K. Goodrich, Anne H. O’Donnell-Luria, Jose C. Florez, Miriam S. Udler-Aubrey, Kristin A. Maloney, James G. Wilson, Ramachandran S. Vasan, Bong-Jo Kim, Leif Groop, Noah Zaitlen, Kerrin S. Small, Heikki A. Koistinen, Donald W. Bowden, Wing-Yee So, Jaakko Tuomilehto, Oluf Pedersen, John C. Chambers, Mi Yeong Hwang, Karen L. Mohlke, John Blangero, Eleina M. England, Elvia Mendoza-Caamal, James B. Meigs, Federico Centeno-Cruz, Michael Preuss, Ralph A. DeFronzo, Joanne B. Cole, Jordan Wood, Allan Linneberg, Benjamin Glaser, Lorena Orozco, Jaspal S. Kooner, Valeriya Lyssenko, Sohee Han, Gil Atzmon, Ma. Eugenia Garay-Sevilla, Tiinamaija Tuomi, Brian E. Henderson, Christopher J. O'Donnell, Hyun Min Kang, Teresa Tusié-Luna, Nir Barzilai, Thomas Meitinger, Christian Gieger, Ben Weisburd, Alexander P. Reiner, Tim D. Spector, Myron D. Gross, E. Shyong Tai, Yik Ying Teo, for Amp-T D-Genes Consortia, Xueling Sim, Emilio J. Cordova, Cristina Revilla-Monsalve, Daniel R. Witte, Francisco Barajas-Olmos, Claudia Schurmann, Lori L. Bonnycastle, Josep M. Mercader, Adolfo Correa, Torben Hansen, Kyong Soo Park, Ching-Yu Cheng, Soo Heon Kwak, Nathalie Chami, Christopher A. Haiman, Xavier Soberón, Josée Dupuis, Maggie C.Y. Ng
Hundreds of thousands of genetic variants have been reported to cause severe monogenic diseases, but the probability that a variant carrier will develop the disease (termed penetrance) is unknown for virtually all of them. Additionally, the clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b370e73f991465e813905c8d7d43205e
https://doi.org/10.1101/2020.09.22.20195529
https://doi.org/10.1101/2020.09.22.20195529
Autor:
Paul L. Auer, Russell P. Tracy, Colton Leavitt, Neil A. Zakai, Nels C. Olson, Mary Cushman, Timothy A. Thornton, James G. Wilson, Ethan M. Lange, Laura M. Raffield, Alexander P. Reiner, Emily B. Levitan, Leslie A. Lange
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 4, p e0231013 (2020)
PLoS ONE, Vol 15, Iss 4, p e0231013 (2020)
Biomarkers of chronic inflammation (such as C-reactive protein) have long been associated with cardiovascular disease and mortality; however, biomarkers involved in antiviral cytokine induction and adaptive immune system activation remain largely une
Autor:
Dwight J. Klemm, Ethan M. Lange, Mindy D. Szeto, Deborah A. Nickerson, Alexander P. Reiner, Neil A. Zakai, Ivana V. Yang, Adolfo Correa, Laura M. Raffield, Leslie A. Lange, Matthew R.G. Taylor
Publikováno v:
Circulation. 141
Cardiovascular disease (CVD) is the leading cause of death in the U.S. and disproportionately affects African Americans (AAs). Routinely measured circulating red blood cell traits, which are highly heritable and differ by ethnicity, are independent p
Autor:
Cashell E. Jaquish, Craig P. Hersh, Emily Barron-Casella, Larry Phillips, James S. Pankow, JoAnn E. Manson, Mariza de Andrade, Vivien A. Sheehan, Norann A. Zaghloul, Yongmei Liu, Sergei Nekhai, Russell P. Tracy, Bruce S. Weir, Pankaj Qasba, Adrienne M. Stilp, Tasha E. Fingerlin, Heather M. Ochs-Balcom, L. Adrienne Cupples, Rongze Yang, David A. Schwartz, Shannon Kelly, Scott E. Devine, Tanja Smith, G.L. Kinney, Beverly Snively, Kent D. Taylor, Manolis Kellis, Ruth J. F. Loos, Seth A. Ament, Kathleen C. Barnes, Robert C. Kaplan, Ulrich Broeckel, Hemant K. Tiwari, Karin F. Hoth, Peter Durda, Julie L. Mikulla, Charles B. Eaton, Cotton Seed, Merry Lynn McDonald, Eric Boerwinkle, Josh Smith, Honghuang Lin, Ingrid B. Borecki, Jeffrey L. Curtis, Emelia J. Benjamin, Kenneth Rice, Sharon L.R. Kardia, Nicholas L. Smith, Coleen M. Damcott, Jeffrey Haessler, Kimberly L. Jones, Elaine Cornell, Nona Sotoodehnia, Adolfo Correa, Rich Johnston, C. Charles Gu, Chii Min Hwu, Peter C. Anderson, Lesley F. Tinker, Colleen Davis, R. Graham Barr, Scott T. Weiss, Leanna Farnam, Chao Hsiung, Brian Silver, Patrick F. McArdle, Lisa W. Martin, Yii-Der Ida Chen, John Barnard, Holly Kramer, Sekar Kathiresan, Gonçalo R. Abecasis, Barry Make, Michael C. Mahaney, Marco V Perez, Donna K. Arnett, Mark Chaffin, Xiuqing Guo, Joshua C. Bis, Pamela Russell, Paul L. Auer, James G. Wilson, Marilyn J. Telen, David K. Levine, Jennifer A. Smith, Christopher Scheller, Meher Preethi Boorgula, Aakrosh Ratan, Kari E. North, Dan E. Arking, Elizabeth A. Regan, Margaret G. Parker, Andres Metspalu, Jai G. Broome, Daniel Taliun, Lynette Ekunwe, Alyna T. Khan, Hao Mei, Dhananjay Vaidya, Ellen M. Schmidt, Stanford Mwasongwe, Joshua P. Lewis, Stacey Gabriel, Christine E. Seidman, Margery Gass, Deborah A. Nickerson, Nicola L. Hawley, Rebecca L. Beer, Afshin Parsa, Steven L. Salzberg, Terri H. Beaty, Stella Aslibekyan, Girish N. Nadkarni, Wei Zhao, David L. Tirschwell, Karen Bunting, Dawn L. DeMeo, Laura J. Rasmussen-Torvik, Julia Powers Becker, Dmitry Prokopenko, Karen Schwander, Bruce D. Gelb, Stephanie Krauter, Laura M. Raffield, Michael E. Hall, Frank C. Sciurba, Lauren Margolin, Nora Franceschini, Daniel N. Harris, Seyedeh M. Zekavat, Dawood Darbar, Keng-Han Lin, Haley Huston, Steven A. Lubitz, Andrea Ganna, Carole Sztalryd, Cathy C. Laurie, Christy Chang, James E. Hixson, Steven A. McCarroll, Barbara A. Konkle, Michael D. Kessler, Scott I. Vrieze, Yingze Zhang, Sarah Ruuska, George J. Papanicolaou, Weiniu Gan, Maris Alver, Elizabeth A. Streeten, Fei Fei Wang, Lu-Chen Weng, Braxton D. Mitchell, Lee-Ming Chuang, Sean P. David, Wei-Min Chen, Susan R. Heckbert, Ryan D. Hernandez, Andrew D. Johnson, Cristen J. Willer, Ani Manichaikul, Jonathan M. Bloom, Timothy D. O’Connor, Sylvia Smoller, Marguerite R. Irvin, Seung Hoan Choi, Ida Surakka, Veikko Salomaa, Diane M. Becker, Ron Do, W. Craig Johnson, Cecelia A. Laurie, Meryl S. LeBoff, Aniket Shetty, Tõnu Esko, Michael C. Zody, Xiaoqi Geng, Da Wei Gong, Snow Xueyan Zhao, Esteban G. Burchard, Xiuwen Zheng, Cara L. Carty, Alexander P. Reiner, Tim Assimes, Deborah A. Meyers, Mina K. Chung, Harald H H Göring, Benjamin M. Neale, Pradeep Natarajan, Yan Gao, Stephen S. Rich, Yun Ju Sung, Susan K. Dutcher, Ferdouse Begum, Stephanie M. Gogarten, John Blangero, Jonathan Cardwell, Kayleen Williams, Rakhi P. Naik, Amol C. Shetty, Sayantan Das, Myriam Fornage, May E. Montasser, Michelle Daya, Edwin K. Silverman, Daniel E. Weeks, Laura J. Kaufman, Dimitrios Avramopoulos, Michael Y. Tsai, Christine M. Albert, Vijay G. Sankaran, Jeffrey R. O'Connell, Thomas W. Blackwell, Stephen T. McGarvey, Robert M. Reed, Leslie A. Lange, Qing Duan, Bruce M. Psaty, Leslie S. Emery, Bertha Hidalgo, Jennifer A. Brody, L. Keoki Williams, Soren Germer, Zhaohui S. Qin, Deepti Jain, Deborah Applebaum-Bowden, Carla Wilson, Degui Zhi, Christoph Lange, Elliott Hong, L.F. Bielak, Wen Jane Lee, Yue Guan, Tarik Walker, Rebecca D. Jackson, Charles R. Farber, Mark J. Daly, Stephanie M. Fullerton, John E. Hokanson, Karol E. Watson, James Luo, Richard Casaburi, Seunggeun Lee, Jill M. Johnsen, Margaret A. Taub, Ryan L. Minster, Ravi Duggirala, Susan K. Mathai, Yun Li, Quenna Wong, Matthew Flickinger, Huichun Xu, Susan Redline, Ulrike Peters, Ivana V. Yang, Jesse M. Engreitz, Sanni Ruotsalainen, Sean K. McFarland, Avram D Walts, Patricia A. Peyser, Allison E. Ashley-Koch, Lewis C. Becker, Nicholette Palmer Allred, James A. Perry, Jody S. Sylvia, Tamar Sofer, Vasan S. Ramachandran, Laura Almasy, Matthew J. Budoff, Ranjan Deka, David M. Herrington, Simeon I. Taylor, Daniel Levy, Chaojie Yang, Sameer Chavan, Kathleen A. Ryan, Josyf C. Mychaleckyj, Ingo Ruczinski, Sebastian Zoellner, Michael Preuss, Tim Poterba, Wendy S. Post, Amber L. Beitelshees, Ben Heavner, Carolina Roselli, Namiko Abe, Jonathon LeFaive, Mark T. Gladwin, Brian Custer, Robert B. Wallace, Simin Liu, Michael H. Cho, Robert E. Handsaker, Dabeeru C. Rao, Bo Juen Chen, Wayne Hui Heng Sheu, Xiang Zhou, Marcos Bezerra, Solomon K. Musani, Eimear E. Kenny, James F. Casella, Kathryn L. Lunetta, Nancy Min, Nicholas Rafaels, Lisa R. Yanek, Min A. Jhun, David C. Glahn, Rasika A. Mathias, Mollie A. Minear, Russell P. Bowler, Jason Ernst, Carolyn J. Crandall, Sara Penchev, Alvaro Alonso, Timothy A. Thornton, Toni I. Pollin, Charles Kooperberg, Ethan M. Lange, Juan M. Peralta, Pramod Anugu, Lucinda Fulton, Adam A. Szpiro, Michael R. DeBaun, M. Benjamin Shoemaker, Sam Phillips, Dan M. Roden, Mao Fu, Daniel I. Chasman, James D. Crapo, Hua Tang, Gina M. Peloso, Hyun Min Kang, Samuli Ripatti, Phuwanat Sakornsakolpat, Christopher R. Gignoux, Peter VandeHaar, Jerome I. Rotter, Dandi Qiao, Emily S. Wan, Shabnam Salimi, Kevin Sandow, Jiang He, Patrick T. Ellinor, Joanne E. Curran
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature communications, vol 9, iss 1
Nature Communications
Nature communications, vol 9, iss 1
Nature Communications
Lipoprotein(a), Lp(a), is a modified low-density lipoprotein particle that contains apolipoprotein(a), encoded by LPA, and is a highly heritable, causal risk factor for cardiovascular diseases that varies in concentrations across ancestries. Here, we
Autor:
Molly M. Shores, Leslie A. Lange, Kenneth J. Mukamal, Richard A. Kronmal, Michael A. Rosenberg, Alvin M. Matsumoto, Petra Bůžková, Susan R. Heckbert
Publikováno v:
Clinical Cardiology. 41:830-836
BACKGROUND: Decline in serum androgens is common among older men and has been associated with cardiovascular disease, although its role in risk of atrial fibrillation (AF) has not been well defined. HYPOTHESIS: Low serum androgens are associated with