Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Preclinical research"'
Autor:
Guangbin Shi, Yang Zhao, Shanna Hamilton, Man Liu, Feng Feng, Hong Liu, Radmila Terentyeva, Samuel C. Dudley, Dmitry Terentyev, An Xie, Bum-Rak Choi, Tae Yun Kim
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Diabetes-induced arrhythmic risk involved activation of innate immunity, elevation of IL-1β, mitochondrial oxidative stress, SR calcium release channel oxidation, and QT prolongation. • Diabetes-induced arrhythm
Highlights • Diabetes-induced arrhythmic risk involved activation of innate immunity, elevation of IL-1β, mitochondrial oxidative stress, SR calcium release channel oxidation, and QT prolongation. • Diabetes-induced arrhythm
Autor:
Emiliano Votta, Riccardo Vismara, Federico Lucherini, Gianfranco Beniamino Fiore, Eleonora Salurso, Edoardo Maroncelli, Carlo Antona, Andrea Mangini, Rubina Rosa, Michal Jaworek
Publikováno v:
Journal of Cardiovascular Translational Research
Transcatheter therapies are emerging for functional mitral regurgitation (FMR) treatment, however there is lack of pathological models for their preclinical assessment. We investigated the applicability of deer hearts for this purpose. 8 whole deer h
Autor:
Sang-Hyun Lee, Yonghyun Won, Markus Reinthaler, Jeong Su Kim, Min Soo Cho, Seung-Whan Lee, Eun-Seok Shin, Jai-Wun Park, Robert J. Lederman, June-Hong Kim, Soo-Yong Lee, Min-Ku Chon, Gi-Byung Nam, Eun Jung Jun, Donghun Shin, Yong-Hyun Park
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Surgical myectomy is morbid and transcoronary alcohol septal ablation can result in geographic miss or occasional nontarget injury. • We developed a transvenous intraseptal radiofrequency ablation technique (cerc
Highlights • Surgical myectomy is morbid and transcoronary alcohol septal ablation can result in geographic miss or occasional nontarget injury. • We developed a transvenous intraseptal radiofrequency ablation technique (cerc
Autor:
Hoda Hatoum, Jason Zakko, Stacey Carey, Joseph D. Drews, Lakshmi Prasad Dasi, Christopher K. Breuer, Aimee K. Armstrong, Olivia Conroy, Megan Heitkemper, John Kelly, Karen Texter, Martin L. Bocks, Kevin M. Blum, Madeleine D. Russell, Shelley Gooden, Ellie Ragsdale, Yen-Lin Wu, Michael S. Sacks, Yadong Wang, James Strainic
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • A fully biodegradable fetal valve was developed using a zinc-aluminum alloy stent and electrospun PCL leaflets. • In vitro evaluation of the valve was performed with accelerated degradation, mechanical, and flow
Highlights • A fully biodegradable fetal valve was developed using a zinc-aluminum alloy stent and electrospun PCL leaflets. • In vitro evaluation of the valve was performed with accelerated degradation, mechanical, and flow
Autor:
Sascha Halvachizadeh, Volkmar Falk, Thea Fleischmann, Miriam Lipiski, Francesco Maisano, Beate Kolb, Matthias Eberhard, Mareike Sauer, Nikola Cesarovic, Maximilian Y. Emmert, Hatem Alkadhi
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports, 10 (1)
Scientific Reports
Scientific Reports, 10 (1)
Scientific Reports
The pig (Sus Scrofa Domestica) is an accepted model for preclinical evaluation of prosthetic heart valves and trans-catheter implantation techniques. Understanding porcine cardiac dimensions through three-dimensional computed tomography (CT), increas
Autor:
Seimi Satomi-Kobayashi, Ken-ichi Hirata, Yasuhiro Irino, Ryuji Toh, Tatsuro Ishida, Tetsuya Hara, Makoto Nishimori, Farouc A. Jaffer, Masakazu Shinohara, Mitsumasa Okano
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • We established a novel clinically relevant murine DVT model at femoral/saphenous vein induced by flow restriction and light illumination. • Our model newly succeeded in inducing DVT in a valve pocket and enabled
Highlights • We established a novel clinically relevant murine DVT model at femoral/saphenous vein induced by flow restriction and light illumination. • Our model newly succeeded in inducing DVT in a valve pocket and enabled
Autor:
David D. McPherson, Xing Yin, Christy K. Holland, Susan T. Laing, Mohammad H. Rahbar, Kevin J. Haworth, Patrick Kee, Curtis Genstler, Tao Peng, Shaoling Huang, Deborah Vela, Melanie R. Moody, Melvin E. Klegerman, Hyunggun Kim
Publikováno v:
JACC: Basic to Translational Science, Vol 5, Iss 1, Pp 1-11 (2020)
JACC: Basic to Translational Science
JACC: Basic to Translational Science
Visual Abstract
Highlights • Late in-stent restenosis is a significant problem in the management of atherosclerotic arterial disease that has not been completely ameliorated by the use of drug-eluting stents. • ELIPs have been developed by o
Highlights • Late in-stent restenosis is a significant problem in the management of atherosclerotic arterial disease that has not been completely ameliorated by the use of drug-eluting stents. • ELIPs have been developed by o
Autor:
Emiliano Votta, Carlo Antona, Michal Jaworek, Gianfranco Beniamino Fiore, Guido Gelpi, Omar Antonio Pappalardo, Claudia Romagnoni, Riccardo Vismara, Alberto Redaelli, Matteo Selmi, Nina Ajmone-Marsan, Federico Lucherini
Publikováno v:
Structural Heart. 4:36-45
Background: Functional tricuspid regurgitation (FTR) treatment is challenging and most therapies targeting tricuspid valve (TV) annulus have shown limited durability with high rate of resid...
Autor:
Randolph Ruiz Rodriguez, Fumiko Nakazeki, Takeshi Kimura, Chiharu Otani, Yuya Ide, Sijia Xu, Takahiro Horie, Akira Kakizuka, Toshimitsu Watanabe, Koh Ono, Yui Miyasaka, Satoshi Koyama, Yasuhide Kuwabara, Naritatsu Saito, Masamichi Yamamoto, Tomohiro Nishino, Shin Watanabe, Yasuhiro Nakashima, Tomohiro Yamasaki, Masahiro Kimura, Hitoo Nishi, Motoko Yanagita, Masataka Nishiga, Shuhei Tsuji, Tetsushi Nakao
Publikováno v:
JACC: Basic to Translational Science, Vol 4, Iss 6, Pp 701-714 (2019)
JACC: Basic to Translational Science
JACC: Basic to Translational Science
Visual Abstract
Highlights • KUS121 was developed to selectively inhibit the adenosine triphosphatase activity of valosin-containing protein without affecting other cellular functions of valosin-containing protein. • KUS121 preserved adenosi
Highlights • KUS121 was developed to selectively inhibit the adenosine triphosphatase activity of valosin-containing protein without affecting other cellular functions of valosin-containing protein. • KUS121 preserved adenosi
Publikováno v:
Current Diabetes Reviews. 15:349-356
Background:The sodium glucose co-transporter 2 (SGLT2) is primarily located within S1 of the renal proximal tubule being responsible for approximately 90% of glucose re-uptake in the kidney. Inhibition of SGLT2 is an exciting new pharmacological appr